Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study

Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival. Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with...

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Veröffentlicht in:HPB (Oxford, England) England), 2023-07, Vol.25 (7), p.788-797
Hauptverfasser: Labib, Peter L., Denson, Jemimah, Ausania, Fabio, Pando, Elizabeth, Roberts, Keith J., Kausar, Ambareen, Marangoni, Gabriele, Thomasset, Sarah C., Lykoudis, Pavlos, Maglione, Manuel, Alhaboob, Nassir, Bari, Hassaan, Smith, Andrew M., Srinivasan, Parthi, Davidson, Brian R., Croagh, Daniel, Thakkar, Rohan, Silva, Michael A., Lapolla, Pierfrancesco, Mingoli, Andrea, Porcu, Alberto, Shah, Nehal S., Hamady, Zaed Z.R., Aroori, Somaiah, Russell, Thomas B., Streeter, Adam, Puckett, Mark, Browning, Matthew G., González-Abós, Carolina, Moller, Elsa G., Taboada, Cristina D., Pande, Rupaly, Alfarah, Jameel, Bandyopadhyay, Samik, Mavroeidis, Vasileios K., Rees, Jonathan R.E., Blege, Collaborator: Harry, Thomasset, Sarah, Frampton, Adam, Blackburn, Jessie, Field, Daniel, Gouda, Mohammed, Bellotti, Ruben, Hamid, Hytham K.S., Ahmed, Hassan, Smith, Andrew, Moriarty, Catherine, White, Louise, Bode, Kerry, Sharp, Judith, Wragg, Rosie, Jackson, Beverley, Spalding, Duncan, Fehervari, Matyas, Pai, Madhava, Alghazawi, Laith, Pericleous, Stephanos, Shaw, Conrad, Morare, Nolitha, Zaban, Mohamad K., Bhogal, Ricky, Doyle, Joseph, Guerrero, Alan, Moguel, Andre, Chan, Carlos, Jones, Michael, Buckley, Edward, Akter, Nasreen, Gomez, Dhanny, Gordon, Gregory, Silva, Michael, Urbonas, Tomas, Brachini, Gioia, Chirletti, Piero, Perra, Teresa, Abd Kahar, Nurul N., Hamady, Zaed, Arshad, Ali, Al-Sarrieh, Bilal, Hammoda, Mohammed, Serrablo, Alejandro, Artigas, Maria, Paterna-López, Sandra
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container_title HPB (Oxford, England)
container_volume 25
creator Labib, Peter L.
Denson, Jemimah
Ausania, Fabio
Pando, Elizabeth
Roberts, Keith J.
Kausar, Ambareen
Marangoni, Gabriele
Thomasset, Sarah C.
Lykoudis, Pavlos
Maglione, Manuel
Alhaboob, Nassir
Bari, Hassaan
Smith, Andrew M.
Srinivasan, Parthi
Davidson, Brian R.
Croagh, Daniel
Thakkar, Rohan
Silva, Michael A.
Lapolla, Pierfrancesco
Mingoli, Andrea
Porcu, Alberto
Shah, Nehal S.
Hamady, Zaed Z.R.
Aroori, Somaiah
Aroori, Somaiah
Labib, Peter L.
Russell, Thomas B.
Streeter, Adam
Denson, Jemimah
Puckett, Mark
Browning, Matthew G.
Ausania, Fabio
González-Abós, Carolina
Moller, Elsa G.
Taboada, Cristina D.
Roberts, Keith J.
Pande, Rupaly
Alfarah, Jameel
Kausar, Ambareen
Bandyopadhyay, Samik
Mavroeidis, Vasileios K.
Rees, Jonathan R.E.
Marangoni, Gabriele
Blege, Collaborator: Harry
Thomasset, Sarah
Frampton, Adam
Blackburn, Jessie
Lykoudis, Pavlos
Field, Daniel
Gouda, Mohammed
Bellotti, Ruben
Alhaboob, Nassir
Hamid, Hytham K.S.
