The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders
Microglia-mediated neuroinflammatory responses play a key role in perioperative neurocognitive disorders (PND). Triggering receptor expressed on myeloid cells-1 (TREM1) has been shown to be a key regulator of inflammation. However, its role in PND remains largely unknown. This study aimed to evaluat...
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| Veröffentlicht in: | Journal of neuroimmunology 2023-06, Vol.379, p.578070-578070, Article 578070 |
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| container_title | Journal of neuroimmunology |
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| creator | Tang, Chunchun Zheng, Xue Zhong, Yuanping Chen, Dongqin Zhu, Yuhang Wang, Sihui Xiong, Liulin Zhu, Zhaoqiong |
| description | Microglia-mediated neuroinflammatory responses play a key role in perioperative neurocognitive disorders (PND). Triggering receptor expressed on myeloid cells-1 (TREM1) has been shown to be a key regulator of inflammation. However, its role in PND remains largely unknown. This study aimed to evaluate the role of TREM1 in sevoflurane-induced PND. We applied AAV knockdown TREM1 in hippocampal microglia in aging mice. The mice were then subjected to neurobehavioral and biochemical testing after the intervention of sevoflurane. We found that sevoflurane inhalation can cause PND in mice, increase hippocampal TREM1 expression, polarize microglia to M1 type, upregulate TNF-α and IL-1β expression (pro-inflammatory), and inhibit TGF-β and IL-10 expression (anti-inflammatory). Knocking down TREM1 can improve sevoflurane-induced cognitive dysfunction, reduce M1 type marker iNOS, and increase M2 type marker ARG, improving the neuroinflammation. TREM1 is a target for sevoflurane-induced PND prevention.
•Sevoflurane inhalation can cause Perioperative neurocognitive disorders (PND)in mice.•Sevoflurane induced neuroinflammation and cognitive dysfunction in aging mice.•Knocking down triggering receptors expressed on myeloid cells 1 (TREM1) can improve sevoflurane-induced cognitive dysfunction.•TREM1 is a target for sevoflurane and sevoflurane-induced PND prevention. |
| doi_str_mv | 10.1016/j.jneuroim.2023.578070 |
| format | Article |
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•Sevoflurane inhalation can cause Perioperative neurocognitive disorders (PND)in mice.•Sevoflurane induced neuroinflammation and cognitive dysfunction in aging mice.•Knocking down triggering receptors expressed on myeloid cells 1 (TREM1) can improve sevoflurane-induced cognitive dysfunction.•TREM1 is a target for sevoflurane and sevoflurane-induced PND prevention.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2023.578070</identifier><identifier>PMID: 37148600</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Inflammation - metabolism ; Mice ; Microglia ; Microglia - metabolism ; Neurocognitive Disorders - metabolism ; Neuroinflammation ; Perioperative neurocognitive disorders ; Sevoflurane ; Sevoflurane - adverse effects ; Sevoflurane - metabolism ; Triggering Receptor Expressed on Myeloid Cells-1 - metabolism ; Triggering receptors expressed on myeloid cells 1</subject><ispartof>Journal of neuroimmunology, 2023-06, Vol.379, p.578070-578070, Article 578070</ispartof><rights>2023</rights><rights>Copyright © 2023. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-daff8e0809bef9ec6091daf0ed34ccad935de1d9e6a6eb6d88e38ddd574494493</citedby><cites>FETCH-LOGICAL-c368t-daff8e0809bef9ec6091daf0ed34ccad935de1d9e6a6eb6d88e38ddd574494493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2023.578070$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37148600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Chunchun</creatorcontrib><creatorcontrib>Zheng, Xue</creatorcontrib><creatorcontrib>Zhong, Yuanping</creatorcontrib><creatorcontrib>Chen, Dongqin</creatorcontrib><creatorcontrib>Zhu, Yuhang</creatorcontrib><creatorcontrib>Wang, Sihui</creatorcontrib><creatorcontrib>Xiong, Liulin</creatorcontrib><creatorcontrib>Zhu, Zhaoqiong</creatorcontrib><title>The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Microglia-mediated neuroinflammatory responses play a key role in perioperative neurocognitive disorders (PND). Triggering receptor expressed on myeloid cells-1 (TREM1) has been shown to be a key regulator of inflammation. However, its role in PND remains largely unknown. This study aimed to evaluate the role of TREM1 in sevoflurane-induced PND. We applied AAV knockdown TREM1 in hippocampal microglia in aging mice. The mice were then subjected to neurobehavioral and biochemical testing after the intervention of sevoflurane. We found that sevoflurane inhalation can cause PND in mice, increase hippocampal TREM1 expression, polarize microglia to M1 type, upregulate TNF-α and IL-1β expression (pro-inflammatory), and inhibit TGF-β and IL-10 expression (anti-inflammatory). Knocking down TREM1 can improve sevoflurane-induced cognitive dysfunction, reduce M1 type marker iNOS, and increase M2 type marker ARG, improving the neuroinflammation. TREM1 is a target for sevoflurane-induced PND prevention.
