Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children
Background Alterations in eating behavior are common in infants with intrauterine growth restriction (IUGR); omega-3 polyunsaturated fatty acids (PUFA) could provide protection. We hypothesized that those born IUGR with a genetic background associated with increased production of omega-3-PUFA will h...
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| Veröffentlicht in: | Pediatric research 2023-09, Vol.94 (3), p.1225-1234 |
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| creator | Jaramillo-Ospina, Angela M. Roman, Gabriel T. Rodrigues, Danitsa M. Patel, Sachin Pokhvisneva, Irina Chakr, Valentina G. Levitan, Robert D. Meaney, Michael J. Silveira, Patricia P. |
| description | Background
Alterations in eating behavior are common in infants with intrauterine growth restriction (IUGR); omega-3 polyunsaturated fatty acids (PUFA) could provide protection. We hypothesized that those born IUGR with a genetic background associated with increased production of omega-3-PUFA will have more adaptive eating behaviors during childhood.
Methods
IUGR/non-IUGR classified infants from MAVAN and GUSTO cohorts were included at the age of 4 and 5 years, respectively. Their parents reported child’s eating behaviors using the child eating behavior questionnaire-CEBQ. Based on the GWAS on serum PUFA (Coltell 2020), three polygenic scores were calculated.
Results
Significant interactions between IUGR and polygenic score for omega-3-PUFA on emotional overeating (
β
= –0.15,
P
= 0.049 GUSTO) and between IUGR and polygenic score for omega-6/omega-3-PUFA on desire to drink (
β
= 0.35,
P
= 0.044 MAVAN), pro-intake/anti-intake ratio (
β
= 0.10,
P
= 0.042 MAVAN), and emotional overeating (
β
= 0.16,
P
= 0.043 GUSTO) were found. Only in IUGR, a higher polygenic score for omega-3-PUFA associated with lower emotional overeating, while a higher polygenic score for omega-6/omega-3-PUFA ratio was associated with a higher desire to drink, emotional overeating, and pro-intake/anti-intake.
Conclusion
Only in IUGR, the genetic background for higher omega-3-PUFA is associated with protection against altered eating behavior, while the genetic score for a higher omega-6/omega-3-PUFA ratio is associated with altered eating behavior.
Impact
A genetic background related to a higher polygenic score for omega-3 PUFA protected infants born IUGR against eating behavior alterations, while a higher polygenic score for omega-6/omega-3 PUFA ratio increased the risk of having eating behavior alterations only in infants born IUGR, irrespective of their adiposity in childhood.
Genetic individual differences modify the effect of being born IUGR on eating outcomes, increasing the vulnerability/resilience to eating disorders in IUGR group and likely contributing to their risk for developing metabolic diseases later in life. |
| doi_str_mv | 10.1038/s41390-023-02609-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2810922335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2854685843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-91956cbe0f3fd7a043d7be2d72791e0f7040ce3b75cc0bd12c2ec34d99e92fa83</originalsourceid><addsrcrecordid>eNp9kU1vFDEMhqOqiC6FP9ADitQLlwEnznzkiKryIVXqhZ6jTMYzm3Y2syQZ0P57UrYFiQNSokj249eOX8YuBLwXgN2HpARqqEBiuQ3o6nDCNqLGElKqPWUbABQVat2dsVcp3QMIVXfqJTvDVijZ1LBhD7c7mmyFfL_Mh4mCdzy5JRLfxyWTy4nbyfqQMrdzpkgDJ5t9mHhPW_vDL5H7UE6Odi1pH4hPcfmZt1WklKN3uVS4rZ-HSOE1ezHaOdGbp_ec3X26_nb1pbq5_fz16uNN5VA2udJC143rCUYch9aCwqHtSQ6tbLUo0RYUOMK-rZ2DfhDSSXKoBq1Jy9F2eM7eHXXLH76vZQ6z88nRPNtAy5qM7ARoKRHrgl7-g94vawxlukLVqunKvrBQ8ki5uKQUaTT76Hc2HowA82iFOVphihXmtxXmUIrePkmv_Y6GPyXPuy8AHoFUUmGi-Lf3f2R_ATPjlm8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2854685843</pqid></control><display><type>article</type><title>Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Jaramillo-Ospina, Angela M. ; Roman, Gabriel T. ; Rodrigues, Danitsa M. ; Patel, Sachin ; Pokhvisneva, Irina ; Chakr, Valentina G. ; Levitan, Robert D. ; Meaney, Michael J. ; Silveira, Patricia P.</creator><creatorcontrib>Jaramillo-Ospina, Angela M. ; Roman, Gabriel T. ; Rodrigues, Danitsa M. ; Patel, Sachin ; Pokhvisneva, Irina ; Chakr, Valentina G. ; Levitan, Robert D. ; Meaney, Michael J. ; Silveira, Patricia P.</creatorcontrib><description>Background
