Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?
Background In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5 years, 1 year, 3 months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12 year...
Gespeichert in:
| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2023-06, Vol.63 (6), p.1195-1203 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1203 |
|---|---|
| container_issue | 6 |
| container_start_page | 1195 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 63 |
| creator | O'Brien, Sheila F. Drews, Steven J. Yi, Qi‐Long Osmond, Lori Tran, Vanessa Zhou, Hong Yuan Goldman, Mindy |
| description | Background
In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5 years, 1 year, 3 months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12 years.
Study Design and Methods
Syphilis positivity in 10,288,322 whole blood donations (January 1, 2010–September 10, 2022) and gbMSM deferral time periods, donation status, age, and sex were analyzed with logistic regression. Overall, 26.9% syphilis positive and 42.2% controls (matched 1:4) participated in risk factor interviews analyzed by logistic regression.
Results
Syphilis rates were higher in first‐time donors (OR 27.0, 95% CI 22.1–33.0), in males (OR 2.3, 1.9–2.8) and with the 3‐month deferral (OR 3.4, 2.6–4.3) during which the increase was greater for first‐time males (p .05). Among first‐time donors, histories of intravenous drug use (OR 11.7, 2.0–69.5), male‐to‐male sex 7.8 (2.0–30.2) and birth in a high prevalence country (OR 7.6, 4.4–13.0) predicted syphilis positivity; among repeat donors, history of male‐to‐male sex (OR 33.5, CI 3.5–317.0). All but 1 gbMSM syphilis‐positive donors were noncompliant with the gbMSM deferral. About a quarter of first‐time interviewed case donors had history of syphilis; 44% were born in a high‐prevalence country.
Conclusion
Rising syphilis rates in donors correlates with the general population epidemic. Recent infection rates rose similarly in males and females. GbMSM history may contribute to donor syphilis rates but shortening time deferrals appears unrelated. |
| doi_str_mv | 10.1111/trf.17393 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2811570403</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2824577703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3883-3b7dba950942387f8eae2d5dd312f06c1070a19a9112f4e5b26cb542eb3d8c243</originalsourceid><addsrcrecordid>eNp10ctu1DAUBmALUdGhsOAFkCU2sEjrS1wnbCpUtVCpFRIq68hJTmbceuLhHAeU1-gT4zalC6R644s-_Tryz9g7KQ5lXkcJh0Npda1fsJU02haqrs1LthKilIWUWu2z10Q3QghVC_mK7WsrTaW0WbG7qzj6FNGPa07zbuODJ06AMcT1zP3I2xBjz_s4RqTP_IJ42gACn1KWaeaOuOM0Ica1S8C3Dm8BeRw4OAwzT-hGGibycVzOW0_k2wA5eoAu3b-3sHG_fUQXOHq6PXnD9gYXCN4-7gfs5_nZ9em34vL714vTL5dFp6tKF7q1fetqI-pS6coOFThQvel7LdUgjjsprHCydrXM9xJMq4671pQKWt1XnSr1Afu45O4w_pqAUpOH6yAEN0KcqFGVlMaKUuhMP_xHb-KEY54uK1Uaa-2D-rSoDiMRwtDs0OcfmRspmvuimlxU81BUtu8fE6d2C_2T_NdMBkcL-OMDzM8nNdc_zpfIv58Gn5Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2824577703</pqid></control><display><type>article</type><title>Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>O'Brien, Sheila F. ; Drews, Steven J. ; Yi, Qi‐Long ; Osmond, Lori ; Tran, Vanessa ; Zhou, Hong Yuan ; Goldman, Mindy</creator><creatorcontrib>O'Brien, Sheila F. ; Drews, Steven J. ; Yi, Qi‐Long ; Osmond, Lori ; Tran, Vanessa ; Zhou, Hong Yuan ; Goldman, Mindy</creatorcontrib><description>Background
In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5 years, 1 year, 3 months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12 years.
Study Design and Methods
Syphilis positivity in 10,288,322 whole blood donations (January 1, 2010–September 10, 2022) and gbMSM deferral time periods, donation status, age, and sex were analyzed with logistic regression. Overall, 26.9% syphilis positive and 42.2% controls (matched 1:4) participated in risk factor interviews analyzed by logistic regression.
