Measurement of dose enhancement factor for Xoft Axxent electronic brachytherapy device using nanoparticle-embedded alginate film and radiochromic film
Aim: Inw nanoparticles-aided radiotherapy, the radiation sensitivity of tumor is increased with the infusion of nanoparticles in tumor. This therapeutic modality is capable of delivering enhanced dose to tumor, without exceeding the normal tissue tolerance dose. Further, the quantification of the en...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2023-04, Vol.19 (8), p.0-0 |
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| container_title | Journal of cancer research and therapeutics |
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| creator | Kakade, Nitin Das, Abhishek Kumar, Rajesh Sharma, S Maiti, Nandita Chadha, Ridhima Sapra, B |
| description | Aim: Inw nanoparticles-aided radiotherapy, the radiation sensitivity of tumor is increased with the infusion of nanoparticles in tumor. This therapeutic modality is capable of delivering enhanced dose to tumor, without exceeding the normal tissue tolerance dose. Further, the quantification of the enhanced dose using suitable dosimeter is important. The present study is aimed at measuring the dose enhancement factors (DEFs) using the combination of nanoparticles-embedded alginate (Alg) film and unlaminated Gafchromic EBT3 film.
Materials and Methods: Gold nanoparticles (AuNPs)- and silver nanoparticles (AgNPs)-embedded Alg polymer films were synthesized and characterized using standard techniques. Further, a customized version of the Gafchromic EBT3 film, i.e., unlaminated EBT3 film, was specially fabricated. The DEFs were measured using Xoft Axxent electronic brachytherapy device.
Results: The surface plasmon resonance (SPR) and particle size of AuNPs were found to be 550 and 15 ± 2 nm, respectively. In the case of AgNPs, the SPR and particle size were recorded as 400 and 13 ± 2 nm, respectively. The DEFs measured, using unlaminated EBT3 film, for Xoft Axxent electronic brachytherapy using AuNPs and AgNPs were 1.35 ± 0.02 and 1.20 ± 0.01, respectively.
Conclusion: The increase in dose enhancement during nanoparticles-aided electronic brachytherapy can be attributed to dominance of photoelectric effect, due to the presence of low-energy X-rays. The investigation indicates that the Xoft Axxent electronic brachytherapy device is suitable for nanoparticles-aided brachytherapy. |
| doi_str_mv | 10.4103/jcrt.jcrt_207_21 |
| format | Article |
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Materials and Methods: Gold nanoparticles (AuNPs)- and silver nanoparticles (AgNPs)-embedded Alg polymer films were synthesized and characterized using standard techniques. Further, a customized version of the Gafchromic EBT3 film, i.e., unlaminated EBT3 film, was specially fabricated. The DEFs were measured using Xoft Axxent electronic brachytherapy device.
Results: The surface plasmon resonance (SPR) and particle size of AuNPs were found to be 550 and 15 ± 2 nm, respectively. In the case of AgNPs, the SPR and particle size were recorded as 400 and 13 ± 2 nm, respectively. The DEFs measured, using unlaminated EBT3 film, for Xoft Axxent electronic brachytherapy using AuNPs and AgNPs were 1.35 ± 0.02 and 1.20 ± 0.01, respectively.
Conclusion: The increase in dose enhancement during nanoparticles-aided electronic brachytherapy can be attributed to dominance of photoelectric effect, due to the presence of low-energy X-rays. The investigation indicates that the Xoft Axxent electronic brachytherapy device is suitable for nanoparticles-aided brachytherapy.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/jcrt.jcrt_207_21</identifier><identifier>PMID: 37147944</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Brachytherapy - methods ; Cancer ; Dose-response relationship (Biochemistry) ; Electronics ; Equipment and supplies ; Gold ; Health aspects ; Humans ; Metal Nanoparticles ; Methods ; Nanoparticles ; Oncology, Experimental ; Particle size ; Patient outcomes ; Radiation therapy ; Radioisotope brachytherapy ; Radiotherapy Dosage ; Silver</subject><ispartof>Journal of cancer research and therapeutics, 2023-04, Vol.19 (8), p.0-0</ispartof><rights>COPYRIGHT 2023 Medknow Publications and Media Pvt. Ltd.</rights><rights>2023. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c589m-b8c5adc773d0d90f83df1cfae38d67c9278b30e9c7cd731a8a7d6ea79e0373e43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27435,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37147944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kakade, Nitin</creatorcontrib><creatorcontrib>Das, Abhishek</creatorcontrib><creatorcontrib>Kumar, Rajesh</creatorcontrib><creatorcontrib>Sharma, S</creatorcontrib><creatorcontrib>Maiti, Nandita</creatorcontrib><creatorcontrib>Chadha, Ridhima</creatorcontrib><creatorcontrib>Sapra, B</creatorcontrib><title>Measurement of dose enhancement factor for Xoft Axxent electronic brachytherapy device using nanoparticle-embedded alginate film and radiochromic film</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Aim: Inw nanoparticles-aided radiotherapy, the radiation sensitivity of tumor is increased with the infusion of nanoparticles in tumor. This therapeutic modality is capable of delivering enhanced dose to tumor, without exceeding the normal tissue tolerance dose. Further, the quantification of the enhanced dose using suitable dosimeter is important. The present study is aimed at measuring the dose enhancement factors (DEFs) using the combination of nanoparticles-embedded alginate (Alg) film and unlaminated Gafchromic EBT3 film.