Bari, Hassaan
Ahmed, Hassan
Smith, Andrew
Moriarty, Catherine
White, Louise
Bode, Kerry
Sharp, Judith
Wragg, Rosie
Jackson, Beverley
Spalding, Duncan
Fehervari, Matyas
Pai, Madhava
Alghazawi, Laith
Pericleous, Stephanos
Shaw, Conrad
Morare, Nolitha
Zaban, Mohamad K.
Bhogal, Ricky
Doyle, Joseph
Mavroeidis, Vasileios K.
Croagh, Daniel
Guerrero, Alan
Moguel, Andre
Chan, Carlos
Thakkar, Rohan
Jones, Michael
Buckley, Edward
Akter, Nasreen
Gomez, Dhanny
Gordon, Gregory
Silva, Michael
Urbonas, Tomas
Lapolla, Pierfrancesco
Mingoli, Andrea
Brachini, Gioia
Chirletti, Piero
Porcu, Alberto
Perra, Teresa
Shah, Nehal S.
Abd Kahar, Nurul N.
Hamady, Zaed
Arshad, Ali
Al-Sarrieh, Bilal
Hammoda, Mohammed
Serrablo, Alejandro
Artigas, Maria
Paterna-López, Sandra
description Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival. Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not. 394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage > II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence. This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.
doi_str_mv 10.1016/j.hpb.2023.03.010
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Denson, Jemimah ; Ausania, Fabio ; Pando, Elizabeth ; Roberts, Keith J. ; Kausar, Ambareen ; Marangoni, Gabriele ; Thomasset, Sarah C. ; Lykoudis, Pavlos ; Maglione, Manuel ; Alhaboob, Nassir ; Bari, Hassaan ; Smith, Andrew M. ; Srinivasan, Parthi ; Davidson, Brian R. ; Croagh, Daniel ; Thakkar, Rohan ; Silva, Michael A. ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Porcu, Alberto ; Shah, Nehal S. ; Hamady, Zaed Z.R. ; Aroori, Somaiah ; Aroori, Somaiah ; Labib, Peter L. ; Russell, Thomas B. ; Streeter, Adam ; Denson, Jemimah ; Puckett, Mark ; Browning, Matthew G. ; Ausania, Fabio ; González-Abós, Carolina ; Moller, Elsa G. ; Taboada, Cristina D. ; Roberts, Keith J. ; Pande, Rupaly ; Alfarah, Jameel ; Kausar, Ambareen ; Bandyopadhyay, Samik ; Mavroeidis, Vasileios K. ; Rees, Jonathan R.E. ; Marangoni, Gabriele ; Blege, Collaborator: Harry ; Thomasset, Sarah ; Frampton, Adam ; Blackburn, Jessie ; Lykoudis, Pavlos ; Field, Daniel ; Gouda, Mohammed ; Bellotti, Ruben ; Alhaboob, Nassir ; Hamid, Hytham K.S. ; Bari, Hassaan ; Ahmed, Hassan ; Smith, Andrew ; Moriarty, Catherine ; White, Louise ; Bode, Kerry ; Sharp, Judith ; Wragg, Rosie ; Jackson, Beverley ; Spalding, Duncan ; Fehervari, Matyas ; Pai, Madhava ; Alghazawi, Laith ; Pericleous, Stephanos ; Shaw, Conrad ; Morare, Nolitha ; Zaban, Mohamad K. ; Bhogal, Ricky ; Doyle, Joseph ; Mavroeidis, Vasileios K. ; Croagh, Daniel ; Guerrero, Alan ; Moguel, Andre ; Chan, Carlos ; Thakkar, Rohan ; Jones, Michael ; Buckley, Edward ; Akter, Nasreen ; Gomez, Dhanny ; Gordon, Gregory ; Silva, Michael ; Urbonas, Tomas ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Chirletti, Piero ; Porcu, Alberto ; Perra, Teresa ; Shah, Nehal S. ; Abd Kahar, Nurul N. ; Hamady, Zaed ; Arshad, Ali ; Al-Sarrieh, Bilal ; Hammoda, Mohammed ; Serrablo, Alejandro ; Artigas, Maria ; Paterna-López, Sandra</creator><creatorcontrib>Labib, Peter L. ; Denson, Jemimah ; Ausania, Fabio ; Pando, Elizabeth ; Roberts, Keith J. ; Kausar, Ambareen ; Marangoni, Gabriele ; Thomasset, Sarah C. ; Lykoudis, Pavlos ; Maglione, Manuel ; Alhaboob, Nassir ; Bari, Hassaan ; Smith, Andrew M. ; Srinivasan, Parthi ; Davidson, Brian R. ; Croagh, Daniel ; Thakkar, Rohan ; Silva, Michael A. ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Porcu, Alberto ; Shah, Nehal S. ; Hamady, Zaed Z.R. ; Aroori, Somaiah ; Aroori, Somaiah ; Labib, Peter L. ; Russell, Thomas B. ; Streeter, Adam ; Denson, Jemimah ; Puckett, Mark ; Browning, Matthew G. ; Ausania, Fabio ; González-Abós, Carolina ; Moller, Elsa G. ; Taboada, Cristina D. ; Roberts, Keith J. ; Pande, Rupaly ; Alfarah, Jameel ; Kausar, Ambareen ; Bandyopadhyay, Samik ; Mavroeidis, Vasileios K. ; Rees, Jonathan R.E. ; Marangoni, Gabriele ; Blege, Collaborator: Harry ; Thomasset, Sarah ; Frampton, Adam ; Blackburn, Jessie ; Lykoudis, Pavlos ; Field, Daniel ; Gouda, Mohammed ; Bellotti, Ruben ; Alhaboob, Nassir ; Hamid, Hytham K.S. ; Bari, Hassaan ; Ahmed, Hassan ; Smith, Andrew ; Moriarty, Catherine ; White, Louise ; Bode, Kerry ; Sharp, Judith ; Wragg, Rosie ; Jackson, Beverley ; Spalding, Duncan ; Fehervari, Matyas ; Pai, Madhava ; Alghazawi, Laith ; Pericleous, Stephanos ; Shaw, Conrad ; Morare, Nolitha ; Zaban, Mohamad K. ; Bhogal, Ricky ; Doyle, Joseph ; Mavroeidis, Vasileios K. ; Croagh, Daniel ; Guerrero, Alan ; Moguel, Andre ; Chan, Carlos ; Thakkar, Rohan ; Jones, Michael ; Buckley, Edward ; Akter, Nasreen ; Gomez, Dhanny ; Gordon, Gregory ; Silva, Michael ; Urbonas, Tomas ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Chirletti, Piero ; Porcu, Alberto ; Perra, Teresa ; Shah, Nehal S. ; Abd Kahar, Nurul N. ; Hamady, Zaed ; Arshad, Ali ; Al-Sarrieh, Bilal ; Hammoda, Mohammed ; Serrablo, Alejandro ; Artigas, Maria ; Paterna-López, Sandra ; RAW Study Collaborators</creatorcontrib><description>Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival. Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not. 394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage &gt; II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence. This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.</description><identifier>ISSN: 1365-182X</identifier><identifier>ISSN: 1477-2574</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1016/j.hpb.2023.03.010</identifier><identifier>PMID: 37149485</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenocarcinoma ; Ampulla of Vater - pathology ; Ampulla of Vater - surgery ; Common Bile Duct Neoplasms ; Duodenal Neoplasms - pathology ; Humans ; Neoplasm Recurrence, Local - pathology ; Pancreatic Neoplasms ; Pancreaticoduodenectomy - adverse effects ; Retrospective Studies</subject><ispartof>HPB (Oxford, England), 2023-07, Vol.25 (7), p.788-797</ispartof><rights>2023 International Hepato-Pancreato-Biliary Association Inc.</rights><rights>Copyright © 2023 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. 