Exploring the mechanism by which quercetin re-sensitizes breast cancer to paclitaxel: network pharmacology, molecular docking, and experimental verification

This study is aimed to explore the potential molecular mechanism of quercetin reversing paclitaxel (PTX) resistance in breast cancer (BC) by network pharmacology, molecular docking, and experimental verification. Pharmacological platform databases are used to predict quercetin targets and BC PTX-res...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2023-11, Vol.396 (11), p.3045-3059
Hauptverfasser:	Yang, Ye, Yan, Jiaoyan, Huang, Jian, Wu, Xiangyi, Yuan, Yan, Zhang, Shu, Mo, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomedical and Life Sciences Biomedicine Breast cancer Cell proliferation Chemosensitization Epidermal growth factor receptors ErbB Receptors Gene expression Genomes Molecular Docking Simulation Molecular modelling Neoplasms Network Pharmacology Neurosciences Paclitaxel Paclitaxel - pharmacology Pharmacology Pharmacology/Toxicology Quercetin Quercetin - pharmacology Signal transduction
Online-Zugang:	Volltext
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