Alterations in eating behavior are common in infants with intrauterine growth restriction (IUGR); omega-3 polyunsaturated fatty acids (PUFA) could provide protection. We hypothesized that those born IUGR with a genetic background associated with increased production of omega-3-PUFA will have more adaptive eating behaviors during childhood.
Methods
IUGR/non-IUGR classified infants from MAVAN and GUSTO cohorts were included at the age of 4 and 5 years, respectively. Their parents reported child’s eating behaviors using the child eating behavior questionnaire-CEBQ. Based on the GWAS on serum PUFA (Coltell 2020), three polygenic scores were calculated.
Results
Significant interactions between IUGR and polygenic score for omega-3-PUFA on emotional overeating (
β
= –0.15,
P
= 0.049 GUSTO) and between IUGR and polygenic score for omega-6/omega-3-PUFA on desire to drink (
β
= 0.35,
P
= 0.044 MAVAN), pro-intake/anti-intake ratio (
β
= 0.10,
P
= 0.042 MAVAN), and emotional overeating (
β
= 0.16,
P
= 0.043 GUSTO) were found. Only in IUGR, a higher polygenic score for omega-3-PUFA associated with lower emotional overeating, while a higher polygenic score for omega-6/omega-3-PUFA ratio was associated with a higher desire to drink, emotional overeating, and pro-intake/anti-intake.
Conclusion
Only in IUGR, the genetic background for higher omega-3-PUFA is associated with protection against altered eating behavior, while the genetic score for a higher omega-6/omega-3-PUFA ratio is associated with altered eating behavior.
Impact
A genetic background related to a higher polygenic score for omega-3 PUFA protected infants born IUGR against eating behavior alterations, while a higher polygenic score for omega-6/omega-3 PUFA ratio increased the risk of having eating behavior alterations only in infants born IUGR, irrespective of their adiposity in childhood.
Genetic individual differences modify the effect of being born IUGR on eating outcomes, increasing the vulnerability/resilience to eating disorders in IUGR group and likely contributing to their risk for developing metabolic diseases later in life.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/s41390-023-02609-y</identifier><identifier>PMID: 37142650</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Eating behavior ; Medicine ; Medicine & Public Health ; Pediatric Surgery ; Pediatrics ; Population Study Article</subject><ispartof>Pediatric research, 2023-09, Vol.94 (3), p.1225-1234</ispartof><rights>The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-91956cbe0f3fd7a043d7be2d72791e0f7040ce3b75cc0bd12c2ec34d99e92fa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37142650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jaramillo-Ospina, Angela M.</creatorcontrib><creatorcontrib>Roman, Gabriel T.</creatorcontrib><creatorcontrib>Rodrigues, Danitsa M.</creatorcontrib><creatorcontrib>Patel, Sachin</creatorcontrib><creatorcontrib>Pokhvisneva, Irina</creatorcontrib><creatorcontrib>Chakr, Valentina G.</creatorcontrib><creatorcontrib>Levitan, Robert D.</creatorcontrib><creatorcontrib>Meaney, Michael J.</creatorcontrib><creatorcontrib>Silveira, Patricia P.</creatorcontrib><title>Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Alterations in eating behavior are common in infants with intrauterine growth restriction (IUGR); omega-3 polyunsaturated fatty acids (PUFA) could provide protection. We hypothesized that those born IUGR with a genetic background associated with increased production of omega-3-PUFA will have more adaptive eating behaviors during childhood.
