Microfluidic Biosensor Integrated with Signal Transduction and Enhancement Mechanism for Ultrasensitive Noncompetitive Assay of Multiple Mycotoxins

To achieve high-throughput ultrasensitive detection of mycotoxins in food, a functional DNA-guided transition-state CRISPR/Cas12a microfluidic biosensor (named FTMB) was successfully constructed. The signal transduction CRISPR/Cas12a strategy in FTMB has utilized DNA sequences with a specific recogn...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-05, Vol.95 (20), p.7993-8001
Hauptverfasser:	Xiang, Xinran, Song, Minghui, Xu, Xiaowei, Lu, Jiaran, Chen, Yuanyuan, Chen, Shuhan, He, Yinglong, Shang, Yuting
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Biological Assay Biosensing Techniques Biosensors Chemistry Chromatography, High Pressure Liquid Coefficient of variation CRISPR CRISPR-Cas Systems Crystals Deoxyribonucleic acid DNA Food safety Gene sequencing Liquid chromatography Low concentrations Mathematical analysis Microfluidics Mycotoxins Nucleotide sequence Photonic band gaps Photonic crystals Quantum dots Signal Transduction Switches
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