Application of Microscopic Highly Hydrophilic Silica-Based Nanocomposites with High Surface Exposure in the Efficient Identification of Intact N‑Glycopeptides

Glycosylation of proteins regulates the life activities of organisms, while abnormalities of glycosylation sites and glycan structures occur in various serious diseases such as cancer. A separation and enrichment procedure is necessary to realize the analysis of the glycoproteins/peptides by mass sp...

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Veröffentlicht in:	Analytical chemistry (Washington) 2023-05, Vol.95 (19), p.7735-7742
Hauptverfasser:	Weng, Guoying, Wang, Baichun, Ye, Yicheng, Zhang, Qiaohong, Yan, Yinghua, Chen, Chen, Ding, Chuan-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Amino groups Antibiotics Cancer Cervical cancer Chemistry Detection limits Enrichment Female Glycan Glycopeptides Glycopeptides - analysis Glycoproteins Glycosylation Humans Hydrophilicity Hydrophobic and Hydrophilic Interactions Mass spectrometry Mass spectroscopy Nanocomposites Nanocomposites - chemistry Peptides Separation Silica Silicon dioxide Silicon Dioxide - chemistry Uterine Cervical Neoplasms Water Water chemistry
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