Liquid crystalline nanoparticles enable a multifunctional approach for topical psoriasis therapy by co-delivering triptolide and siRNAs

Schematic illustration of the multifunctional-LCN production and intracellular delivery. siTNF-α and siIL-6 promote cleavage of the messenger RNA (mRNA) target of TNF- α and IL-6 proteins, leading to downregulation of these proteins and reducing extracellular levels. Additionally, TP acts on subunit...

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Veröffentlicht in:	International journal of pharmaceutics 2023-06, Vol.640, p.123019-123019, Article 123019
Hauptverfasser:	Silvestrini, Ana Vitória Pupo, Garcia Praça, Fabíola, Leite, Marcel Nani, de Abreu Fantini, Márcia Carvalho, Frade, Marco Andrey Cipriani, Badra Bentley, Maria Vitória Lopes
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Interleukin-6 Liquid crystalline nanoparticle Nanoparticles - chemistry Psoriasis Psoriasis - drug therapy RNA, Small Interfering Scattering, Small Angle Skin delivery Small interfering RNA Swine Triptolide Tumor Necrosis Factor-alpha X-Ray Diffraction
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