The first PET glimpse of a proton FLASH beam
We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a...
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| Veröffentlicht in: | Physics in medicine & biology 2023-06, Vol.68 (12), p.125001 |
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| creator | Abouzahr, F Cesar, J P Crespo, P Gajda, M Hu, Z Kaye, W Klein, K Kuo, A S Majewski, S Mawlawi, O Morozov, A Ojha, A Poenisch, F Polf, J C Proga, M Sahoo, N Seco, J Takaoka, T Tavernier, S Titt, U Wang, X Zhu, X R Lang, K |
| description | We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 10
protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy. |
| doi_str_mv | 10.1088/1361-6560/acd29e |
| format | Article |
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protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.</description><identifier>ISSN: 0031-9155</identifier><identifier>EISSN: 1361-6560</identifier><identifier>DOI: 10.1088/1361-6560/acd29e</identifier><identifier>PMID: 37141903</identifier><identifier>CODEN: PHMBA7</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>FLASH beam ; Monte Carlo Method ; PET ; PET dosimetry ; PET imaging ; Phantoms, Imaging ; Polymethyl Methacrylate ; Positron-Emission Tomography ; Proton Therapy ; Protons ; radiation oncology ; radiation treatment plan ; Radiometry</subject><ispartof>Physics in medicine & biology, 2023-06, Vol.68 (12), p.125001</ispartof><rights>2023 The Author(s). Published on behalf of Institute of Physics and Engineering in Medicine by IOP Publishing Ltd</rights><rights>Creative Commons Attribution license.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-7ff14f66bc7069e42c2bd2f948b78dd9e72d02eb704961fd0bba7aa6a1d953343</citedby><cites>FETCH-LOGICAL-c411t-7ff14f66bc7069e42c2bd2f948b78dd9e72d02eb704961fd0bba7aa6a1d953343</cites><orcidid>0000-0002-0891-032X ; 0009-0002-2147-0848 ; 0009-0005-6205-9512 ; 0000-0001-6644-0023 ; 0000-0001-5719-7105 ; 0000-0003-2429-9273 ; 0000-0003-1497-4327 ; 0000-0002-0303-5159 ; 0000-0001-6555-4977 ; 0000-0003-4219-4096 ; 0009-0004-8148-3012 ; 0000-0002-6792-9522 ; 0000-0002-7922-970X ; 0000-0001-6724-4913 ; 0000-0002-9458-2202 ; 0000-0002-5535-4418 ; 0000-0003-1269-7223 ; 0000-0003-4446-5670</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/1361-6560/acd29e/pdf$$EPDF$$P50$$Giop$$Hfree_for_read</linktopdf><link.rule.ids>314,776,780,27901,27902,53821,53868</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37141903$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abouzahr, F</creatorcontrib><creatorcontrib>Cesar, J P</creatorcontrib><creatorcontrib>Crespo, P</creatorcontrib><creatorcontrib>Gajda, M</creatorcontrib><creatorcontrib>Hu, Z</creatorcontrib><creatorcontrib>Kaye, W</creatorcontrib><creatorcontrib>Klein, K</creatorcontrib><creatorcontrib>Kuo, A S</creatorcontrib><creatorcontrib>Majewski, S</creatorcontrib><creatorcontrib>Mawlawi, O</creatorcontrib><creatorcontrib>Morozov, A</creatorcontrib><creatorcontrib>Ojha, A</creatorcontrib><creatorcontrib>Poenisch, F</creatorcontrib><creatorcontrib>Polf, J