Associations of solar activity and related exposures with fetal growth
Solar and geomagnetic activity have been shown to suppress melatonin and to degrade folate levels, important hormones for fetal development. We examined whether solar and geomagnetic activity were associated with fetal growth. We included 9573 singleton births with 26,879 routine ultrasounds at an a...
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| Veröffentlicht in: | The Science of the total environment 2023-08, Vol.885, p.163862, Article 163862 |
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| creator | Wang, Veronica A. Leung, Michael Modest, Anna M. Zilli Vieira, Carolina L. Hacker, Michele R. Schwartz, Joel Coull, Brent A. Koutrakis, Petros Papatheodorou, Stefania |
| description | Solar and geomagnetic activity have been shown to suppress melatonin and to degrade folate levels, important hormones for fetal development. We examined whether solar and geomagnetic activity were associated with fetal growth.
We included 9573 singleton births with 26,879 routine ultrasounds at an academic medical center in Eastern Massachusetts from 2011 through 2016. Sunspot number and Kp index were obtained from the NASA Goddard Space Flight Center. Three exposure windows were considered, including the first 16 weeks of pregnancy, one month prior to fetal growth measurement, and conception until fetal growth measurement (cumulative). Ultrasound scans from which we extracted biparietal diameter, head circumference, femur length, and abdominal circumference measurements were categorized as anatomic ( |
| doi_str_mv | 10.1016/j.scitotenv.2023.163862 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2810923676</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S004896972302483X</els_id><sourcerecordid>2810923676</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-cbbb22e63cbd55d5073066f785c13510b6efcec61c6eefd462a384d7b8b5c9b73</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EouXxC-AlmxQ_EjtZVhUFJCQ2sLb8mFBXaVxst4W_J1ULW2Yzm3Pnag5Ct5RMKKHifjlJ1ueQod9OGGF8QgWvBTtBY1rLpqCEiVM0JqSsi0Y0coQuUlqSYWRNz9GIS1oyUtIxmk9TCtbr7EOfcGhxCp2OWNvstz5_Y907HKHTGRyGr3VImwgJ73xe4Bay7vBHDLu8uEJnre4SXB_3JXqfP7zNnoqX18fn2fSlsENfLqwxhjEQ3BpXVa4ikhMhWllXlvKKEiOgtWAFtQKgdaVgmtelk6Y2lW2M5Jfo7nB3HcPnBlJWK58sdJ3uIWySYjUlDeNCigGVB9TGkFKEVq2jX-n4rShRe4lqqf4kqr1EdZA4JG-OJRuzAveX-7U2ANMDAMOrWw9xfwh6C85HsFm54P8t-QFgNIip</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2810923676</pqid></control><display><type>article</type><title>Associations of solar activity and related exposures with fetal growth</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Wang, Veronica A. ; Leung, Michael ; Modest, Anna M. ; Zilli Vieira, Carolina L. ; Hacker, Michele R. ; Schwartz, Joel ; Coull, Brent A. ; Koutrakis, Petros ; Papatheodorou, Stefania</creator><creatorcontrib>Wang, Veronica A. ; Leung, Michael ; Modest, Anna M. ; Zilli Vieira, Carolina L. ; Hacker, Michele R. ; Schwartz, Joel ; Coull, Brent A. ; Koutrakis, Petros ; Papatheodorou, Stefania</creatorcontrib><description>Solar and geomagnetic activity have been shown to suppress melatonin and to degrade folate levels, important hormones for fetal development. We examined whether solar and geomagnetic activity were associated with fetal growth.
We included 9573 singleton births with 26,879 routine ultrasounds at an academic medical center in Eastern Massachusetts from 2011 through 2016. Sunspot number and Kp index were obtained from the NASA Goddard Space Flight Center. Three exposure windows were considered, including the first 16 weeks of pregnancy, one month prior to fetal growth measurement, and conception until fetal growth measurement (cumulative). Ultrasound scans from which we extracted biparietal diameter, head circumference, femur length, and abdominal circumference measurements were categorized as anatomic (<24 weeks' gestation) or growth scans (≥24 weeks' gestation) based on clinical practice. Ultrasound parameters and birth weight were standardized, and linear mixed models adjusted for long-term trends were fitted.
