The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast‐induced macrophage migration

Background and Purpose Low‐grade inflammation, a common feature of both diabetes and periodontitis, partly accounts for the complexity and refractoriness of diabetes‐associated periodontitis. Adiponectin (APN), the most abundant adipokine in human blood, has been widely reported to have anti‐inflamm...

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Veröffentlicht in:	British journal of pharmacology 2023-09, Vol.180 (18), p.2436-2451
Hauptverfasser:	Qiu, Wei, Wang, Zhaodan, Chen, Zehao, Sun, Qian, Wu, Hongle, Chen, Zhao, Luan, Kaiqi, Liu, Zining, Ding, Dian, Tu, Qisheng, Chen, Jake, Wu, Buling, Fang, Fuchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipo receptors AdipoAI Adiponectin Adiponectin - metabolism Agonists Alveolar bone Alveolar Bone Loss - drug therapy Alveolar Bone Loss - metabolism Alveolar Bone Loss - prevention & control Animals anti‐inflammation Bone resorption Chemokines Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism diabetes‐associated periodontitis Fibroblasts Fibroblasts - metabolism Gingiva Gum disease human gingival fibroblasts Humans Inflammation Inflammation - metabolism Insulin Insulins - metabolism Leukocyte migration Lipopolysaccharides - pharmacology Macrophages Macrophages - metabolism Monocyte chemoattractant protein 1 Monocytes NF-kappa B - metabolism Periodontitis Periodontitis - chemically induced Periodontitis - drug therapy Periodontitis - metabolism Rats Rats, Zucker Receptors, Adiponectin - metabolism Signal transduction siRNA
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