Inhalable mixture of polycyclic aromatic hydrocarbons and metals, DNA oxidative stress and nasal ribosomal DNA copy number amplification: Direct and indirect effect analyses among population
The ribosomal DNA (rDNA) plays a crucial role in maintaining genome stability. So far, alterations of rDNA from airborne pollutants exposure remain unclear. Nasal epithelial cells are the earliest respiratory barrier, which has an accessible surrogate for evaluating respiratory impairment. We develo...
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| Veröffentlicht in: | Journal of hazardous materials 2023-08, Vol.455, p.131538-131538, Article 131538 |
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| creator | Wang, Yanhua Meng, Tao Zhang, Liya Lin, Yang Wu, Nan Yuan, Huige He, Zhizhou Niu, Yong Dai, Yufei Zhao, Xing Duan, Huawei |
| description | The ribosomal DNA (rDNA) plays a crucial role in maintaining genome stability. So far, alterations of rDNA from airborne pollutants exposure remain unclear. Nasal epithelial cells are the earliest respiratory barrier, which has an accessible surrogate for evaluating respiratory impairment. We developed a mixture-centered biomarkers study integrated epidemiological and biological evidence among 768 subjects, a mixture of polycyclic aromatic hydrocarbons (PAHs) and metals. We identified the mixed exposure of PAHs and metals by environmental and biological monitoring, selected urinary 8-hydroxy-2′-deoxyguanosine as DNA oxidative stress marker, and measured their rDNA copy number (rDNA CN) in nasal epithelial cells. We performed linear regression, adaptive elastic net regression, BKMR, and mediation analyses to assess the direct and indirect effects. We found a 10% elevation in urinary 1-hydroxypyrene was correlated with a separate 0.31% and 0.82% amplification of nasal 5S and 45S rDNA CN, respectively (all P |
| doi_str_mv | 10.1016/j.jhazmat.2023.131538 |
| format | Article |
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[Display omitted]
•The nasal rDNA CN amplification presented in PAHs and metals exposed population.•PAHs and Ni in the mixture played a substantial role in expanding nasal rDNA.•DNA oxidative stress might trigger rDNA instability induced by inhaled PAHs and Ni.•Nasal rDNA alteration may serve as the predictive biomarker of respiratory impairment.</description><identifier>ISSN: 0304-3894</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2023.131538</identifier><identifier>PMID: 37156045</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>8-Hydroxy-2'-Deoxyguanosine ; Biomarkers ; DNA Copy Number Variations ; DNA, Ribosomal ; Humans ; Metals ; Metals - toxicity ; Nasal epithelial cell ; Nickel ; Oxidative Stress ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - analysis ; Polycyclic Aromatic Hydrocarbons - toxicity ; Ribosomal DNA instability</subject><ispartof>Journal of hazardous materials, 2023-08, Vol.455, p.131538-131538, Article 131538</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-3e658d995db93747a75a8a5adbccd36f8490d608a8a9ecd06e8d9aefb07271103</citedby><cites>FETCH-LOGICAL-c365t-3e658d995db93747a75a8a5adbccd36f8490d608a8a9ecd06e8d9aefb07271103</cites><orcidid>0000-0002-2717-7936 ; 0009-0008-9527-2936</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhazmat.2023.131538$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37156045$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Yanhua</creatorcontrib><creatorcontrib>Meng, Tao</creatorcontrib><creatorcontrib>Zhang, Liya</creatorcontrib><creatorcontrib>Lin, Yang</creatorcontrib><creatorcontrib>Wu, Nan</creatorcontrib><creatorcontrib>Yuan, Huige</creatorcontrib><creatorcontrib>He, Zhizhou</creatorcontrib><creatorcontrib>Niu, Yong</creatorcontrib><creatorcontrib>Dai, Yufei</creatorcontrib><creatorcontrib>Zhao, Xing</creatorcontrib><creatorcontrib>Duan, Huawei</creatorcontrib><title>Inhalable mixture of polycyclic aromatic hydrocarbons and metals, DNA oxidative stress and nasal ribosomal DNA copy number amplification: Direct and indirect effect analyses among population</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>The ribosomal DNA (rDNA) plays a crucial role in maintaining genome stability. So far, alterations of rDNA from airborne pollutants exposure remain unclear. Nasal epithelial cells are the earliest respiratory barrier, which has an accessible surrogate for evaluating respiratory impairment. We developed a mixture-centered biomarkers study integrated epidemiological and biological evidence among 768 subjects, a mixture of polycyclic aromatic hydrocarbons (PAHs) and metals. We identified the mixed exposure of PAHs and metals by environmental and biological monitoring, selected urinary 8-hydroxy-2′-deoxyguanosine as DNA oxidative stress marker, and measured their rDNA copy number (rDNA CN) in nasal epithelial cells. We performed linear regression, adaptive elastic net regression, BKMR, and mediation analyses to assess the direct and indirect effects. We found a 10% elevation in urinary 1-hydroxypyrene was correlated with a separate 0.31% and 0.82% amplification of nasal 5S and 45S rDNA CN, respectively (all P < 0.05). A 10% increment of urine nickel was associated with a separate 0.37% and 1.18% elevation of nasal 5S and 45S rDNA CN, respectively (all P < 0.05). BKMR results also confirmed our findings of PAHs and nickel. Our findings suggested that DNA oxidative stress might trigger rDNA instability induced by inhaled PAHs and metals.