Results
Syphilis rates were higher in first‐time donors (OR 27.0, 95% CI 22.1–33.0), in males (OR 2.3, 1.9–2.8) and with the 3‐month deferral (OR 3.4, 2.6–4.3) during which the increase was greater for first‐time males (p < .001) but similar for male and female repeat donors (p > .05). Among first‐time donors, histories of intravenous drug use (OR 11.7, 2.0–69.5), male‐to‐male sex 7.8 (2.0–30.2) and birth in a high prevalence country (OR 7.6, 4.4–13.0) predicted syphilis positivity; among repeat donors, history of male‐to‐male sex (OR 33.5, CI 3.5–317.0). All but 1 gbMSM syphilis‐positive donors were noncompliant with the gbMSM deferral. About a quarter of first‐time interviewed case donors had history of syphilis; 44% were born in a high‐prevalence country.
Conclusion
Rising syphilis rates in donors correlates with the general population epidemic. Recent infection rates rose similarly in males and females. GbMSM history may contribute to donor syphilis rates but shortening time deferrals appears unrelated.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/trf.17393</identifier><identifier>PMID: 37158235</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Bacterial infections ; Biomarkers ; Bisexuality ; Blood ; Blood & organ donations ; Blood Donors ; Canada ; Epidemics ; Female ; Females ; gbMSM ; Health risks ; HIV Infections ; Homosexuality, Male ; Humans ; Male ; Males ; Men ; Regression analysis ; Risk analysis ; Risk factors ; Risk taking ; Serology ; Sex ; Sexual and Gender Minorities ; Sexually transmitted diseases ; STD ; Syphilis ; Syphilis - epidemiology ; Treponema pallidum</subject><ispartof>Transfusion (Philadelphia, Pa.), 2023-06, Vol.63 (6), p.1195-1203</ispartof><rights>2023 The Authors. published by Wiley Periodicals LLC on behalf of AABB.</rights><rights>2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3883-3b7dba950942387f8eae2d5dd312f06c1070a19a9112f4e5b26cb542eb3d8c243</citedby><cites>FETCH-LOGICAL-c3883-3b7dba950942387f8eae2d5dd312f06c1070a19a9112f4e5b26cb542eb3d8c243</cites><orcidid>0000-0003-2519-1109 ; 0000-0002-5332-2789 ; 0000-0001-9904-9952</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftrf.17393$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftrf.17393$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37158235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Brien, Sheila F.</creatorcontrib><creatorcontrib>Drews, Steven J.</creatorcontrib><creatorcontrib>Yi, Qi‐Long</creatorcontrib><creatorcontrib>Osmond, Lori</creatorcontrib><creatorcontrib>Tran, Vanessa</creatorcontrib><creatorcontrib>Zhou, Hong Yuan</creatorcontrib><creatorcontrib>Goldman, Mindy</creatorcontrib><title>Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>Background
In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5 years, 1 year, 3 months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12 years.
Study Design and Methods
Syphilis positivity in 10,288,322 whole blood donations (January 1, 2010–September 10, 2022) and gbMSM deferral time periods, donation status, age, and sex were analyzed with logistic regression. Overall, 26.9% syphilis positive and 42.2% controls (matched 1:4) participated in risk factor interviews analyzed by logistic regression.
Results
Syphilis rates were higher in first‐time donors (OR 27.0, 95% CI 22.1–33.0), in males (OR 2.3, 1.9–2.8) and with the 3‐month deferral (OR 3.4, 2.6–4.3) during which the increase was greater for first‐time males (p < .001) but similar for male and female repeat donors (p > .05). Among first‐time donors, histories of intravenous drug use (OR 11.7, 2.0–69.5), male‐to‐male sex 7.8 (2.0–30.2) and birth in a high prevalence country (OR 7.6, 4.4–13.0) predicted syphilis positivity; among repeat donors, history of male‐to‐male sex (OR 33.5, CI 3.5–317.0). All but 1 gbMSM syphilis‐positive donors were noncompliant with the gbMSM deferral. About a quarter of first‐time interviewed case donors had history of syphilis; 44% were born in a high‐prevalence country.