Methods
IUGR/non-IUGR classified infants from MAVAN and GUSTO cohorts were included at the age of 4 and 5 years, respectively. Their parents reported child’s eating behaviors using the child eating behavior questionnaire-CEBQ. Based on the GWAS on serum PUFA (Coltell 2020), three polygenic scores were calculated.
Results
Significant interactions between IUGR and polygenic score for omega-3-PUFA on emotional overeating (
β
= –0.15,
P
= 0.049 GUSTO) and between IUGR and polygenic score for omega-6/omega-3-PUFA on desire to drink (
β
= 0.35,
P
= 0.044 MAVAN), pro-intake/anti-intake ratio (
β
= 0.10,
P
= 0.042 MAVAN), and emotional overeating (
β
= 0.16,
P
= 0.043 GUSTO) were found. Only in IUGR, a higher polygenic score for omega-3-PUFA associated with lower emotional overeating, while a higher polygenic score for omega-6/omega-3-PUFA ratio was associated with a higher desire to drink, emotional overeating, and pro-intake/anti-intake.
Conclusion
Only in IUGR, the genetic background for higher omega-3-PUFA is associated with protection against altered eating behavior, while the genetic score for a higher omega-6/omega-3-PUFA ratio is associated with altered eating behavior.
Impact
A genetic background related to a higher polygenic score for omega-3 PUFA protected infants born IUGR against eating behavior alterations, while a higher polygenic score for omega-6/omega-3 PUFA ratio increased the risk of having eating behavior alterations only in infants born IUGR, irrespective of their adiposity in childhood.
Genetic individual differences modify the effect of being born IUGR on eating outcomes, increasing the vulnerability/resilience to eating disorders in IUGR group and likely contributing to their risk for developing metabolic diseases later in life.</description><subject>Eating behavior</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Population Study Article</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1vFDEMhqOqiC6FP9ADitQLlwEnznzkiKryIVXqhZ6jTMYzm3Y2syQZ0P57UrYFiQNSokj249eOX8YuBLwXgN2HpARqqEBiuQ3o6nDCNqLGElKqPWUbABQVat2dsVcp3QMIVXfqJTvDVijZ1LBhD7c7mmyFfL_Mh4mCdzy5JRLfxyWTy4nbyfqQMrdzpkgDJ5t9mHhPW_vDL5H7UE6Odi1pH4hPcfmZt1WklKN3uVS4rZ-HSOE1ezHaOdGbp_ec3X26_nb1pbq5_fz16uNN5VA2udJC143rCUYch9aCwqHtSQ6tbLUo0RYUOMK-rZ2DfhDSSXKoBq1Jy9F2eM7eHXXLH76vZQ6z88nRPNtAy5qM7ARoKRHrgl7-g94vawxlukLVqunKvrBQ8ki5uKQUaTT76Hc2HowA82iFOVphihXmtxXmUIrePkmv_Y6GPyXPuy8AHoFUUmGi-Lf3f2R_ATPjlm8</recordid><startdate>20230901</startdate><enddate>20230901</enddate><creator>Jaramillo-Ospina, Angela M.</creator><creator>Roman, Gabriel T.</creator><creator>Rodrigues, Danitsa M.</creator><creator>Patel, Sachin</creator><creator>Pokhvisneva, Irina</creator><creator>Chakr, Valentina G.</creator><creator>Levitan, Robert D.</creator><creator>Meaney, Michael J.</creator><creator>Silveira, Patricia P.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230901</creationdate><title>Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children</title><author>Jaramillo-Ospina, Angela M. ; Roman, Gabriel T. ; Rodrigues, Danitsa M. ; Patel, Sachin ; Pokhvisneva, Irina ; Chakr, Valentina G. ; Levitan, Robert D. ; Meaney, Michael J. ; Silveira, Patricia P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-91956cbe0f3fd7a043d7be2d72791e0f7040ce3b75cc0bd12c2ec34d99e92fa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Eating behavior</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Population Study Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jaramillo-Ospina, Angela M.