Prenatal exposures were positively associated with larger head parameters measured <24 weeks' gestation, negatively associated with smaller fetal parameters measured ≥24 weeks' gestation, and not associated with birth weight. The strongest associations were observed for cumulative exposure in growth scans, where an interquartile range increase in sunspot number (32.87 sunspots) was associated with a −0.17 (95 % CI: −0.26, −0.08), −0.25 (−0.36, −0.15), and −0.13 (95 % CI: −0.23, −0.03) difference in mean biparietal diameter, head circumference, and femur length z-score, respectively. An interquartile range increase in cumulative Kp index (0.49) was associated with a −0.11 (95 % CI: −0.22, −0.01) and −0.11 (95 % CI: −0.20, −0.02) difference in mean head circumference and abdominal circumference z-score, respectively, in growth scans.
Solar and geomagnetic activity were associated with fetal growth. Future studies are needed to better understand the impact of these natural phenomena on clinical endpoints.
[Display omitted]
•Kp index was positively associated with head parameters in anatomic scans.•Sunspot number and Kp index were negatively associated with growth scan parameters.•Particulate air pollution did not mediate solar activity-fetal growth associations.•White participants and male fetuses may be particularly vulnerable to solar activity.</description><identifier>ISSN: 0048-9697</identifier><identifier>ISSN: 1879-1026</identifier><identifier>EISSN: 1879-1026</identifier><identifier>DOI: 10.1016/j.scitotenv.2023.163862</identifier><identifier>PMID: 37142041</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Birth Weight ; Female ; Fetal Development ; Fetal growth ; Geomagnetic disturbances ; Gestational Age ; Humans ; Pregnancy ; Pregnancy outcomes ; Solar Activity ; Ultrasonography, Prenatal</subject><ispartof>The Science of the total environment, 2023-08, Vol.885, p.163862, Article 163862</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-cbbb22e63cbd55d5073066f785c13510b6efcec61c6eefd462a384d7b8b5c9b73</citedby><cites>FETCH-LOGICAL-c420t-cbbb22e63cbd55d5073066f785c13510b6efcec61c6eefd462a384d7b8b5c9b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.scitotenv.2023.163862$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37142041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Veronica A.</creatorcontrib><creatorcontrib>Leung, Michael</creatorcontrib><creatorcontrib>Modest, Anna M.</creatorcontrib><creatorcontrib>Zilli Vieira, Carolina L.</creatorcontrib><creatorcontrib>Hacker, Michele R.</creatorcontrib><creatorcontrib>Schwartz, Joel</creatorcontrib><creatorcontrib>Coull, Brent A.</creatorcontrib><creatorcontrib>Koutrakis, Petros</creatorcontrib><creatorcontrib>Papatheodorou, Stefania</creatorcontrib><title>Associations of solar activity and related exposures with fetal growth</title><title>The Science of the total environment</title><addtitle>Sci Total Environ</addtitle><description>Solar and geomagnetic activity have been shown to suppress melatonin and to degrade folate levels, important hormones for fetal development. We examined whether solar and geomagnetic activity were associated with fetal growth.
We included 9573 singleton births with 26,879 routine ultrasounds at an academic medical center in Eastern Massachusetts from 2011 through 2016. Sunspot number and Kp index were obtained from the NASA Goddard Space Flight Center. Three exposure windows were considered, including the first 16 weeks of pregnancy, one month prior to fetal growth measurement, and conception until fetal growth measurement (cumulative). Ultrasound scans from which we extracted biparietal diameter, head circumference, femur length, and abdominal circumference measurements were categorized as anatomic (<24 weeks' gestation) or growth scans (≥24 weeks' gestation) based on clinical practice. Ultrasound parameters and birth weight were standardized, and linear mixed models adjusted for long-term trends were fitted.
