Major open abdominal surgery is associated with increased levels of endothelial damage and interleukin-6
To examine changes in biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress following major open abdominal surgery and the correlation to postoperative morbidity. Major abdominal surgery is associated with high levels of postoperative morbidity. Two possible reasons...
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| Veröffentlicht in: | Microvascular research 2023-07, Vol.148, p.104543-104543, Article 104543 |
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| creator | Gregersen, Jeppe Skovgaard Bazancir, Laser Arif Johansson, Pär Ingemar Sørensen, Henrik Achiam, Michael Patrick Olsen, August Adelsten |
| description | To examine changes in biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress following major open abdominal surgery and the correlation to postoperative morbidity.
Major abdominal surgery is associated with high levels of postoperative morbidity. Two possible reasons are the surgical stress response and the impairment of the glycocalyx and endothelial cells. Further, the degree of these responses may correlate with postoperative morbidity and complications.
A secondary data analysis of prospectively collected data from two cohorts of patients undergoing open liver surgery, gastrectomy, esophagectomy, or Whipple procedure (n = 112). Hemodynamics and blood samples were collected at predefined timestamps and analyzed for biomarkers of glycocalyx shedding (Syndecan-1), endothelial activation (sVEGFR1), endothelial damage (sThrombomodulin (sTM)), and surgical stress (IL6).
Major abdominal surgery led to increased levels of IL6 (0 to 85 pg/mL), Syndecan-1 (17.2 to 46.4 ng/mL), and sVEGFR1 (382.8 to 526.5 pg/mL), peaking at the end of the surgery. In contrast, sTM, did not increase during surgery, but increased significantly following surgery (5.9 to 6.9 ng/mL), peaking at 18 h following the end of surgery. Patients characterized with high postoperative morbidity had higher levels of IL6 (132 vs. 78 pg/mL, p = 0.007) and sVEGFR1 (563.1 vs. 509.4 pg/mL, p = 0.045) at the end of the surgery, and of sTM (8.2 vs. 6.4 ng/mL, p = 0.038) 18 h following surgery.
Major abdominal surgery leads to significantly increased levels of biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress, with the highest levels seen in patients developing high postoperative morbidity.
•Major abdominal surgery is associated with high levels of postoperative morbidity.•Corticosteroid did not affect the pathophysiology of high postoperative morbidity.•Increased sVEGFR1, sTM and IL6 are associated with high postoperative morbidity.•Major abdominal surgery leads to increased endothelial dysfunction. |
| doi_str_mv | 10.1016/j.mvr.2023.104543 |
| format | Article |
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Major abdominal surgery is associated with high levels of postoperative morbidity. Two possible reasons are the surgical stress response and the impairment of the glycocalyx and endothelial cells. Further, the degree of these responses may correlate with postoperative morbidity and complications.
A secondary data analysis of prospectively collected data from two cohorts of patients undergoing open liver surgery, gastrectomy, esophagectomy, or Whipple procedure (n = 112). Hemodynamics and blood samples were collected at predefined timestamps and analyzed for biomarkers of glycocalyx shedding (Syndecan-1), endothelial activation (sVEGFR1), endothelial damage (sThrombomodulin (sTM)), and surgical stress (IL6).
Major abdominal surgery led to increased levels of IL6 (0 to 85 pg/mL), Syndecan-1 (17.2 to 46.4 ng/mL), and sVEGFR1 (382.8 to 526.5 pg/mL), peaking at the end of the surgery. In contrast, sTM, did not increase during surgery, but increased significantly following surgery (5.9 to 6.9 ng/mL), peaking at 18 h following the end of surgery. Patients characterized with high postoperative morbidity had higher levels of IL6 (132 vs. 78 pg/mL, p = 0.007) and sVEGFR1 (563.1 vs. 509.4 pg/mL, p = 0.045) at the end of the surgery, and of sTM (8.2 vs. 6.4 ng/mL, p = 0.038) 18 h following surgery.
Major abdominal surgery leads to significantly increased levels of biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress, with the highest levels seen in patients developing high postoperative morbidity.
