Addiction neuroscience goes nuclear: A role for the transcription factor RXRα
Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron1 on the role of a specific nuclear receptor, RXRα. Results demonstrate that modifying accumbens RXRα expression profoundly alters gene transcription, neuronal activi...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2023-05, Vol.111 (9), p.1351-1353 |
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| container_issue | 9 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Pierce, R. Christopher Rich, Matthew T. Swinford-Jackson, Sarah E. |
| description | Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron1 on the role of a specific nuclear receptor, RXRα. Results demonstrate that modifying accumbens RXRα expression profoundly alters gene transcription, neuronal activity, and cocaine-induced behavioral responses.
Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron1 on the role of a specific nuclear receptor, RXRα. Results demonstrate that modifying accumbens RXRα expression profoundly alters gene transcription, neuronal activity, and cocaine-induced behavioral responses. |
| doi_str_mv | 10.1016/j.neuron.2023.04.002 |
| format | Article |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cell Nucleus - metabolism Cocaine - pharmacology Gene Expression Regulation Mice Receptors, Cytoplasmic and Nuclear Retinoid X Receptor alpha - metabolism Transcription Factors - metabolism |
| title | Addiction neuroscience goes nuclear: A role for the transcription factor RXRα |
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