Materials and Methods: Gold nanoparticles (AuNPs)- and silver nanoparticles (AgNPs)-embedded Alg polymer films were synthesized and characterized using standard techniques. Further, a customized version of the Gafchromic EBT3 film, i.e., unlaminated EBT3 film, was specially fabricated. The DEFs were measured using Xoft Axxent electronic brachytherapy device.
Results: The surface plasmon resonance (SPR) and particle size of AuNPs were found to be 550 and 15 ± 2 nm, respectively. In the case of AgNPs, the SPR and particle size were recorded as 400 and 13 ± 2 nm, respectively. The DEFs measured, using unlaminated EBT3 film, for Xoft Axxent electronic brachytherapy using AuNPs and AgNPs were 1.35 ± 0.02 and 1.20 ± 0.01, respectively.
Conclusion: The increase in dose enhancement during nanoparticles-aided electronic brachytherapy can be attributed to dominance of photoelectric effect, due to the presence of low-energy X-rays. The investigation indicates that the Xoft Axxent electronic brachytherapy device is suitable for nanoparticles-aided brachytherapy.</description><subject>Brachytherapy - methods</subject><subject>Cancer</subject><subject>Dose-response relationship (Biochemistry)</subject><subject>Electronics</subject><subject>Equipment and supplies</subject><subject>Gold</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Metal Nanoparticles</subject><subject>Methods</subject><subject>Nanoparticles</subject><subject>Oncology, Experimental</subject><subject>Particle size</subject><subject>Patient outcomes</subject><subject>Radiation therapy</subject><subject>Radioisotope brachytherapy</subject><subject>Radiotherapy Dosage</subject><subject>Silver</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkl-PEyEUxSdG49bVd58MiS--TIWBLsybzcZ_yRpfNPGNULi002WgAmO3X2Q_7zJ2V6upcUOA5OZ3zyWHU1XPCZ4ygunrtY55Oh6ywVw25EE1IW0rakaoeFhNcMtpTZhoTqonKa0xnvGmEY-rE8oJ4y1jk-r6E6g0ROjBZxQsMiEBAr9SXu9rVukcIrJlfws2o_nV1VgGBzrH4DuNFlHp1S6vIKrNDhn40WlAQ-r8Ennlw0bF3GkHNfQLMAYMUm7ZeZUB2c71SHmDojJd0KsY-qI3Vp9Wj6xyCZ7d3qfV13dvv5x_qC8-v_94Pr-o9Uy0fb0QeqaM5pwabFpsBTWWaKuACnPGddtwsaAYWs214ZQoobg5A8VbwJRTYPS0erXX3cTwfYCUZd8lDc4pD2FIshEEt4RTLgr68i90HYboy-sKhVvasAbj39RSOZCdtyEXe0ZRORcNo5zN_kNxJijlMz5S9RFqCb447YKHYhT8qXof_lB_eoQvy0D5h6MD7tVwOAHvG3QMKUWwchO7XsWdJFiOCZY_w3uQ4NLy4tbmYdGD-dVwF9kCvNkD2-AyxHTphi1EWdhLH7b_FJZY3kWd3gCT8AWL</recordid><startdate>20230401</startdate><enddate>20230401</enddate><creator>Kakade, Nitin</creator><creator>Das, Abhishek</creator><creator>Kumar, Rajesh</creator><creator>Sharma, S</creator><creator>Maiti, Nandita</creator><creator>Chadha, Ridhima</creator><creator>Sapra, B</creator><general>Wolters Kluwer India Pvt. 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Sharma, S ; Maiti, Nandita ; Chadha, Ridhima ; Sapra, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589m-b8c5adc773d0d90f83df1cfae38d67c9278b30e9c7cd731a8a7d6ea79e0373e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Brachytherapy - methods</topic><topic>Cancer</topic><topic>Dose-response relationship (Biochemistry)</topic><topic>Electronics</topic><topic>Equipment and supplies</topic><topic>Gold</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Metal Nanoparticles</topic><topic>Methods</topic><topic>Nanoparticles</topic><topic>Oncology, Experimental</topic><topic>Particle size</topic><topic>Patient outcomes</topic><topic>Radiation