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Michael</creatorcontrib><creatorcontrib>Buckley, Edward</creatorcontrib><creatorcontrib>Akter, Nasreen</creatorcontrib><creatorcontrib>Gomez, Dhanny</creatorcontrib><creatorcontrib>Gordon, Gregory</creatorcontrib><creatorcontrib>Silva, Michael</creatorcontrib><creatorcontrib>Urbonas, Tomas</creatorcontrib><creatorcontrib>Lapolla, Pierfrancesco</creatorcontrib><creatorcontrib>Mingoli, Andrea</creatorcontrib><creatorcontrib>Brachini, Gioia</creatorcontrib><creatorcontrib>Chirletti, Piero</creatorcontrib><creatorcontrib>Porcu, Alberto</creatorcontrib><creatorcontrib>Perra, Teresa</creatorcontrib><creatorcontrib>Shah, Nehal S.</creatorcontrib><creatorcontrib>Abd Kahar, Nurul N.</creatorcontrib><creatorcontrib>Hamady, Zaed</creatorcontrib><creatorcontrib>Arshad, Ali</creatorcontrib><creatorcontrib>Al-Sarrieh, Bilal</creatorcontrib><creatorcontrib>Hammoda, Mohammed</creatorcontrib><creatorcontrib>Serrablo, Alejandro</creatorcontrib><creatorcontrib>Artigas, Maria</creatorcontrib><creatorcontrib>Paterna-López, Sandra</creatorcontrib><creatorcontrib>RAW Study Collaborators</creatorcontrib><title>Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival. Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not. 394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage &gt; II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence. This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.</description><subject>Adenocarcinoma</subject><subject>Ampulla of Vater - pathology</subject><subject>Ampulla of Vater - surgery</subject><subject>Common Bile Duct Neoplasms</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Humans</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreaticoduodenectomy - adverse effects</subject><subject>Retrospective 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Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3004-1335</orcidid><orcidid>https://orcid.org/0000-0001-8891-2546</orcidid><orcidid>https://orcid.org/0000-0002-2720-6469</orcidid><orcidid>https://orcid.org/0000-0001-5437-9085</orcidid><orcidid>https://orcid.org/0000-0003-1479-6129</orcidid><orcidid>https://orcid.org/0000-0003-2362-9218</orcidid><orcidid>https://orcid.org/0000-0002-2236-4951</orcidid><orcidid>https://orcid.org/0000-0002-5613-6463</orcidid><orcidid>https://orcid.org/0000-0002-8188-3575</orcidid><orcidid>https://orcid.org/0000-0002-5974-187X</orcidid><orcidid>https://orcid.org/0000-0002-9762-3612</orcidid><orcidid>https://orcid.org/0000-0002-1392-2755</orcidid><orcidid>https://orcid.org/0000-0001-6836-3746</orcidid></search><sort><creationdate>202307</creationdate><title>Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study</title><author>Labib, Peter L. ; Denson, Jemimah ; Ausania, Fabio ; Pando, Elizabeth ; Roberts, Keith J. ; Kausar, Ambareen ; Marangoni, Gabriele ; Thomasset, Sarah C. ; Lykoudis, Pavlos ; Maglione, Manuel ; Alhaboob, Nassir ; Bari, Hassaan ; Smith, Andrew M. ; Srinivasan, Parthi ; Davidson, Brian R. ; Croagh, Daniel ; Thakkar, Rohan ; Silva, Michael A. ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Porcu, Alberto ; Shah, Nehal S. ; Hamady, Zaed Z.R. ; Aroori, Somaiah ; Aroori, Somaiah ; Labib, Peter L. ; Russell, Thomas B. ; Streeter, Adam ; Denson, Jemimah ; Puckett, Mark ; Browning, Matthew G. ; Ausania, Fabio ; González-Abós, Carolina ; Moller, Elsa G. ; Taboada, Cristina D. ; Roberts, Keith J. ; Pande, Rupaly ; Alfarah, Jameel ; Kausar, Ambareen ; Bandyopadhyay, Samik ; Mavroeidis, Vasileios K. ; Rees, Jonathan R.E. ; Marangoni, Gabriele ; Blege, Collaborator: Harry ; Thomasset, Sarah ; Frampton, Adam ; Blackburn, Jessie ; Lykoudis, Pavlos ; Field, Daniel ; Gouda, Mohammed ; Bellotti, Ruben ; Alhaboob, Nassir ; Hamid, Hytham K.S. ; Bari, Hassaan ; Ahmed, Hassan ; Smith, Andrew ; Moriarty, Catherine ; White, Louise ; Bode, Kerry ; Sharp, Judith ; Wragg, Rosie ; Jackson, Beverley ; Spalding, Duncan ; Fehervari, Matyas ; Pai, Madhava ; Alghazawi, Laith ; Pericleous, Stephanos ; Shaw, Conrad ; Morare, Nolitha ; Zaban, Mohamad K. ; Bhogal, Ricky ; Doyle, Joseph ; Mavroeidis, Vasileios K. ; Croagh, Daniel ; Guerrero, Alan ; Moguel, Andre ; Chan, Carlos ; Thakkar, Rohan ; Jones, Michael ; Buckley, Edward ; Akter, Nasreen ; Gomez, Dhanny ; Gordon, Gregory ; Silva, Michael ; Urbonas, Tomas ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Chirletti, Piero ; Porcu, Alberto ; Perra, Teresa ; Shah, Nehal S. ; Abd Kahar, Nurul N. ; Hamady, Zaed ; Arshad, Ali ; Al-Sarrieh, Bilal ; Hammoda, Mohammed ; Serrablo, Alejandro ; Artigas, Maria ; Paterna-López, Sandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-45872fdac12c86b3d5dea45a34c6cd51ce4be7ab54925c63b1b0da82d209bfef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenocarcinoma</topic><topic>Ampulla of Vater - pathology</topic><topic>Ampulla of Vater - surgery</topic><topic>Common Bile Duct Neoplasms</topic><topic>Duodenal Neoplasms - pathology</topic><topic>Humans</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreaticoduodenectomy - adverse effects</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labib, Peter L.</creatorcontrib><creatorcontrib>Denson, Jemimah</creatorcontrib><creatorcontrib>Ausania, Fabio</creatorcontrib><creatorcontrib>Pando, 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(Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>HPB (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labib, Peter L.</au><au>Denson, Jemimah</au><au>Ausania, Fabio</au><au>Pando, Elizabeth</au><au>Roberts, Keith J.</au><au>Kausar, Ambareen</au><au>Marangoni, Gabriele</au><au>Thomasset, Sarah C.</au><au>Lykoudis, Pavlos</au><au>Maglione, Manuel</au><au>Alhaboob, Nassir</au><au>Bari, Hassaan</au><au>Smith, Andrew M.</au><au>Srinivasan, Parthi</au><au>Davidson, Brian R.</au><au>Croagh, Daniel</au><au>Thakkar, Rohan</au><au>Silva, Michael A.</au><au>Lapolla, Pierfrancesco</au><au>Mingoli, Andrea</au><au>Porcu, Alberto</au><au>Shah, Nehal S.</au><au>Hamady, Zaed Z.R.</au><au>Aroori, Somaiah</au><au>Aroori, Somaiah</au><au>Labib, Peter L.</au><au>Russell, Thomas B.</au><au>Streeter, Adam</au><au>Denson, Jemimah</au><au>Puckett, Mark</au><au>Browning, Matthew G.</au><au>Ausania, Fabio</au><au>González-Abós, Carolina</au><au>Moller, Elsa G.</au><au>Taboada, Cristina D.</au><au>Roberts, Keith J.</au><au>Pande, Rupaly</au><au>Alfarah, Jameel</au><au>Kausar, Ambareen</au><au>Bandyopadhyay, Samik</au><au>Mavroeidis, Vasileios K.</au><au>Rees, Jonathan R.E.</au><au>Marangoni, Gabriele</au><au>Blege, Collaborator: Harry</au><au>Thomasset, Sarah</au><au>Frampton, Adam</au><au>Blackburn, Jessie</au><au>Lykoudis, Pavlos</au><au>Field, Daniel</au><au>Gouda, Mohammed</au><au>Bellotti, Ruben</au><au>Alhaboob, Nassir</au><au>Hamid, Hytham K.S.