C</creatorcontrib><creatorcontrib>Proga, M</creatorcontrib><creatorcontrib>Sahoo, N</creatorcontrib><creatorcontrib>Seco, J</creatorcontrib><creatorcontrib>Takaoka, T</creatorcontrib><creatorcontrib>Tavernier, S</creatorcontrib><creatorcontrib>Titt, U</creatorcontrib><creatorcontrib>Wang, X</creatorcontrib><creatorcontrib>Zhu, X R</creatorcontrib><creatorcontrib>Lang, K</creatorcontrib><title>The first PET glimpse of a proton FLASH beam</title><title>Physics in medicine & biology</title><addtitle>PMB</addtitle><addtitle>Phys. Med. Biol</addtitle><description>We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 10
protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy.</description><subject>FLASH beam</subject><subject>Monte Carlo Method</subject><subject>PET</subject><subject>PET dosimetry</subject><subject>PET imaging</subject><subject>Phantoms, Imaging</subject><subject>Polymethyl Methacrylate</subject><subject>Positron-Emission Tomography</subject><subject>Proton Therapy</subject><subject>Protons</subject><subject>radiation oncology</subject><subject>radiation treatment plan</subject><subject>Radiometry</subject><issn>0031-9155</issn><issn>1361-6560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>O3W</sourceid><sourceid>EIF</sourceid><recordid>eNp1kEFLAzEQhYMotlbvniRHD12bSbLJ5lhKa4WCgvUckk2iW7rddbN78N-7pbVeFAYGhvfezHwI3QJ5AJJlE2ACEpEKMjG5o8qfoeFpdI6GhDBIFKTpAF3FuCEEIKP8Eg2YBA6KsCEarz88DkUTW_wyX-P3bVHW0eMqYIPrpmqrHV6spq9LbL0pr9FFMNvob459hN4W8_VsmayeH59m01WSc4A2kSEAD0LYXBKhPKc5tY4GxTMrM-eUl9QR6q0kXAkIjlhrpDHCgFMpY5yN0P0ht7_gs_Ox1WURc7_dmp2vuqhpBkRRJjn0UnKQ5k0VY-ODrpuiNM2XBqL3jPQeiN4D0QdGveXumN7Z0ruT4QfK7_qiqvWm6ppd_6yuS6tFH0f7SnuUunahl47_kP67-hsJnnr7</recordid><startdate>20230621</startdate><enddate>20230621</enddate><creator>Abouzahr, F</creator><creator>Cesar, J P</creator><creator>Crespo, P</creator><creator>Gajda, M</creator><creator>Hu, Z</creator><creator>Kaye, W</creator><creator>Klein, K</creator><creator>Kuo, A S</creator><creator>Majewski, S</creator><creator>Mawlawi, O</creator><creator>Morozov, A</creator><creator>Ojha, A</creator><creator>Poenisch, F</creator><creator>Polf, J C</creator><creator>Proga, M</creator><creator>Sahoo, N</creator><creator>Seco, J</creator><creator>Takaoka, T</creator><creator>Tavernier, S</creator><creator>Titt, U</creator><creator>Wang, X</creator><creator>Zhu, X R</creator><creator>Lang, K</creator><general>IOP Publishing</general><scope>O3W</scope><scope>TSCCA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0891-032X</orcidid><orcidid>https://orcid.org/0009-0002-2147-0848</orcidid><orcidid>https://orcid.org/0009-0005-6205-9512</orcidid><orcidid>https://orcid.org/0000-0001-6644-0023</orcidid><orcidid>https://orcid.org/0000-0001-5719-7105</orcidid><orcidid>https://orcid.org/0000-0003-2429-9273</orcidid><orcidid>https://orcid.org/0000-0003-1497-4327</orcidid><orcidid>https://orcid.org/0000-0002-0303-5159</orcidid><orcidid>https://orcid.org/0000-0001-6555-4977</orcidid><orcidid>https://orcid.org/0000-0003-4219-4096</orcidid><orcidid>https://orcid.org/0009-0004-8148-3012</orcidid><orcidid>https://orcid.org/0000-0002-6792-9522</orcidid><orcidid>https://orcid.org/0000-0002-7922-970X</orcidid><orcidid>https://orcid.org/0000-0001-6724-4913</orcidid><orcidid>https://orcid.org/0000-0002-9458-2202</orcidid><orcidid>https://orcid.org/0000-0002-5535-4418</orcidid><orcidid>https://orcid.org/0000-0003-1269-7223</orcidid><orcidid>https://orcid.org/0000-0003-4446-5670</orcidid></search><sort><creationdate>20230621</creationdate><title>The