Evaluating the inhibitory activity of ferrocenyl Schiff bases derivatives on 5-lipoxygenase: Computational and biological studies

In the search for new 5-LOX inhibitors, two ferrocenyl Schiff base complexes functionalized with catechol ((ƞ5-(E)-C5H4-NCH-3,4-benzodiol)Fe(ƞ5-C5H5) (3a)) and vanillin ((ƞ5-(E)-C5H4-NCH-3-methoxy-4-phenol)Fe(ƞ5-C5H5) (3b)) were obtained. Complexes 3a and 3b were biologically evaluated as 5-LOX inhi...

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Veröffentlicht in:	Journal of inorganic biochemistry 2023-08, Vol.245, p.112233-112233, Article 112233
Hauptverfasser:	Navarrete, Elizabeth, Morales, Pilar, Muñoz-Osses, Michelle, Vásquez-Martínez, Yesseny, Godoy, Fernando, Maldonado, Tamara, Martí, Angel A., Flores, Erick, Mascayano, Carolina
Format:	Artikel
Sprache:	eng
Schlagworte:	5-LOX inhibition Arachidonate 5-Lipoxygenase - chemistry Arachidonate 5-Lipoxygenase - metabolism Electrochemical analysis Ferric Compounds Ferrocenyl complexes Lipoxygenase Inhibitors - pharmacology Metalloenzyme Molecular dynamic Molecular Dynamics Simulation Oxidation-Reduction Schiff base Schiff Bases - chemistry Schiff Bases - pharmacology Structure-Activity Relationship
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