Influence of variants in serotonin modulating genes on the risk, aggressiveness, and prognosis of oropharynx cancer

Background Serotonin (5‐HT) is involved in regulating tumor growth, as well as psychiatric disorders. It is synthesized by tryptophan hydroxylase (TPH) and acts through 5‐HT receptors (HTRs). Single‐nucleotide variations (SNVs) in TPH1 rs623580 (T>A), TPH2 rs4570625 (G>T), and HTR1D rs674386 (...

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Veröffentlicht in:	Head & neck 2023-07, Vol.45 (7), p.1790-1800
Hauptverfasser:	Queiroz, Gabriela Souza Rodrigues, Carron, Juliana, Macedo, Ligia Traldi, Lima, Carmen Silvia Passos, Lourenço, Gustavo Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	aggressiveness Mental disorders Oropharyngolaryngeal carcinoma Oropharynx oropharynx cancer prognosis risk Serotonin single‐nucleotide variant Statistical analysis Survival Throat cancer Tryptophan Tryptophan hydroxylase
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