first PET glimpse of a proton FLASH beam</title><author>Abouzahr, F ; Cesar, J P ; Crespo, P ; Gajda, M ; Hu, Z ; Kaye, W ; Klein, K ; Kuo, A S ; Majewski, S ; Mawlawi, O ; Morozov, A ; Ojha, A ; Poenisch, F ; Polf, J C ; Proga, M ; Sahoo, N ; Seco, J ; Takaoka, T ; Tavernier, S ; Titt, U ; Wang, X ; Zhu, X R ; Lang, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-7ff14f66bc7069e42c2bd2f948b78dd9e72d02eb704961fd0bba7aa6a1d953343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>FLASH beam</topic><topic>Monte Carlo Method</topic><topic>PET</topic><topic>PET dosimetry</topic><topic>PET imaging</topic><topic>Phantoms, Imaging</topic><topic>Polymethyl Methacrylate</topic><topic>Positron-Emission Tomography</topic><topic>Proton Therapy</topic><topic>Protons</topic><topic>radiation oncology</topic><topic>radiation treatment plan</topic><topic>Radiometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abouzahr, F</creatorcontrib><creatorcontrib>Cesar, J P</creatorcontrib><creatorcontrib>Crespo, P</creatorcontrib><creatorcontrib>Gajda, M</creatorcontrib><creatorcontrib>Hu, Z</creatorcontrib><creatorcontrib>Kaye, W</creatorcontrib><creatorcontrib>Klein, K</creatorcontrib><creatorcontrib>Kuo, A S</creatorcontrib><creatorcontrib>Majewski, S</creatorcontrib><creatorcontrib>Mawlawi, O</creatorcontrib><creatorcontrib>Morozov, A</creatorcontrib><creatorcontrib>Ojha, A</creatorcontrib><creatorcontrib>Poenisch, F</creatorcontrib><creatorcontrib>Polf, J C</creatorcontrib><creatorcontrib>Proga, M</creatorcontrib><creatorcontrib>Sahoo, N</creatorcontrib><creatorcontrib>Seco, J</creatorcontrib><creatorcontrib>Takaoka, T</creatorcontrib><creatorcontrib>Tavernier, S</creatorcontrib><creatorcontrib>Titt, U</creatorcontrib><creatorcontrib>Wang, X</creatorcontrib><creatorcontrib>Zhu, X R</creatorcontrib><creatorcontrib>Lang, K</creatorcontrib><collection>IOP Publishing Free Content</collection><collection>IOPscience (Open Access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physics in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abouzahr, F</au><au>Cesar, J P</au><au>Crespo, P</au><au>Gajda, M</au><au>Hu, Z</au><au>Kaye, W</au><au>Klein, K</au><au>Kuo, A S</au><au>Majewski, S</au><au>Mawlawi, O</au><au>Morozov, A</au><au>Ojha, A</au><au>Poenisch, F</au><au>Polf, J C</au><au>Proga, M</au><au>Sahoo, N</au><au>Seco, J</au><au>Takaoka, T</au><au>Tavernier, S</au><au>Titt, U</au><au>Wang, X</au><au>Zhu, X R</au><au>Lang, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The first PET glimpse of a proton FLASH beam</atitle><jtitle>Physics in medicine & biology</jtitle><stitle>PMB</stitle><addtitle>Phys. 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| subjects | FLASH beam Monte Carlo Method PET PET dosimetry PET imaging Phantoms, Imaging Polymethyl Methacrylate Positron-Emission Tomography Proton Therapy Protons radiation oncology radiation treatment plan Radiometry |
| title | The first PET glimpse of a proton FLASH beam |
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