Laundry detergents and surfactants‐induced eosinophilic airway inflammation by increasing IL‐33 expression and activating ILC2s

Introduction Epidemiological studies demonstrated that cleaning work and frequent use of cleaning products are risk factors for asthma. Laundry detergents have been reported to have epithelial barrier‐opening effects. However, whether laundry detergents directly induce airway inflammation and its me...

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Veröffentlicht in:	Allergy (Copenhagen) 2023-07, Vol.78 (7), p.1878-1892
Hauptverfasser:	Saito, Kyoko, Orimo, Keisuke, Kubo, Terufumi, Tamari, Masato, Yamada, Ayako, Motomura, Kenichiro, Sugiyama, Hiroki, Matsuoka, Ryo, Nagano, Naoko, Hayashi, Yuka, Arae, Ken, Hara, Mariko, Ikutani, Masashi, Fukuie, Tatsuki, Sudo, Katsuko, Matsuda, Akio, Ohya, Yukihiro, Fujieda, Shigeharu, Saito, Hirohisa, Nakae, Susumu, Matsumoto, Kenji, Akdis, Cezmi A., Morita, Hideaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Asthma bronchial asthma Cell activation Cosmetics Detergents Detergents - adverse effects Dust environment Epidemiology Epithelial cells Flow cytometry group 2 innate lymphoid cells (ILC2) House dust Humans hygiene hypothesis Immunity, Innate Inflammation Interleukin-33 - pharmacology Laundry Leukocytes (eosinophilic) Lymphocytes Lymphoid cells Mice Oxidative stress RAG2 protein Respiratory tract Respiratory tract diseases Risk factors Sodium lauryl sulfate Surface-Active Agents - adverse effects Surfactants Western blotting
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