Prenatal exposures were positively associated with larger head parameters measured <24 weeks' gestation, negatively associated with smaller fetal parameters measured ≥24 weeks' gestation, and not associated with birth weight. The strongest associations were observed for cumulative exposure in growth scans, where an interquartile range increase in sunspot number (32.87 sunspots) was associated with a −0.17 (95 % CI: −0.26, −0.08), −0.25 (−0.36, −0.15), and −0.13 (95 % CI: −0.23, −0.03) difference in mean biparietal diameter, head circumference, and femur length z-score, respectively. An interquartile range increase in cumulative Kp index (0.49) was associated with a −0.11 (95 % CI: −0.22, −0.01) and −0.11 (95 % CI: −0.20, −0.02) difference in mean head circumference and abdominal circumference z-score, respectively, in growth scans.
Solar and geomagnetic activity were associated with fetal growth. Future studies are needed to better understand the impact of these natural phenomena on clinical endpoints.
[Display omitted]
•Kp index was positively associated with head parameters in anatomic scans.•Sunspot number and Kp index were negatively associated with growth scan parameters.•Particulate air pollution did not mediate solar activity-fetal growth associations.•White participants and male fetuses may be particularly vulnerable to solar activity.</description><subject>Birth Weight</subject><subject>Female</subject><subject>Fetal Development</subject><subject>Fetal growth</subject><subject>Geomagnetic disturbances</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Pregnancy</subject><subject>Pregnancy outcomes</subject><subject>Solar Activity</subject><subject>Ultrasonography, Prenatal</subject><issn>0048-9697</issn><issn>1879-1026</issn><issn>1879-1026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EouXxC-AlmxQ_EjtZVhUFJCQ2sLb8mFBXaVxst4W_J1ULW2Yzm3Pnag5Ct5RMKKHifjlJ1ueQod9OGGF8QgWvBTtBY1rLpqCEiVM0JqSsi0Y0coQuUlqSYWRNz9GIS1oyUtIxmk9TCtbr7EOfcGhxCp2OWNvstz5_Y907HKHTGRyGr3VImwgJ73xe4Bay7vBHDLu8uEJnre4SXB_3JXqfP7zNnoqX18fn2fSlsENfLqwxhjEQ3BpXVa4ikhMhWllXlvKKEiOgtWAFtQKgdaVgmtelk6Y2lW2M5Jfo7nB3HcPnBlJWK58sdJ3uIWySYjUlDeNCigGVB9TGkFKEVq2jX-n4rShRe4lqqf4kqr1EdZA4JG-OJRuzAveX-7U2ANMDAMOrWw9xfwh6C85HsFm54P8t-QFgNIip</recordid><startdate>20230810</startdate><enddate>20230810</enddate><creator>Wang, Veronica A.</creator><creator>Leung, Michael</creator><creator>Modest, Anna M.</creator><creator>Zilli Vieira, Carolina L.</creator><creator>Hacker, Michele R.</creator><creator>Schwartz, Joel</creator><creator>Coull, Brent A.</creator><creator>Koutrakis, Petros</creator><creator>Papatheodorou, Stefania</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230810</creationdate><title>Associations of solar activity and related exposures with fetal growth</title><author>Wang, Veronica A. ; Leung, Michael ; Modest, Anna M. ; Zilli Vieira, Carolina L. ; Hacker, Michele R. ; Schwartz, Joel ; Coull, Brent A. ; Koutrakis, Petros ; Papatheodorou, Stefania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-cbbb22e63cbd55d5073066f785c13510b6efcec61c6eefd462a384d7b8b5c9b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Birth Weight</topic><topic>Female</topic><topic>Fetal Development</topic><topic>Fetal growth</topic><topic>Geomagnetic disturbances</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Pregnancy</topic><topic>Pregnancy outcomes</topic><topic>Solar Activity</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Veronica A.</creatorcontrib><creatorcontrib>Leung, Michael</creatorcontrib><creatorcontrib>Modest, Anna M.</creatorcontrib><creatorcontrib>Zilli Vieira, Carolina L.</creatorcontrib><creatorcontrib>Hacker, Michele R.</creatorcontrib><creatorcontrib>Schwartz, Joel</creatorcontrib><creatorcontrib>Coull, Brent A.