</au><au>Bari, Hassaan</au><au>Ahmed, Hassan</au><au>Smith, Andrew</au><au>Moriarty, Catherine</au><au>White, Louise</au><au>Bode, Kerry</au><au>Sharp, Judith</au><au>Wragg, Rosie</au><au>Jackson, Beverley</au><au>Spalding, Duncan</au><au>Fehervari, Matyas</au><au>Pai, Madhava</au><au>Alghazawi, Laith</au><au>Pericleous, Stephanos</au><au>Shaw, Conrad</au><au>Morare, Nolitha</au><au>Zaban, Mohamad K.</au><au>Bhogal, Ricky</au><au>Doyle, Joseph</au><au>Mavroeidis, Vasileios K.</au><au>Croagh, Daniel</au><au>Guerrero, Alan</au><au>Moguel, Andre</au><au>Chan, Carlos</au><au>Thakkar, Rohan</au><au>Jones, Michael</au><au>Buckley, Edward</au><au>Akter, Nasreen</au><au>Gomez, Dhanny</au><au>Gordon, Gregory</au><au>Silva, Michael</au><au>Urbonas, Tomas</au><au>Lapolla, Pierfrancesco</au><au>Mingoli, Andrea</au><au>Brachini, Gioia</au><au>Chirletti, Piero</au><au>Porcu, Alberto</au><au>Perra, Teresa</au><au>Shah, Nehal S.</au><au>Abd Kahar, Nurul N.</au><au>Hamady, Zaed</au><au>Arshad, Ali</au><au>Al-Sarrieh, Bilal</au><au>Hammoda, Mohammed</au><au>Serrablo, Alejandro</au><au>Artigas, Maria</au><au>Paterna-López, Sandra</au><aucorp>RAW Study Collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study</atitle><jtitle>HPB (Oxford, England)</jtitle><addtitle>HPB (Oxford)</addtitle><date>2023-07</date><risdate>2023</risdate><volume>25</volume><issue>7</issue><spage>788</spage><epage>797</epage><pages>788-797</pages><issn>1365-182X</issn><issn>1477-2574</issn><eissn>1477-2574</eissn><abstract>Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival. Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not. 394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage &gt; II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence. This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37149485</pmid><doi>10.1016/j.hpb.2023.03.010</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3004-1335</orcidid><orcidid>https://orcid.org/0000-0001-8891-2546</orcidid><orcidid>https://orcid.org/0000-0002-2720-6469</orcidid><orcidid>https://orcid.org/0000-0001-5437-9085</orcidid><orcidid>https://orcid.org/0000-0003-1479-6129</orcidid><orcidid>https://orcid.org/0000-0003-2362-9218</orcidid><orcidid>https://orcid.org/0000-0002-2236-4951</orcidid><orcidid>https://orcid.org/0000-0002-5613-6463</orcidid><orcidid>https://orcid.org/0000-0002-8188-3575</orcidid><orcidid>https://orcid.org/0000-0002-5974-187X</orcidid><orcidid>https://orcid.org/0000-0002-9762-3612</orcidid><orcidid>https://orcid.org/0000-0002-1392-2755</orcidid><orcidid>https://orcid.org/0000-0001-6836-3746</orcidid><oa>free_for_read</oa></addata></record>
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subjects Adenocarcinoma
Ampulla of Vater - pathology
Ampulla of Vater - surgery
Common Bile Duct Neoplasms
Duodenal Neoplasms - pathology
Humans
Neoplasm Recurrence, Local - pathology
Pancreatic Neoplasms
Pancreaticoduodenectomy - adverse effects
Retrospective Studies
title Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study
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