Conclusion
Rising syphilis rates in donors correlates with the general population epidemic. Recent infection rates rose similarly in males and females. GbMSM history may contribute to donor syphilis rates but shortening time deferrals appears unrelated.</description><subject>Bacterial infections</subject><subject>Biomarkers</subject><subject>Bisexuality</subject><subject>Blood</subject><subject>Blood & organ donations</subject><subject>Blood Donors</subject><subject>Canada</subject><subject>Epidemics</subject><subject>Female</subject><subject>Females</subject><subject>gbMSM</subject><subject>Health risks</subject><subject>HIV Infections</subject><subject>Homosexuality, Male</subject><subject>Humans</subject><subject>Male</subject><subject>Males</subject><subject>Men</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Risk taking</subject><subject>Serology</subject><subject>Sex</subject><subject>Sexual and Gender Minorities</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Syphilis</subject><subject>Syphilis - epidemiology</subject><subject>Treponema pallidum</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALUdGhsOAFkCU2sEjrS1wnbCpUtVCpFRIq68hJTmbceuLhHAeU1-gT4zalC6R644s-_Tryz9g7KQ5lXkcJh0Npda1fsJU02haqrs1LthKilIWUWu2z10Q3QghVC_mK7WsrTaW0WbG7qzj6FNGPa07zbuODJ06AMcT1zP3I2xBjz_s4RqTP_IJ42gACn1KWaeaOuOM0Ica1S8C3Dm8BeRw4OAwzT-hGGibycVzOW0_k2wA5eoAu3b-3sHG_fUQXOHq6PXnD9gYXCN4-7gfs5_nZ9em34vL714vTL5dFp6tKF7q1fetqI-pS6coOFThQvel7LdUgjjsprHCydrXM9xJMq4671pQKWt1XnSr1Afu45O4w_pqAUpOH6yAEN0KcqFGVlMaKUuhMP_xHb-KEY54uK1Uaa-2D-rSoDiMRwtDs0OcfmRspmvuimlxU81BUtu8fE6d2C_2T_NdMBkcL-OMDzM8nNdc_zpfIv58Gn5Y</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>O'Brien, Sheila F.</creator><creator>Drews, Steven J.</creator><creator>Yi, Qi‐Long</creator><creator>Osmond, Lori</creator><creator>Tran, Vanessa</creator><creator>Zhou, Hong Yuan</creator><creator>Goldman, Mindy</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2519-1109</orcidid><orcidid>https://orcid.org/0000-0002-5332-2789</orcidid><orcidid>https://orcid.org/0000-0001-9904-9952</orcidid></search><sort><creationdate>202306</creationdate><title>Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?</title><author>O'Brien, Sheila F. ; Drews, Steven J. ; Yi, Qi‐Long ; Osmond, Lori ; Tran, Vanessa ; Zhou, Hong Yuan ; Goldman, Mindy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3883-3b7dba950942387f8eae2d5dd312f06c1070a19a9112f4e5b26cb542eb3d8c243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bacterial infections</topic><topic>Biomarkers</topic><topic>Bisexuality</topic><topic>Blood</topic><topic>Blood & organ donations</topic><topic>Blood Donors</topic><topic>Canada</topic><topic>Epidemics</topic><topic>Female</topic><topic>Females</topic><topic>gbMSM</topic><topic>Health risks</topic><topic>HIV Infections</topic><topic>Homosexuality, Male</topic><topic>Humans</topic><topic>Male</topic><topic>Males</topic><topic>Men</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Risk taking</topic><topic>Serology</topic><topic>Sex</topic><topic>Sexual and Gender Minorities</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Syphilis</topic><topic>Syphilis - epidemiology</topic><topic>Treponema pallidum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Brien, Sheila F.</creatorcontrib><creatorcontrib>Drews, Steven J.</creatorcontrib><creatorcontrib>Yi, Qi‐Long</creatorcontrib><creatorcontrib>Osmond, Lori</creatorcontrib><creatorcontrib>Tran, Vanessa</creatorcontrib><creatorcontrib>Zhou, Hong Yuan</creatorcontrib><creatorcontrib>Goldman, Mindy</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Brien, Sheila F.</au><au>Drews, Steven J.</au><au>Yi, Qi‐Long</au><au>Osmond, Lori</au><au>Tran, Vanessa</au><au>Zhou, Hong Yuan</au><au>Goldman, Mindy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk?</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2023-06</date><risdate>2023</risdate><volume>63</volume><issue>6</issue><spage>1195</spage><epage>1203</epage><pages>1195-1203</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>Background
In Canada the time deferral for gay, bisexual, and other men who have sex with men (gbMSM) was progressively shortened (lifetime, 5 years, 1 year, 3 months). Here we describe trends in syphilis rates (a potential sexual risk marker) and risk behaviors from blood donors in the past 12 years.