</creatorcontrib><creatorcontrib>Roman, Gabriel T.</creatorcontrib><creatorcontrib>Rodrigues, Danitsa M.</creatorcontrib><creatorcontrib>Patel, Sachin</creatorcontrib><creatorcontrib>Pokhvisneva, Irina</creatorcontrib><creatorcontrib>Chakr, Valentina G.</creatorcontrib><creatorcontrib>Levitan, Robert D.</creatorcontrib><creatorcontrib>Meaney, Michael J.</creatorcontrib><creatorcontrib>Silveira, Patricia P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jaramillo-Ospina, Angela M.</au><au>Roman, Gabriel T.</au><au>Rodrigues, Danitsa M.</au><au>Patel, Sachin</au><au>Pokhvisneva, Irina</au><au>Chakr, Valentina G.</au><au>Levitan, Robert D.</au><au>Meaney, Michael J.</au><au>Silveira, Patricia P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2023-09-01</date><risdate>2023</risdate><volume>94</volume><issue>3</issue><spage>1225</spage><epage>1234</epage><pages>1225-1234</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Alterations in eating behavior are common in infants with intrauterine growth restriction (IUGR); omega-3 polyunsaturated fatty acids (PUFA) could provide protection. We hypothesized that those born IUGR with a genetic background associated with increased production of omega-3-PUFA will have more adaptive eating behaviors during childhood.
Methods
IUGR/non-IUGR classified infants from MAVAN and GUSTO cohorts were included at the age of 4 and 5 years, respectively. Their parents reported child’s eating behaviors using the child eating behavior questionnaire-CEBQ. Based on the GWAS on serum PUFA (Coltell 2020), three polygenic scores were calculated.
Results
Significant interactions between IUGR and polygenic score for omega-3-PUFA on emotional overeating (
β
= –0.15,
P
= 0.049 GUSTO) and between IUGR and polygenic score for omega-6/omega-3-PUFA on desire to drink (
β
= 0.35,
P
= 0.044 MAVAN), pro-intake/anti-intake ratio (
β
= 0.10,
P
= 0.042 MAVAN), and emotional overeating (
β
= 0.16,
P
= 0.043 GUSTO) were found. Only in IUGR, a higher polygenic score for omega-3-PUFA associated with lower emotional overeating, while a higher polygenic score for omega-6/omega-3-PUFA ratio was associated with a higher desire to drink, emotional overeating, and pro-intake/anti-intake.
Conclusion
Only in IUGR, the genetic background for higher omega-3-PUFA is associated with protection against altered eating behavior, while the genetic score for a higher omega-6/omega-3-PUFA ratio is associated with altered eating behavior.
Impact
A genetic background related to a higher polygenic score for omega-3 PUFA protected infants born IUGR against eating behavior alterations, while a higher polygenic score for omega-6/omega-3 PUFA ratio increased the risk of having eating behavior alterations only in infants born IUGR, irrespective of their adiposity in childhood.
Genetic individual differences modify the effect of being born IUGR on eating outcomes, increasing the vulnerability/resilience to eating disorders in IUGR group and likely contributing to their risk for developing metabolic diseases later in life.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>37142650</pmid><doi>10.1038/s41390-023-02609-y</doi><tpages>10</tpages></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Eating behavior Medicine Medicine & Public Health Pediatric Surgery Pediatrics Population Study Article |
| title | Omega-3 polygenic score protects against altered eating behavior in intrauterine growth-restricted children |
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