Sustained Preservation of Cognition and Prevention of Patient-Reported Symptoms With Hippocampal Avoidance During Whole-Brain Radiation Therapy for Brain Metastases: Final Results of NRG Oncology CC001

Initial report of NRG Oncology CC001, a phase 3 trial of whole-brain radiation therapy plus memantine (WBRT + memantine) with or without hippocampal avoidance (HA), demonstrated neuroprotective effects of HA with a median follow-up of fewer than 8 months. Herein, we report the final results with com...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2023-11, Vol.117 (3), p.571-580
Hauptverfasser:	Gondi, Vinai, Deshmukh, Snehal, Brown, Paul D., Wefel, Jeffrey S., Armstrong, Terri S., Tome, Wolfgang A., Gilbert, Mark R., Konski, Andre, Robinson, Clifford G., Bovi, Joseph A., Benzinger, Tammie L.S., Roberge, David, Kundapur, Vijayananda, Kaufman, Isaac, Shah, Sunjay, Usuki, Kenneth Y., Baschnagel, Andrew M., Mehta, Minesh P., Kachnic, Lisa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brain Brain Neoplasms - secondary Cognition - radiation effects Cranial Irradiation - adverse effects Cranial Irradiation - methods Hippocampus Humans Memantine - therapeutic use
Online-Zugang:	Volltext
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