therapy</topic><topic>Radioisotope brachytherapy</topic><topic>Radiotherapy Dosage</topic><topic>Silver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kakade, Nitin</creatorcontrib><creatorcontrib>Das, Abhishek</creatorcontrib><creatorcontrib>Kumar, Rajesh</creatorcontrib><creatorcontrib>Sharma, S</creatorcontrib><creatorcontrib>Maiti, Nandita</creatorcontrib><creatorcontrib>Chadha, Ridhima</creatorcontrib><creatorcontrib>Sapra, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kakade, Nitin</au><au>Das, Abhishek</au><au>Kumar, Rajesh</au><au>Sharma, S</au><au>Maiti, Nandita</au><au>Chadha, Ridhima</au><au>Sapra, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measurement of dose enhancement factor for Xoft Axxent electronic brachytherapy device using nanoparticle-embedded alginate film and radiochromic film</atitle><jtitle>Journal of cancer research and therapeutics</jtitle><addtitle>J Cancer Res Ther</addtitle><date>2023-04-01</date><risdate>2023</risdate><volume>19</volume><issue>8</issue><spage>0</spage><epage>0</epage><pages>0-0</pages><issn>0973-1482</issn><eissn>1998-4138</eissn><abstract>Aim: Inw nanoparticles-aided radiotherapy, the radiation sensitivity of tumor is increased with the infusion of nanoparticles in tumor. This therapeutic modality is capable of delivering enhanced dose to tumor, without exceeding the normal tissue tolerance dose. Further, the quantification of the enhanced dose using suitable dosimeter is important. The present study is aimed at measuring the dose enhancement factors (DEFs) using the combination of nanoparticles-embedded alginate (Alg) film and unlaminated Gafchromic EBT3 film.
Materials and Methods: Gold nanoparticles (AuNPs)- and silver nanoparticles (AgNPs)-embedded Alg polymer films were synthesized and characterized using standard techniques. Further, a customized version of the Gafchromic EBT3 film, i.e., unlaminated EBT3 film, was specially fabricated. The DEFs were measured using Xoft Axxent electronic brachytherapy device.
Results: The surface plasmon resonance (SPR) and particle size of AuNPs were found to be 550 and 15 ± 2 nm, respectively. In the case of AgNPs, the SPR and particle size were recorded as 400 and 13 ± 2 nm, respectively. The DEFs measured, using unlaminated EBT3 film, for Xoft Axxent electronic brachytherapy using AuNPs and AgNPs were 1.35 ± 0.02 and 1.20 ± 0.01, respectively.
Conclusion: The increase in dose enhancement during nanoparticles-aided electronic brachytherapy can be attributed to dominance of photoelectric effect, due to the presence of low-energy X-rays. The investigation indicates that the Xoft Axxent electronic brachytherapy device is suitable for nanoparticles-aided brachytherapy.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>37147944</pmid><doi>10.4103/jcrt.jcrt_207_21</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Brachytherapy - methods Cancer Dose-response relationship (Biochemistry) Electronics Equipment and supplies Gold Health aspects Humans Metal Nanoparticles Methods Nanoparticles Oncology, Experimental Particle size Patient outcomes Radiation therapy Radioisotope brachytherapy Radiotherapy Dosage Silver |
| title | Measurement of dose enhancement factor for Xoft Axxent electronic brachytherapy device using nanoparticle-embedded alginate film and radiochromic film |
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