•Major abdominal surgery is associated with high levels of postoperative morbidity.•Corticosteroid did not affect the pathophysiology of high postoperative morbidity.•Increased sVEGFR1, sTM and IL6 are associated with high postoperative morbidity.•Major abdominal surgery leads to increased endothelial dysfunction.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2023.104543</identifier><identifier>PMID: 37156371</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers ; Endothelial Cells ; Endothelial dysfunction ; Endothelial glycocalyx ; Endothelium ; Glycocalyx ; Humans ; IL6 ; Interleukin-6 ; Major abdominal surgery ; Methylprednisolone ; Postoperative morbidity ; sThrombomodulin ; Surgical stress ; sVEGFR1 ; Syndecan-1</subject><ispartof>Microvascular research, 2023-07, Vol.148, p.104543-104543, Article 104543</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-bd21a7821b318abc54310f72f0dd7634d949477b96d1c3b4f96e04df6d8b12343</citedby><cites>FETCH-LOGICAL-c396t-bd21a7821b318abc54310f72f0dd7634d949477b96d1c3b4f96e04df6d8b12343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026286223000699$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37156371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gregersen, Jeppe Skovgaard</creatorcontrib><creatorcontrib>Bazancir, Laser Arif</creatorcontrib><creatorcontrib>Johansson, Pär Ingemar</creatorcontrib><creatorcontrib>Sørensen, Henrik</creatorcontrib><creatorcontrib>Achiam, Michael Patrick</creatorcontrib><creatorcontrib>Olsen, August Adelsten</creatorcontrib><title>Major open abdominal surgery is associated with increased levels of endothelial damage and interleukin-6</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>To examine changes in biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress following major open abdominal surgery and the correlation to postoperative morbidity.
Major abdominal surgery is associated with high levels of postoperative morbidity. Two possible reasons are the surgical stress response and the impairment of the glycocalyx and endothelial cells. Further, the degree of these responses may correlate with postoperative morbidity and complications.
A secondary data analysis of prospectively collected data from two cohorts of patients undergoing open liver surgery, gastrectomy, esophagectomy, or Whipple procedure (n = 112). Hemodynamics and blood samples were collected at predefined timestamps and analyzed for biomarkers of glycocalyx shedding (Syndecan-1), endothelial activation (sVEGFR1), endothelial damage (sThrombomodulin (sTM)), and surgical stress (IL6).
Major abdominal surgery led to increased levels of IL6 (0 to 85 pg/mL), Syndecan-1 (17.2 to 46.4 ng/mL), and sVEGFR1 (382.8 to 526.5 pg/mL), peaking at the end of the surgery. In contrast, sTM, did not increase during surgery, but increased significantly following surgery (5.9 to 6.9 ng/mL), peaking at 18 h following the end of surgery. Patients characterized with high postoperative morbidity had higher levels of IL6 (132 vs. 78 pg/mL, p = 0.007) and sVEGFR1 (563.1 vs. 509.4 pg/mL, p = 0.045) at the end of the surgery, and of sTM (8.2 vs. 6.4 ng/mL, p = 0.038) 18 h following surgery.
Major abdominal surgery leads to significantly increased levels of biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress, with the highest levels seen in patients developing high postoperative morbidity.
•Major abdominal surgery is associated with high levels of postoperative morbidity.•Corticosteroid did not affect the pathophysiology of high postoperative morbidity.•Increased sVEGFR1, sTM and IL6 are associated with high postoperative morbidity.•Major abdominal surgery leads to increased endothelial dysfunction.</description><subject>Biomarkers</subject><subject>Endothelial Cells</subject><subject>Endothelial dysfunction</subject><subject>Endothelial glycocalyx</subject><subject>Endothelium</subject><subject>Glycocalyx</subject><subject>Humans</subject><subject>IL6</subject><subject>Interleukin-6</subject><subject>Major abdominal surgery</subject><subject>Methylprednisolone</subject><subject>Postoperative morbidity</subject><subject>sThrombomodulin</subject><subject>Surgical stress</subject><subject>sVEGFR1</subject><subject>Syndecan-1</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-AC-So5eu-WjTBk8ifoHiRc8hTaZuatusSbuy_97Irh69zDDwvC_Mg9AZJQtKqLhsF_06LBhhPN15kfM9NKNEFpnkVO6jGSFMZKwS7Agdx9gSQmkh2SE64iUtRBoztHzWrQ_Yr2DAura-d4PucJzCO4QNdhHrGL1xegSLv9y4xG4wAXRMZwdr6CL2DYbB-nEJnUtRq3v9DlgPNqEjhA6mDzdk4gQdNLqLcLrbc_R2d_t685A9vdw_3lw_ZYZLMWa1ZVSXFaM1p5WuTXqKkqZkDbG2FDy3Mpd5WdZSWGp4nTdSAMltI2xVU8ZzPkcX295V8J8TxFH1LhroOj2An6JiVZIgRCHKhNItaoKPMUCjVsH1OmwUJepHsGpVEqx-BKut4JQ539VPdQ_2L_FrNAFXWyC5gbWDoKJxMBiwLoAZlfXun_pvn7-MEQ</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Gregersen, Jeppe Skovgaard</creator><creator>Bazancir, Laser