</creatorcontrib><creatorcontrib>Koutrakis, Petros</creatorcontrib><creatorcontrib>Papatheodorou, Stefania</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Science of the total environment</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Veronica A.</au><au>Leung, Michael</au><au>Modest, Anna M.</au><au>Zilli Vieira, Carolina L.</au><au>Hacker, Michele R.</au><au>Schwartz, Joel</au><au>Coull, Brent A.</au><au>Koutrakis, Petros</au><au>Papatheodorou, Stefania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of solar activity and related exposures with fetal growth</atitle><jtitle>The Science of the total environment</jtitle><addtitle>Sci Total Environ</addtitle><date>2023-08-10</date><risdate>2023</risdate><volume>885</volume><spage>163862</spage><pages>163862-</pages><artnum>163862</artnum><issn>0048-9697</issn><issn>1879-1026</issn><eissn>1879-1026</eissn><abstract>Solar and geomagnetic activity have been shown to suppress melatonin and to degrade folate levels, important hormones for fetal development. We examined whether solar and geomagnetic activity were associated with fetal growth.
We included 9573 singleton births with 26,879 routine ultrasounds at an academic medical center in Eastern Massachusetts from 2011 through 2016. Sunspot number and Kp index were obtained from the NASA Goddard Space Flight Center. Three exposure windows were considered, including the first 16 weeks of pregnancy, one month prior to fetal growth measurement, and conception until fetal growth measurement (cumulative). Ultrasound scans from which we extracted biparietal diameter, head circumference, femur length, and abdominal circumference measurements were categorized as anatomic (<24 weeks' gestation) or growth scans (≥24 weeks' gestation) based on clinical practice. Ultrasound parameters and birth weight were standardized, and linear mixed models adjusted for long-term trends were fitted.
Prenatal exposures were positively associated with larger head parameters measured <24 weeks' gestation, negatively associated with smaller fetal parameters measured ≥24 weeks' gestation, and not associated with birth weight. The strongest associations were observed for cumulative exposure in growth scans, where an interquartile range increase in sunspot number (32.87 sunspots) was associated with a −0.17 (95 % CI: −0.26, −0.08), −0.25 (−0.36, −0.15), and −0.13 (95 % CI: −0.23, −0.03) difference in mean biparietal diameter, head circumference, and femur length z-score, respectively. An interquartile range increase in cumulative Kp index (0.49) was associated with a −0.11 (95 % CI: −0.22, −0.01) and −0.11 (95 % CI: −0.20, −0.02) difference in mean head circumference and abdominal circumference z-score, respectively, in growth scans.
Solar and geomagnetic activity were associated with fetal growth. Future studies are needed to better understand the impact of these natural phenomena on clinical endpoints.
[Display omitted]
•Kp index was positively associated with head parameters in anatomic scans.•Sunspot number and Kp index were negatively associated with growth scan parameters.•Particulate air pollution did not mediate solar activity-fetal growth associations.•White participants and male fetuses may be particularly vulnerable to solar activity.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37142041</pmid><doi>10.1016/j.scitotenv.2023.163862</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Birth Weight Female Fetal Development Fetal growth Geomagnetic disturbances Gestational Age Humans Pregnancy Pregnancy outcomes Solar Activity Ultrasonography, Prenatal |
| title | Associations of solar activity and related exposures with fetal growth |
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