•Sevoflurane inhalation can cause Perioperative neurocognitive disorders (PND)in mice.•Sevoflurane induced neuroinflammation and cognitive dysfunction in aging mice.•Knocking down triggering receptors expressed on myeloid cells 1 (TREM1) can improve sevoflurane-induced cognitive dysfunction.•TREM1 is a target for sevoflurane and sevoflurane-induced PND prevention.</description><subject>Animals</subject><subject>Inflammation - metabolism</subject><subject>Mice</subject><subject>Microglia</subject><subject>Microglia - metabolism</subject><subject>Neurocognitive Disorders - metabolism</subject><subject>Neuroinflammation</subject><subject>Perioperative neurocognitive disorders</subject><subject>Sevoflurane</subject><subject>Sevoflurane - adverse effects</subject><subject>Sevoflurane - metabolism</subject><subject>Triggering Receptor Expressed on Myeloid Cells-1 - metabolism</subject><subject>Triggering receptors expressed on myeloid cells 1</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLwzAUgIMobk7_wsijL61Jr-mbMuYFJoLM55AlpzUjbWayDvTXm62br0JIyOE7tw-hKSUxJbS4W8frDnpndRsnJEnjvGSkJGdoTFmZRCxL6DkaBzCP8jJhI3Tl_ZoQmqdZdYlGaUkzVhAyRv3yE7CzBrCt8fJ9_kqx7rCDpjdiq7sGt1o62xgtDN5YI5z-CXHb7SkPO1ub3okOIt2pXoLCG3DahitAO8CHEaVtOn34Ku2tU-D8NbqohfFwc3wn6ONxvpw9R4u3p5fZwyKSacG2kRJ1zYAwUq2grkAWpKIhRkClmZRCVWmugKoKClHAqlCMQcqUUnmZZVU46QTdDnU3zn714Le81V6CMWFk23ueMEqqhAR3AS0GNKzrvYOab5xuhfvmlPC9cr7mJ-V8r5wPykPi9NijX7Wg_tJOjgNwPwAQNt1pcNxLDV2wpR3ILVdW_9fjF-SumgM</recordid><startdate>20230615</startdate><enddate>20230615</enddate><creator>Tang, Chunchun</creator><creator>Zheng, Xue</creator><creator>Zhong, Yuanping</creator><creator>Chen, Dongqin</creator><creator>Zhu, Yuhang</creator><creator>Wang, Sihui</creator><creator>Xiong, Liulin</creator><creator>Zhu, Zhaoqiong</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230615</creationdate><title>The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders</title><author>Tang, Chunchun ; Zheng, Xue ; Zhong, Yuanping ; Chen, Dongqin ; Zhu, Yuhang ; Wang, Sihui ; Xiong, Liulin ; Zhu, Zhaoqiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-daff8e0809bef9ec6091daf0ed34ccad935de1d9e6a6eb6d88e38ddd574494493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Inflammation - metabolism</topic><topic>Mice</topic><topic>Microglia</topic><topic>Microglia - metabolism</topic><topic>Neurocognitive Disorders - metabolism</topic><topic>Neuroinflammation</topic><topic>Perioperative neurocognitive disorders</topic><topic>Sevoflurane</topic><topic>Sevoflurane - adverse effects</topic><topic>Sevoflurane - metabolism</topic><topic>Triggering Receptor Expressed on Myeloid Cells-1 - metabolism</topic><topic>Triggering receptors expressed on myeloid cells 1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Chunchun</creatorcontrib><creatorcontrib>Zheng, Xue</creatorcontrib><creatorcontrib>Zhong, Yuanping</creatorcontrib><creatorcontrib>Chen, Dongqin</creatorcontrib><creatorcontrib>Zhu, Yuhang</creatorcontrib><creatorcontrib>Wang, Sihui</creatorcontrib><creatorcontrib>Xiong, Liulin</creatorcontrib><creatorcontrib>Zhu, Zhaoqiong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Chunchun</au><au>Zheng, Xue</au><au>Zhong, Yuanping</au><au>Chen, Dongqin</au><au>Zhu, Yuhang</au><au>Wang, Sihui</au><au>Xiong, Liulin</au><au>Zhu, Zhaoqiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2023-06-15</date><risdate>2023</risdate><volume>379</volume><spage>578070</spage><epage>578070</epage><pages>578070-578070</pages><artnum>578070</artnum><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Microglia-mediated neuroinflammatory responses play a key role in perioperative neurocognitive disorders (PND). Triggering receptor expressed on myeloid cells-1 (TREM1) has been shown to be a key regulator of inflammation. However, its role in PND remains largely unknown. This study aimed to evaluate the role of TREM1 in sevoflurane-induced PND. We applied AAV knockdown TREM1 in hippocampal microglia in aging mice. The mice were then subjected to neurobehavioral and biochemical testing after the intervention of sevoflurane. We found that sevoflurane inhalation can cause PND in mice, increase hippocampal TREM1 expression, polarize microglia to M1 type, upregulate TNF-α and IL-1β expression (pro-inflammatory), and inhibit TGF-β and IL-10 expression (anti-inflammatory). Knocking down TREM1 can improve sevoflurane-induced cognitive dysfunction, reduce M1 type marker iNOS, and increase M2 type marker ARG, improving the neuroinflammation. TREM1 is a target for sevoflurane-induced PND prevention.
•Sevoflurane inhalation can cause Perioperative neurocognitive disorders (PND)in mice.•Sevoflurane induced neuroinflammation and cognitive dysfunction in aging mice.•Knocking down triggering receptors expressed on myeloid cells 1 (TREM1) can improve sevoflurane-induced cognitive dysfunction.•TREM1 is a target for sevoflurane and sevoflurane-induced PND prevention.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37148600</pmid><doi>10.1016/j.jneuroim.2023.578070</doi><tpages>1</tpages></addata></record> |
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| subjects | Animals Inflammation - metabolism Mice Microglia Microglia - metabolism Neurocognitive Disorders - metabolism Neuroinflammation Perioperative neurocognitive disorders Sevoflurane Sevoflurane - adverse effects Sevoflurane - metabolism Triggering Receptor Expressed on Myeloid Cells-1 - metabolism Triggering receptors expressed on myeloid cells 1 |
| title | The role of TREM1 in regulating microglial polarization in sevoflurane-induced perioperative neurocognitive disorders |
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