PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation
Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusio...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 2023-08, Vol.82 (2), p.128-137 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Fu, Caihua Yu, Shengbo Liu, Zhiquan Wang, Jiayu Liu, Ping Su, Guohai |
| description | Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R) models were established. PFKFB2 expression was enhanced in I/R mice and OGD/R H9c2 cells. Overexpression of PFKFB2 improves heart function in I/R mice. Overexpression of PFKFB2 inhibits I/R and OGD/R-induced ferroptosis in mice and H9c2 cells. Mechanistically, overexpression of PFKFB2 activates the adenosine monophosphate-activated protein kinase (AMPK). AMPK inhibitor compound C reverses effect of PFKFB2 overexpression in reducing ferroptosis under OGD/R treatment. In conclusion, PFKFB2 protects hearts against I/R-induced ferroptosis through activation of the AMPK signaling pathway. |
| doi_str_mv | 10.1097/FJC.0000000000001437 |
| format | Article |
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This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R) models were established. PFKFB2 expression was enhanced in I/R mice and OGD/R H9c2 cells. Overexpression of PFKFB2 improves heart function in I/R mice. Overexpression of PFKFB2 inhibits I/R and OGD/R-induced ferroptosis in mice and H9c2 cells. Mechanistically, overexpression of PFKFB2 activates the adenosine monophosphate-activated protein kinase (AMPK). AMPK inhibitor compound C reverses effect of PFKFB2 overexpression in reducing ferroptosis under OGD/R treatment. In conclusion, PFKFB2 protects hearts against I/R-induced ferroptosis through activation of the AMPK signaling pathway.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/FJC.0000000000001437</identifier><identifier>PMID: 37155368</identifier><language>eng</language><publisher>United States</publisher><subject>Adenosine Monophosphate - pharmacology ; AMP-Activated Protein Kinases - metabolism ; Animals ; Apoptosis ; Ferroptosis ; Glucose - metabolism ; Mice ; Myocardial Reperfusion Injury - metabolism ; Reperfusion Injury - metabolism ; Signal Transduction</subject><ispartof>Journal of cardiovascular pharmacology, 2023-08, Vol.82 (2), p.128-137</ispartof><rights>Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-ca8403ec6e90a4c98495dffd814aa1c6b8944d7a9e21b765d58a72bce7c2bce83</citedby><cites>FETCH-LOGICAL-c307t-ca8403ec6e90a4c98495dffd814aa1c6b8944d7a9e21b765d58a72bce7c2bce83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37155368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Caihua</creatorcontrib><creatorcontrib>Yu, Shengbo</creatorcontrib><creatorcontrib>Liu, Zhiquan</creatorcontrib><creatorcontrib>Wang, Jiayu</creatorcontrib><creatorcontrib>Liu, Ping</creatorcontrib><creatorcontrib>Su, Guohai</creatorcontrib><title>PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R) models were established. PFKFB2 expression was enhanced in I/R mice and OGD/R H9c2 cells. Overexpression of PFKFB2 improves heart function in I/R mice. Overexpression of PFKFB2 inhibits I/R and OGD/R-induced ferroptosis in mice and H9c2 cells. Mechanistically, overexpression of PFKFB2 activates the adenosine monophosphate-activated protein kinase (AMPK). AMPK inhibitor compound C reverses effect of PFKFB2 overexpression in reducing ferroptosis under OGD/R treatment. In conclusion, PFKFB2 protects hearts against I/R-induced ferroptosis through activation of the AMPK signaling pathway.</description><subject>Adenosine Monophosphate - pharmacology</subject><subject>AMP-Activated Protein Kinases - metabolism</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Ferroptosis</subject><subject>Glucose - metabolism</subject><subject>Mice</subject><subject>Myocardial Reperfusion Injury - metabolism</subject><subject>Reperfusion Injury - metabolism</subject><subject>Signal Transduction</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9KwzAUxoMoOv-8gUguvelMmjRpLuewOnU4ZF6XND21ka2pSSvsEXxrO5winotzAuf7fQfyIXROyZgSJa-y--mY_CnKmdxDI5owFnESs300IlSQKOZcHKHjEN62mkSKQ3TEJE0SJtIR-lxkD9l1jGdNbQvbBZyB967tXLAB2wbPN85oX1q9wrNgalhbffUMLfiqD9Y1A_fW-w1e1t71rzWelNAMaAN47hrX1i60te4gmpjOfgyPEi-862AwfrCNDoB3i8HqFB1UehXgbDdP0Et2s5zeRY9Pt7Pp5DEyjMguMjrlhIERoIjmRqVcJWVVlSnlWlMjilRxXkqtIKaFFEmZpFrGhQFptj1lJ-jy27f17r2H0OVrGwysVroB14c8TilNhFIiHqT8W2q8C8FDlbferrXf5JTk2xDyIYT8fwgDdrG70BdrKH-hn19nX1gxhQk</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Fu, Caihua</creator><creator>Yu, Shengbo</creator><creator>Liu, Zhiquan</creator><creator>Wang, Jiayu</creator><creator>Liu, Ping</creator><creator>Su, Guohai</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230801</creationdate><title>PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation</title><author>Fu, Caihua ; Yu, Shengbo ; Liu, Zhiquan ; Wang, Jiayu ; Liu, Ping ; Su, Guohai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-ca8403ec6e90a4c98495dffd814aa1c6b8944d7a9e21b765d58a72bce7c2bce83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenosine Monophosphate - pharmacology</topic><topic>AMP-Activated Protein Kinases - metabolism</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Ferroptosis</topic><topic>Glucose - metabolism</topic><topic>Mice</topic><topic>Myocardial Reperfusion Injury - metabolism</topic><topic>Reperfusion Injury - metabolism</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Caihua</creatorcontrib><creatorcontrib>Yu, Shengbo</creatorcontrib><creatorcontrib>Liu, Zhiquan</creatorcontrib><creatorcontrib>Wang, Jiayu</creatorcontrib><creatorcontrib>Liu, Ping</creatorcontrib><creatorcontrib>Su, Guohai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Caihua</au><au>Yu, Shengbo</au><au>Liu, Zhiquan</au><au>Wang, Jiayu</au><au>Liu, Ping</au><au>Su, Guohai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>82</volume><issue>2</issue><spage>128</spage><epage>137</epage><pages>128-137</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>Six-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 (PFKFB2) is a key regulator of glycolytic enzyme. This study identified whether PFKFB2 can regulate myocardial ferroptosis in ischemia/reperfusion (I/R) injury. Mice myocardial (I/R) injury and H9c2 cells oxygen-glucose deprivation/reperfusion (OGD/R) models were established. PFKFB2 expression was enhanced in I/R mice and OGD/R H9c2 cells. Overexpression of PFKFB2 improves heart function in I/R mice. Overexpression of PFKFB2 inhibits I/R and OGD/R-induced ferroptosis in mice and H9c2 cells. Mechanistically, overexpression of PFKFB2 activates the adenosine monophosphate-activated protein kinase (AMPK). AMPK inhibitor compound C reverses effect of PFKFB2 overexpression in reducing ferroptosis under OGD/R treatment. In conclusion, PFKFB2 protects hearts against I/R-induced ferroptosis through activation of the AMPK signaling pathway.</abstract><cop>United States</cop><pmid>37155368</pmid><doi>10.1097/FJC.0000000000001437</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adenosine Monophosphate - pharmacology AMP-Activated Protein Kinases - metabolism Animals Apoptosis Ferroptosis Glucose - metabolism Mice Myocardial Reperfusion Injury - metabolism Reperfusion Injury - metabolism Signal Transduction |
| title | PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation |
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