[Display omitted]
•The nasal rDNA CN amplification presented in PAHs and metals exposed population.•PAHs and Ni in the mixture played a substantial role in expanding nasal rDNA.•DNA oxidative stress might trigger rDNA instability induced by inhaled PAHs and Ni.•Nasal rDNA alteration may serve as the predictive biomarker of respiratory impairment.</description><subject>8-Hydroxy-2'-Deoxyguanosine</subject><subject>Biomarkers</subject><subject>DNA Copy Number Variations</subject><subject>DNA, Ribosomal</subject><subject>Humans</subject><subject>Metals</subject><subject>Metals - toxicity</subject><subject>Nasal epithelial cell</subject><subject>Nickel</subject><subject>Oxidative Stress</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - analysis</subject><subject>Polycyclic Aromatic Hydrocarbons - toxicity</subject><subject>Ribosomal DNA instability</subject><issn>0304-3894</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EokvhEUA-ciCLvY7zhwuqWmgrVXCBszWxJ6xXjh3spGp4OJ4Nd7Nw5WR79PvmG89HyGvOtpzx6v1he9jDrwGm7Y7txJYLLkXzhGx4U4tCCFE9JRsmWFmIpi3PyIuUDowxXsvyOTkTNZcVK-WG_L71e3DQOaSDfZjmiDT0dAxu0Yt2VlOIIZvky34xMWiIXfCJgjd0wAlcekevvlzQ8GBNpu6RpiliWgEPCRyNtgsp93BHUIdxoX4eOowUhtHZ3uosDP4DvbIR9XRUWm_WB_b9WgO3JMxth-B_5PHG2R1VL8mzPg-Br07nOfn--dO3y5vi7uv17eXFXaFFJadCYCUb07bSdK2oyxpqCQ1IMJ3WRlR9U7bMVKzJxRa1YRVmGrDvWL2rOWfinLxd-44x_JwxTWqwSaNz4DHMSe0anjda1YJnVK6ojiGliL0aox0gLooz9RidOqhTdOoxOrVGl3VvThZzN6D5p_qbVQY-rgDmj95bjCppi17juitlgv2PxR89z7IS</recordid><startdate>20230805</startdate><enddate>20230805</enddate><creator>Wang, Yanhua</creator><creator>Meng, Tao</creator><creator>Zhang, Liya</creator><creator>Lin, Yang</creator><creator>Wu, Nan</creator><creator>Yuan, Huige</creator><creator>He, Zhizhou</creator><creator>Niu, Yong</creator><creator>Dai, Yufei</creator><creator>Zhao, Xing</creator><creator>Duan, Huawei</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2717-7936</orcidid><orcidid>https://orcid.org/0009-0008-9527-2936</orcidid></search><sort><creationdate>20230805</creationdate><title>Inhalable mixture of polycyclic aromatic hydrocarbons and metals, DNA oxidative stress and nasal ribosomal DNA copy number amplification: Direct and indirect effect analyses among population</title><author>Wang, Yanhua ; Meng, Tao ; Zhang, Liya ; Lin, Yang ; Wu, Nan ; Yuan, Huige ; He, Zhizhou ; Niu, Yong ; Dai, Yufei ; Zhao, Xing ; Duan, Huawei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-3e658d995db93747a75a8a5adbccd36f8490d608a8a9ecd06e8d9aefb07271103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>8-Hydroxy-2'-Deoxyguanosine</topic><topic>Biomarkers</topic><topic>DNA Copy Number Variations</topic><topic>DNA, Ribosomal</topic><topic>Humans</topic><topic>Metals</topic><topic>Metals - toxicity</topic><topic>Nasal epithelial cell</topic><topic>Nickel</topic><topic>Oxidative Stress</topic><topic>Polycyclic aromatic hydrocarbons</topic><topic>Polycyclic Aromatic Hydrocarbons - analysis</topic><topic>Polycyclic Aromatic Hydrocarbons - toxicity</topic><topic>Ribosomal DNA instability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Yanhua</creatorcontrib><creatorcontrib>Meng, Tao</creatorcontrib><creatorcontrib>Zhang, Liya</creatorcontrib><creatorcontrib>Lin, Yang</creatorcontrib><creatorcontrib>Wu, Nan</creatorcontrib><creatorcontrib>Yuan, Huige</creatorcontrib><creatorcontrib>He, Zhizhou</creatorcontrib><creatorcontrib>Niu, Yong</creatorcontrib><creatorcontrib>Dai, Yufei</creatorcontrib><creatorcontrib>Zhao, Xing</creatorcontrib><creatorcontrib>Duan, Huawei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Yanhua</au><au>Meng, Tao</au><au>Zhang, Liya</au><au>Lin, Yang</au><au>Wu, Nan</au><au>Yuan, Huige</au><au>He, Zhizhou</au><au>Niu, Yong</au><au>Dai, Yufei</au><au>Zhao, Xing</au><au>Duan, Huawei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhalable mixture of polycyclic aromatic hydrocarbons and metals, DNA oxidative stress and nasal ribosomal DNA copy number amplification: Direct and indirect effect analyses among population</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2023-08-05</date><risdate>2023</risdate><volume>455</volume><spage>131538</spage><epage>131538</epage><pages>131538-131538</pages><artnum>131538</artnum><issn>0304-3894</issn><eissn>1873-3336</eissn><abstract>The ribosomal DNA (rDNA) plays a crucial role in maintaining genome stability. So far, alterations of rDNA from airborne pollutants exposure remain unclear. Nasal epithelial cells are the earliest respiratory barrier, which has an accessible surrogate for evaluating respiratory impairment. We developed a mixture-centered biomarkers study integrated epidemiological and biological evidence among 768 subjects, a mixture of polycyclic aromatic hydrocarbons (PAHs) and metals. We identified the mixed exposure of PAHs and metals by environmental and biological monitoring, selected urinary 8-hydroxy-2′-deoxyguanosine as DNA oxidative stress marker, and measured their rDNA copy number (rDNA CN) in nasal epithelial cells. We performed linear regression, adaptive elastic net regression, BKMR, and mediation analyses to assess the direct and indirect effects. We found a 10% elevation in urinary 1-hydroxypyrene was correlated with a separate 0.31% and 0.82% amplification of nasal 5S and 45S rDNA CN, respectively (all P < 0.05). A 10% increment of urine nickel was associated with a separate 0.37% and 1.18% elevation of nasal 5S and 45S rDNA CN, respectively (all P < 0.05). BKMR results also confirmed our findings of PAHs and nickel. Our findings suggested that DNA oxidative stress might trigger rDNA instability induced by inhaled PAHs and metals.
[Display omitted]
•The nasal rDNA CN amplification presented in PAHs and metals exposed population.•PAHs and Ni in the mixture played a substantial role in expanding nasal rDNA.•DNA oxidative stress might trigger rDNA instability induced by inhaled PAHs and Ni.•Nasal rDNA alteration may serve as the predictive biomarker of respiratory impairment.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37156045</pmid><doi>10.1016/j.jhazmat.2023.131538</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2717-7936</orcidid><orcidid>https://orcid.org/0009-0008-9527-2936</orcidid></addata></record> |
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| ispartof | Journal of hazardous materials, 2023-08, Vol.455, p.131538-131538, Article 131538 |
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| subjects | 8-Hydroxy-2'-Deoxyguanosine Biomarkers DNA Copy Number Variations DNA, Ribosomal Humans Metals Metals - toxicity Nasal epithelial cell Nickel Oxidative Stress Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - analysis Polycyclic Aromatic Hydrocarbons - toxicity Ribosomal DNA instability |
| title | Inhalable mixture of polycyclic aromatic hydrocarbons and metals, DNA oxidative stress and nasal ribosomal DNA copy number amplification: Direct and indirect effect analyses among population |
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