Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study
Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival. Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with...
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creator | Labib, Peter L. Denson, Jemimah Ausania, Fabio Pando, Elizabeth Roberts, Keith J. Kausar, Ambareen Marangoni, Gabriele Thomasset, Sarah C. Lykoudis, Pavlos Maglione, Manuel Alhaboob, Nassir Bari, Hassaan Smith, Andrew M. Srinivasan, Parthi Davidson, Brian R. Croagh, Daniel Thakkar, Rohan Silva, Michael A. Lapolla, Pierfrancesco Mingoli, Andrea Porcu, Alberto Shah, Nehal S. Hamady, Zaed Z.R. Aroori, Somaiah Aroori, Somaiah Labib, Peter L. Russell, Thomas B. Streeter, Adam Denson, Jemimah Puckett, Mark Browning, Matthew G. Ausania, Fabio González-Abós, Carolina Moller, Elsa G. Taboada, Cristina D. Roberts, Keith J. Pande, Rupaly Alfarah, Jameel Kausar, Ambareen Bandyopadhyay, Samik Mavroeidis, Vasileios K. Rees, Jonathan R.E. Marangoni, Gabriele Blege, Collaborator: Harry Thomasset, Sarah Frampton, Adam Blackburn, Jessie Lykoudis, Pavlos Field, Daniel Gouda, Mohammed Bellotti, Ruben Alhaboob, Nassir Hamid, Hytham K.S. Bari, Hassaan Ahmed, Hassan Smith, Andrew Moriarty, Catherine White, Louise Bode, Kerry Sharp, Judith Wragg, Rosie Jackson, Beverley Spalding, Duncan Fehervari, Matyas Pai, Madhava Alghazawi, Laith Pericleous, Stephanos Shaw, Conrad Morare, Nolitha Zaban, Mohamad K. Bhogal, Ricky Doyle, Joseph Mavroeidis, Vasileios K. Croagh, Daniel Guerrero, Alan Moguel, Andre Chan, Carlos Thakkar, Rohan Jones, Michael Buckley, Edward Akter, Nasreen Gomez, Dhanny Gordon, Gregory Silva, Michael Urbonas, Tomas Lapolla, Pierfrancesco Mingoli, Andrea Brachini, Gioia Chirletti, Piero Porcu, Alberto Perra, Teresa Shah, Nehal S. Abd Kahar, Nurul N. Hamady, Zaed Arshad, Ali Al-Sarrieh, Bilal Hammoda, Mohammed Serrablo, Alejandro Artigas, Maria Paterna-López, Sandra |
description | Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival.
Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not.
394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage > II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence.
This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy. |
doi_str_mv | 10.1016/j.hpb.2023.03.010 |
format | Article |
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Denson, Jemimah ; Ausania, Fabio ; Pando, Elizabeth ; Roberts, Keith J. ; Kausar, Ambareen ; Marangoni, Gabriele ; Thomasset, Sarah C. ; Lykoudis, Pavlos ; Maglione, Manuel ; Alhaboob, Nassir ; Bari, Hassaan ; Smith, Andrew M. ; Srinivasan, Parthi ; Davidson, Brian R. ; Croagh, Daniel ; Thakkar, Rohan ; Silva, Michael A. ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Porcu, Alberto ; Shah, Nehal S. ; Hamady, Zaed Z.R. ; Aroori, Somaiah ; Aroori, Somaiah ; Labib, Peter L. ; Russell, Thomas B. ; Streeter, Adam ; Denson, Jemimah ; Puckett, Mark ; Browning, Matthew G. ; Ausania, Fabio ; González-Abós, Carolina ; Moller, Elsa G. ; Taboada, Cristina D. ; Roberts, Keith J. ; Pande, Rupaly ; Alfarah, Jameel ; Kausar, Ambareen ; Bandyopadhyay, Samik ; Mavroeidis, Vasileios K. ; Rees, Jonathan R.E. ; Marangoni, Gabriele ; Blege, Collaborator: Harry ; Thomasset, Sarah ; Frampton, Adam ; Blackburn, Jessie ; Lykoudis, Pavlos ; Field, Daniel ; Gouda, Mohammed ; Bellotti, Ruben ; Alhaboob, Nassir ; Hamid, Hytham K.S. ; Bari, Hassaan ; Ahmed, Hassan ; Smith, Andrew ; Moriarty, Catherine ; White, Louise ; Bode, Kerry ; Sharp, Judith ; Wragg, Rosie ; Jackson, Beverley ; Spalding, Duncan ; Fehervari, Matyas ; Pai, Madhava ; Alghazawi, Laith ; Pericleous, Stephanos ; Shaw, Conrad ; Morare, Nolitha ; Zaban, Mohamad K. ; Bhogal, Ricky ; Doyle, Joseph ; Mavroeidis, Vasileios K. ; Croagh, Daniel ; Guerrero, Alan ; Moguel, Andre ; Chan, Carlos ; Thakkar, Rohan ; Jones, Michael ; Buckley, Edward ; Akter, Nasreen ; Gomez, Dhanny ; Gordon, Gregory ; Silva, Michael ; Urbonas, Tomas ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Chirletti, Piero ; Porcu, Alberto ; Perra, Teresa ; Shah, Nehal S. ; Abd Kahar, Nurul N. ; Hamady, Zaed ; Arshad, Ali ; Al-Sarrieh, Bilal ; Hammoda, Mohammed ; Serrablo, Alejandro ; Artigas, Maria ; Paterna-López, Sandra</creator><creatorcontrib>Labib, Peter L. ; Denson, Jemimah ; Ausania, Fabio ; Pando, Elizabeth ; Roberts, Keith J. ; Kausar, Ambareen ; Marangoni, Gabriele ; Thomasset, Sarah C. ; Lykoudis, Pavlos ; Maglione, Manuel ; Alhaboob, Nassir ; Bari, Hassaan ; Smith, Andrew M. ; Srinivasan, Parthi ; Davidson, Brian R. ; Croagh, Daniel ; Thakkar, Rohan ; Silva, Michael A. ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Porcu, Alberto ; Shah, Nehal S. ; Hamady, Zaed Z.R. ; Aroori, Somaiah ; Aroori, Somaiah ; Labib, Peter L. ; Russell, Thomas B. ; Streeter, Adam ; Denson, Jemimah ; Puckett, Mark ; Browning, Matthew G. ; Ausania, Fabio ; González-Abós, Carolina ; Moller, Elsa G. ; Taboada, Cristina D. ; Roberts, Keith J. ; Pande, Rupaly ; Alfarah, Jameel ; Kausar, Ambareen ; Bandyopadhyay, Samik ; Mavroeidis, Vasileios K. ; Rees, Jonathan R.E. ; Marangoni, Gabriele ; Blege, Collaborator: Harry ; Thomasset, Sarah ; Frampton, Adam ; Blackburn, Jessie ; Lykoudis, Pavlos ; Field, Daniel ; Gouda, Mohammed ; Bellotti, Ruben ; Alhaboob, Nassir ; Hamid, Hytham K.S. ; Bari, Hassaan ; Ahmed, Hassan ; Smith, Andrew ; Moriarty, Catherine ; White, Louise ; Bode, Kerry ; Sharp, Judith ; Wragg, Rosie ; Jackson, Beverley ; Spalding, Duncan ; Fehervari, Matyas ; Pai, Madhava ; Alghazawi, Laith ; Pericleous, Stephanos ; Shaw, Conrad ; Morare, Nolitha ; Zaban, Mohamad K. ; Bhogal, Ricky ; Doyle, Joseph ; Mavroeidis, Vasileios K. ; Croagh, Daniel ; Guerrero, Alan ; Moguel, Andre ; Chan, Carlos ; Thakkar, Rohan ; Jones, Michael ; Buckley, Edward ; Akter, Nasreen ; Gomez, Dhanny ; Gordon, Gregory ; Silva, Michael ; Urbonas, Tomas ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Chirletti, Piero ; Porcu, Alberto ; Perra, Teresa ; Shah, Nehal S. ; Abd Kahar, Nurul N. ; Hamady, Zaed ; Arshad, Ali ; Al-Sarrieh, Bilal ; Hammoda, Mohammed ; Serrablo, Alejandro ; Artigas, Maria ; Paterna-López, Sandra ; RAW Study Collaborators</creatorcontrib><description>Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival.
Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not.
394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage > II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence.
This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.</description><identifier>ISSN: 1365-182X</identifier><identifier>ISSN: 1477-2574</identifier><identifier>EISSN: 1477-2574</identifier><identifier>DOI: 10.1016/j.hpb.2023.03.010</identifier><identifier>PMID: 37149485</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenocarcinoma ; Ampulla of Vater - pathology ; Ampulla of Vater - surgery ; Common Bile Duct Neoplasms ; Duodenal Neoplasms - pathology ; Humans ; Neoplasm Recurrence, Local - pathology ; Pancreatic Neoplasms ; Pancreaticoduodenectomy - adverse effects ; Retrospective Studies</subject><ispartof>HPB (Oxford, England), 2023-07, Vol.25 (7), p.788-797</ispartof><rights>2023 International Hepato-Pancreato-Biliary Association Inc.</rights><rights>Copyright © 2023 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. 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Michael</creatorcontrib><creatorcontrib>Buckley, Edward</creatorcontrib><creatorcontrib>Akter, Nasreen</creatorcontrib><creatorcontrib>Gomez, Dhanny</creatorcontrib><creatorcontrib>Gordon, Gregory</creatorcontrib><creatorcontrib>Silva, Michael</creatorcontrib><creatorcontrib>Urbonas, Tomas</creatorcontrib><creatorcontrib>Lapolla, Pierfrancesco</creatorcontrib><creatorcontrib>Mingoli, Andrea</creatorcontrib><creatorcontrib>Brachini, Gioia</creatorcontrib><creatorcontrib>Chirletti, Piero</creatorcontrib><creatorcontrib>Porcu, Alberto</creatorcontrib><creatorcontrib>Perra, Teresa</creatorcontrib><creatorcontrib>Shah, Nehal S.</creatorcontrib><creatorcontrib>Abd Kahar, Nurul N.</creatorcontrib><creatorcontrib>Hamady, Zaed</creatorcontrib><creatorcontrib>Arshad, Ali</creatorcontrib><creatorcontrib>Al-Sarrieh, Bilal</creatorcontrib><creatorcontrib>Hammoda, Mohammed</creatorcontrib><creatorcontrib>Serrablo, Alejandro</creatorcontrib><creatorcontrib>Artigas, Maria</creatorcontrib><creatorcontrib>Paterna-López, Sandra</creatorcontrib><creatorcontrib>RAW Study Collaborators</creatorcontrib><title>Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study</title><title>HPB (Oxford, England)</title><addtitle>HPB (Oxford)</addtitle><description>Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival.
Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not.
394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage > II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence.
This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.</description><subject>Adenocarcinoma</subject><subject>Ampulla of Vater - pathology</subject><subject>Ampulla of Vater - surgery</subject><subject>Common Bile Duct Neoplasms</subject><subject>Duodenal Neoplasms - pathology</subject><subject>Humans</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Pancreatic Neoplasms</subject><subject>Pancreaticoduodenectomy - adverse effects</subject><subject>Retrospective 