Arif</creator><creator>Johansson, Pär Ingemar</creator><creator>Sørensen, Henrik</creator><creator>Achiam, Michael Patrick</creator><creator>Olsen, August Adelsten</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202307</creationdate><title>Major open abdominal surgery is associated with increased levels of endothelial damage and interleukin-6</title><author>Gregersen, Jeppe Skovgaard ; Bazancir, Laser Arif ; Johansson, Pär Ingemar ; Sørensen, Henrik ; Achiam, Michael Patrick ; Olsen, August Adelsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-bd21a7821b318abc54310f72f0dd7634d949477b96d1c3b4f96e04df6d8b12343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biomarkers</topic><topic>Endothelial Cells</topic><topic>Endothelial dysfunction</topic><topic>Endothelial glycocalyx</topic><topic>Endothelium</topic><topic>Glycocalyx</topic><topic>Humans</topic><topic>IL6</topic><topic>Interleukin-6</topic><topic>Major abdominal surgery</topic><topic>Methylprednisolone</topic><topic>Postoperative morbidity</topic><topic>sThrombomodulin</topic><topic>Surgical stress</topic><topic>sVEGFR1</topic><topic>Syndecan-1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gregersen, Jeppe Skovgaard</creatorcontrib><creatorcontrib>Bazancir, Laser Arif</creatorcontrib><creatorcontrib>Johansson, Pär Ingemar</creatorcontrib><creatorcontrib>Sørensen, Henrik</creatorcontrib><creatorcontrib>Achiam, Michael Patrick</creatorcontrib><creatorcontrib>Olsen, August Adelsten</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gregersen, Jeppe Skovgaard</au><au>Bazancir, Laser Arif</au><au>Johansson, Pär Ingemar</au><au>Sørensen, Henrik</au><au>Achiam, Michael Patrick</au><au>Olsen, August Adelsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major open abdominal surgery is associated with increased levels of endothelial damage and interleukin-6</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2023-07</date><risdate>2023</risdate><volume>148</volume><spage>104543</spage><epage>104543</epage><pages>104543-104543</pages><artnum>104543</artnum><issn>0026-2862</issn><eissn>1095-9319</eissn><abstract>To examine changes in biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress following major open abdominal surgery and the correlation to postoperative morbidity.
Major abdominal surgery is associated with high levels of postoperative morbidity. Two possible reasons are the surgical stress response and the impairment of the glycocalyx and endothelial cells. Further, the degree of these responses may correlate with postoperative morbidity and complications.
A secondary data analysis of prospectively collected data from two cohorts of patients undergoing open liver surgery, gastrectomy, esophagectomy, or Whipple procedure (n = 112). Hemodynamics and blood samples were collected at predefined timestamps and analyzed for biomarkers of glycocalyx shedding (Syndecan-1), endothelial activation (sVEGFR1), endothelial damage (sThrombomodulin (sTM)), and surgical stress (IL6).
Major abdominal surgery led to increased levels of IL6 (0 to 85 pg/mL), Syndecan-1 (17.2 to 46.4 ng/mL), and sVEGFR1 (382.8 to 526.5 pg/mL), peaking at the end of the surgery. In contrast, sTM, did not increase during surgery, but increased significantly following surgery (5.9 to 6.9 ng/mL), peaking at 18 h following the end of surgery. Patients characterized with high postoperative morbidity had higher levels of IL6 (132 vs. 78 pg/mL, p = 0.007) and sVEGFR1 (563.1 vs. 509.4 pg/mL, p = 0.045) at the end of the surgery, and of sTM (8.2 vs. 6.4 ng/mL, p = 0.038) 18 h following surgery.
Major abdominal surgery leads to significantly increased levels of biomarkers of endothelial glycocalyx shedding, endothelial damage, and surgical stress, with the highest levels seen in patients developing high postoperative morbidity.
•Major abdominal surgery is associated with high levels of postoperative morbidity.•Corticosteroid did not affect the pathophysiology of high postoperative morbidity.•Increased sVEGFR1, sTM and IL6 are associated with high postoperative morbidity.•Major abdominal surgery leads to increased endothelial dysfunction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37156371</pmid><doi>10.1016/j.mvr.2023.104543</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Microvascular research, 2023-07, Vol.148, p.104543-104543, Article 104543 |
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| subjects | Biomarkers Endothelial Cells Endothelial dysfunction Endothelial glycocalyx Endothelium Glycocalyx Humans IL6 Interleukin-6 Major abdominal surgery Methylprednisolone Postoperative morbidity sThrombomodulin Surgical stress sVEGFR1 Syndecan-1 |
| title | Major open abdominal surgery is associated with increased levels of endothelial damage and interleukin-6 |
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