Longitudinal stability of progression‐related microglial activity during teriflunomide treatment in patients with multiple sclerosis

Background and purpose The aim was to study brain innate immune cell activation in teriflunomide‐treated patients with relapsing–remitting multiple sclerosis. Methods Imaging with 18‐kDa translocator protein positron emission tomography (TSPO‐PET) using the [11C]PK11195 radioligand was employed to a...

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Veröffentlicht in:	European journal of neurology 2023-08, Vol.30 (8), p.2365-2375
Hauptverfasser:	Lehto, Jussi, Nylund, Marjo, Matilainen, Markus, Sucksdorff, Marcus, Vuorimaa, Anna, Rajander, Johan, Wahlroos, Saara, Hariri, Parisa, Airas, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Brain - pathology Brain mapping Cell activation Evaluation Humans Immune system Inflammation Inflammation - pathology Iron Iron - metabolism Lesions Longitudinal stability Magnetic Resonance Imaging Medical imaging Microglia - metabolism Microglia - pathology Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - drug therapy Multiple Sclerosis - metabolism Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging Multiple Sclerosis, Relapsing-Remitting - drug therapy Neuroimaging Positron emission Positron emission tomography quantitative susceptibility mapping Receptors, GABA - metabolism Smoldering Substantia alba teriflunomide Thalamus Tomography White Matter - pathology
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