Study Design and Methods
Syphilis positivity in 10,288,322 whole blood donations (January 1, 2010–September 10, 2022) and gbMSM deferral time periods, donation status, age, and sex were analyzed with logistic regression. Overall, 26.9% syphilis positive and 42.2% controls (matched 1:4) participated in risk factor interviews analyzed by logistic regression.
Results
Syphilis rates were higher in first‐time donors (OR 27.0, 95% CI 22.1–33.0), in males (OR 2.3, 1.9–2.8) and with the 3‐month deferral (OR 3.4, 2.6–4.3) during which the increase was greater for first‐time males (p < .001) but similar for male and female repeat donors (p > .05). Among first‐time donors, histories of intravenous drug use (OR 11.7, 2.0–69.5), male‐to‐male sex 7.8 (2.0–30.2) and birth in a high prevalence country (OR 7.6, 4.4–13.0) predicted syphilis positivity; among repeat donors, history of male‐to‐male sex (OR 33.5, CI 3.5–317.0). All but 1 gbMSM syphilis‐positive donors were noncompliant with the gbMSM deferral. About a quarter of first‐time interviewed case donors had history of syphilis; 44% were born in a high‐prevalence country.
Conclusion
Rising syphilis rates in donors correlates with the general population epidemic. Recent infection rates rose similarly in males and females. GbMSM history may contribute to donor syphilis rates but shortening time deferrals appears unrelated.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>37158235</pmid><doi>10.1111/trf.17393</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2519-1109</orcidid><orcidid>https://orcid.org/0000-0002-5332-2789</orcidid><orcidid>https://orcid.org/0000-0001-9904-9952</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1132 |
| ispartof | Transfusion (Philadelphia, Pa.), 2023-06, Vol.63 (6), p.1195-1203 |
| issn | 0041-1132 1537-2995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2811570403 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Bacterial infections Biomarkers Bisexuality Blood Blood & organ donations Blood Donors Canada Epidemics Female Females gbMSM Health risks HIV Infections Homosexuality, Male Humans Male Males Men Regression analysis Risk analysis Risk factors Risk taking Serology Sex Sexual and Gender Minorities Sexually transmitted diseases STD Syphilis Syphilis - epidemiology Treponema pallidum |
| title | Monitoring syphilis serology in blood donors: Is there utility as a surrogate marker of early transfusion transmissible infection behavioral risk? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T11%3A35%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Monitoring%20syphilis%20serology%20in%20blood%20donors:%20Is%20there%20utility%20as%20a%20surrogate%20marker%20of%20early%20transfusion%20transmissible%20infection%20behavioral%20risk?&rft.jtitle=Transfusion%20(Philadelphia,%20Pa.)&rft.au=O'Brien,%20Sheila%20F.&rft.date=2023-06&rft.volume=63&rft.issue=6&rft.spage=1195&rft.epage=1203&rft.pages=1195-1203&rft.issn=0041-1132&rft.eissn=1537-2995&rft_id=info:doi/10.1111/trf.17393&rft_dat=%3Cproquest_cross%3E2824577703%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2824577703&rft_id=info:pmid/37158235&rfr_iscdi=true |