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Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3004-1335</orcidid><orcidid>https://orcid.org/0000-0001-8891-2546</orcidid><orcidid>https://orcid.org/0000-0002-2720-6469</orcidid><orcidid>https://orcid.org/0000-0001-5437-9085</orcidid><orcidid>https://orcid.org/0000-0003-1479-6129</orcidid><orcidid>https://orcid.org/0000-0003-2362-9218</orcidid><orcidid>https://orcid.org/0000-0002-2236-4951</orcidid><orcidid>https://orcid.org/0000-0002-5613-6463</orcidid><orcidid>https://orcid.org/0000-0002-8188-3575</orcidid><orcidid>https://orcid.org/0000-0002-5974-187X</orcidid><orcidid>https://orcid.org/0000-0002-9762-3612</orcidid><orcidid>https://orcid.org/0000-0002-1392-2755</orcidid><orcidid>https://orcid.org/0000-0001-6836-3746</orcidid></search><sort><creationdate>202307</creationdate><title>Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study</title><author>Labib, Peter L. ; Denson, Jemimah ; Ausania, Fabio ; Pando, Elizabeth ; Roberts, Keith J. ; Kausar, Ambareen ; Marangoni, Gabriele ; Thomasset, Sarah C. ; Lykoudis, Pavlos ; Maglione, Manuel ; Alhaboob, Nassir ; Bari, Hassaan ; Smith, Andrew M. ; Srinivasan, Parthi ; Davidson, Brian R. ; Croagh, Daniel ; Thakkar, Rohan ; Silva, Michael A. ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Porcu, Alberto ; Shah, Nehal S. ; Hamady, Zaed Z.R. ; Aroori, Somaiah ; Aroori, Somaiah ; Labib, Peter L. ; Russell, Thomas B. ; Streeter, Adam ; Denson, Jemimah ; Puckett, Mark ; Browning, Matthew G. ; Ausania, Fabio ; González-Abós, Carolina ; Moller, Elsa G. ; Taboada, Cristina D. ; Roberts, Keith J. ; Pande, Rupaly ; Alfarah, Jameel ; Kausar, Ambareen ; Bandyopadhyay, Samik ; Mavroeidis, Vasileios K. ; Rees, Jonathan R.E. ; Marangoni, Gabriele ; Blege, Collaborator: Harry ; Thomasset, Sarah ; Frampton, Adam ; Blackburn, Jessie ; Lykoudis, Pavlos ; Field, Daniel ; Gouda, Mohammed ; Bellotti, Ruben ; Alhaboob, Nassir ; Hamid, Hytham K.S. ; Bari, Hassaan ; Ahmed, Hassan ; Smith, Andrew ; Moriarty, Catherine ; White, Louise ; Bode, Kerry ; Sharp, Judith ; Wragg, Rosie ; Jackson, Beverley ; Spalding, Duncan ; Fehervari, Matyas ; Pai, Madhava ; Alghazawi, Laith ; Pericleous, Stephanos ; Shaw, Conrad ; Morare, Nolitha ; Zaban, Mohamad K. ; Bhogal, Ricky ; Doyle, Joseph ; Mavroeidis, Vasileios K. ; Croagh, Daniel ; Guerrero, Alan ; Moguel, Andre ; Chan, Carlos ; Thakkar, Rohan ; Jones, Michael ; Buckley, Edward ; Akter, Nasreen ; Gomez, Dhanny ; Gordon, Gregory ; Silva, Michael ; Urbonas, Tomas ; Lapolla, Pierfrancesco ; Mingoli, Andrea ; Brachini, Gioia ; Chirletti, Piero ; Porcu, Alberto ; Perra, Teresa ; Shah, Nehal S. ; Abd Kahar, Nurul N. ; Hamady, Zaed ; Arshad, Ali ; Al-Sarrieh, Bilal ; Hammoda, Mohammed ; Serrablo, Alejandro ; Artigas, Maria ; Paterna-López, Sandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-45872fdac12c86b3d5dea45a34c6cd51ce4be7ab54925c63b1b0da82d209bfef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenocarcinoma</topic><topic>Ampulla of Vater - pathology</topic><topic>Ampulla of Vater - surgery</topic><topic>Common Bile Duct Neoplasms</topic><topic>Duodenal Neoplasms - pathology</topic><topic>Humans</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Pancreatic Neoplasms</topic><topic>Pancreaticoduodenectomy - adverse effects</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Labib, Peter L.</creatorcontrib><creatorcontrib>Denson, Jemimah</creatorcontrib><creatorcontrib>Ausania, Fabio</creatorcontrib><creatorcontrib>Pando, Elizabeth</creatorcontrib><creatorcontrib>Roberts, Keith J.</creatorcontrib><creatorcontrib>Kausar, Ambareen</creatorcontrib><creatorcontrib>Marangoni, Gabriele</creatorcontrib><creatorcontrib>Thomasset, Sarah C.