ERADication of STING limits inflammation
The cGAS–STING cytosolic double-stranded-DNA-sensing pathway provides protection against infection but also contributes to inflammatory pathology and thus must be tightly regulated. In this issue, Jie et al. find that endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1L–HRD1 co...
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| Veröffentlicht in: | Nature cell biology 2023-05, Vol.25 (5), p.635-636 |
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| container_title | Nature cell biology |
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| creator | Gao, Kevin MingJie Fitzgerald, Katherine A. |
| description | The cGAS–STING cytosolic double-stranded-DNA-sensing pathway provides protection against infection but also contributes to inflammatory pathology and thus must be tightly regulated. In this issue, Jie et al. find that endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1L–HRD1 controls steady-state STING levels to limit STING-driven inflammation. |
| doi_str_mv | 10.1038/s41556-023-01142-8 |
| format | Article |
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| subjects | 13/21 13/95 631/250/256/2515 631/250/256/2516 64/60 82/80 Apoptosis Biomedical and Life Sciences Cancer Cancer Research Cell Biology Cytokines Developmental Biology Enzymes Humans Infections Inflammation Kinases Life Sciences Mitochondrial DNA News & Views news-and-views Proteins Signal Transduction Stem Cells Transcription factors Viral infections |
| title | ERADication of STING limits inflammation |
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