PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation

Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusio...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2023-08, Vol.82 (2), p.128-137
Hauptverfasser:	Fu, Caihua, Yu, Shengbo, Liu, Zhiquan, Wang, Jiayu, Liu, Ping, Su, Guohai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Monophosphate - pharmacology AMP-Activated Protein Kinases - metabolism Animals Apoptosis Ferroptosis Glucose - metabolism Mice Myocardial Reperfusion Injury - metabolism Reperfusion Injury - metabolism Signal Transduction
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