</creatorcontrib><creatorcontrib>Lykoudis, Pavlos</creatorcontrib><creatorcontrib>Maglione, Manuel</creatorcontrib><creatorcontrib>Alhaboob, Nassir</creatorcontrib><creatorcontrib>Bari, Hassaan</creatorcontrib><creatorcontrib>Smith, Andrew M.</creatorcontrib><creatorcontrib>Srinivasan, Parthi</creatorcontrib><creatorcontrib>Davidson, Brian R.</creatorcontrib><creatorcontrib>Croagh, Daniel</creatorcontrib><creatorcontrib>Thakkar, Rohan</creatorcontrib><creatorcontrib>Silva, Michael A.</creatorcontrib><creatorcontrib>Lapolla, Pierfrancesco</creatorcontrib><creatorcontrib>Mingoli, Andrea</creatorcontrib><creatorcontrib>Porcu, Alberto</creatorcontrib><creatorcontrib>Shah, Nehal S.</creatorcontrib><creatorcontrib>Hamady, Zaed Z.R.</creatorcontrib><creatorcontrib>Aroori, 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(Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>HPB (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Labib, Peter L.</au><au>Denson, Jemimah</au><au>Ausania, Fabio</au><au>Pando, Elizabeth</au><au>Roberts, Keith J.</au><au>Kausar, Ambareen</au><au>Marangoni, Gabriele</au><au>Thomasset, Sarah C.</au><au>Lykoudis, Pavlos</au><au>Maglione, Manuel</au><au>Alhaboob, Nassir</au><au>Bari, Hassaan</au><au>Smith, Andrew M.</au><au>Srinivasan, Parthi</au><au>Davidson, Brian R.</au><au>Croagh, Daniel</au><au>Thakkar, Rohan</au><au>Silva, Michael A.</au><au>Lapolla, Pierfrancesco</au><au>Mingoli, Andrea</au><au>Porcu, Alberto</au><au>Shah, Nehal S.</au><au>Hamady, Zaed Z.R.</au><au>Aroori, Somaiah</au><au>Aroori, Somaiah</au><au>Labib, Peter L.</au><au>Russell, Thomas B.</au><au>Streeter, Adam</au><au>Denson, Jemimah</au><au>Puckett, Mark</au><au>Browning, Matthew G.</au><au>Ausania, Fabio</au><au>González-Abós, Carolina</au><au>Moller, Elsa G.</au><au>Taboada, Cristina D.</au><au>Roberts, Keith J.</au><au>Pande, Rupaly</au><au>Alfarah, Jameel</au><au>Kausar, Ambareen</au><au>Bandyopadhyay, Samik</au><au>Mavroeidis, Vasileios K.</au><au>Rees, Jonathan R.E.</au><au>Marangoni, Gabriele</au><au>Blege, Collaborator: Harry</au><au>Thomasset, Sarah</au><au>Frampton, Adam</au><au>Blackburn, Jessie</au><au>Lykoudis, Pavlos</au><au>Field, Daniel</au><au>Gouda, Mohammed</au><au>Bellotti, Ruben</au><au>Alhaboob, Nassir</au><au>Hamid, Hytham K.S.</au><au>Bari, Hassaan</au><au>Ahmed, Hassan</au><au>Smith, Andrew</au><au>Moriarty, Catherine</au><au>White, Louise</au><au>Bode, Kerry</au><au>Sharp, Judith</au><au>Wragg, Rosie</au><au>Jackson, Beverley</au><au>Spalding, Duncan</au><au>Fehervari, Matyas</au><au>Pai, Madhava</au><au>Alghazawi, Laith</au><au>Pericleous, Stephanos</au><au>Shaw, Conrad</au><au>Morare, Nolitha</au><au>Zaban, Mohamad K.</au><au>Bhogal, Ricky</au><au>Doyle, Joseph</au><au>Mavroeidis, Vasileios K.</au><au>Croagh, Daniel</au><au>Guerrero, Alan</au><au>Moguel, Andre</au><au>Chan, Carlos</au><au>Thakkar, Rohan</au><au>Jones, Michael</au><au>Buckley, Edward</au><au>Akter, Nasreen</au><au>Gomez, Dhanny</au><au>Gordon, Gregory</au><au>Silva, Michael</au><au>Urbonas, Tomas</au><au>Lapolla, Pierfrancesco</au><au>Mingoli, Andrea</au><au>Brachini, Gioia</au><au>Chirletti, Piero</au><au>Porcu, Alberto</au><au>Perra, Teresa</au><au>Shah, Nehal S.</au><au>Abd Kahar, Nurul N.</au><au>Hamady, Zaed</au><au>Arshad, Ali</au><au>Al-Sarrieh, Bilal</au><au>Hammoda, Mohammed</au><au>Serrablo, Alejandro</au><au>Artigas, Maria</au><au>Paterna-López, Sandra</au><aucorp>RAW Study Collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study</atitle><jtitle>HPB (Oxford, England)</jtitle><addtitle>HPB (Oxford)</addtitle><date>2023-07</date><risdate>2023</risdate><volume>25</volume><issue>7</issue><spage>788</spage><epage>797</epage><pages>788-797</pages><issn>1365-182X</issn><issn>1477-2574</issn><eissn>1477-2574</eissn><abstract>Pancreatoduodenectomy (PD) is recommended in fit patients with a resectable ampullary adenocarcinoma (AA). We aimed to identify predictors of five-year recurrence/survival.
Data were extracted from the Recurrence After Whipple's (RAW) study, a multicentre retrospective study of PD patients with a confirmed head of pancreas or periampullary malignancy (June 1st, 2012–May 31st, 2015). Patients with AA who developed recurrence/died within five-years were compared to those who did not.
394 patients were included and actual five-year survival was 54%. Recurrence affected 45% and the median time-to-recurrence was 14 months. Local only, local and distant, and distant only recurrence affected 34, 41 and 94 patients, respectively (site unknown: 7). Among those with recurrence, the most common sites were the liver (32%), local lymph nodes (14%) and lung/pleura (13%). Following multivariable tests, number of resected nodes, histological T stage > II, lymphatic invasion, perineural invasion (PNI), peripancreatic fat invasion (PPFI) and ≥1 positive resection margin correlated with increased recurrence and reduced survival. Furthermore, ≥1 positive margin, PPFI and PNI were all associated with reduced time-to-recurrence.
This multicentre retrospective study of PD outcomes identified numerous histopathological predictors of AA recurrence. Patients with these high-risk features might benefit from adjuvant therapy.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37149485</pmid><doi>10.1016/j.hpb.2023.03.010</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3004-1335</orcidid><orcidid>https://orcid.org/0000-0001-8891-2546</orcidid><orcidid>https://orcid.org/0000-0002-2720-6469</orcidid><orcidid>https://orcid.org/0000-0001-5437-9085</orcidid><orcidid>https://orcid.org/0000-0003-1479-6129</orcidid><orcidid>https://orcid.org/0000-0003-2362-9218</orcidid><orcidid>https://orcid.org/0000-0002-2236-4951</orcidid><orcidid>https://orcid.org/0000-0002-5613-6463</orcidid><orcidid>https://orcid.org/0000-0002-8188-3575</orcidid><orcidid>https://orcid.org/0000-0002-5974-187X</orcidid><orcidid>https://orcid.org/0000-0002-9762-3612</orcidid><orcidid>https://orcid.org/0000-0002-1392-2755</orcidid><orcidid>https://orcid.org/0000-0001-6836-3746</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1365-182X |
ispartof | HPB (Oxford, England), 2023-07, Vol.25 (7), p.788-797 |
issn | 1365-182X 1477-2574 1477-2574 |
language | eng |
recordid | cdi_proquest_miscellaneous_2810917001 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
subjects | Adenocarcinoma Ampulla of Vater - pathology Ampulla of Vater - surgery Common Bile Duct Neoplasms Duodenal Neoplasms - pathology Humans Neoplasm Recurrence, Local - pathology Pancreatic Neoplasms Pancreaticoduodenectomy - adverse effects Retrospective Studies |
title | Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study |
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