Nobiletin alleviates myocardial ischemia-reperfusion injury via ferroptosis in rats with type-2 diabetes mellitus

Susceptibility to myocardial ischemia-reperfusion (IR) injury in type-2 diabetes (T2DM) remains disputed, although studies have reported that ferroptosis is associated with myocardial IR injury. Nobiletin, a flavonoid isolated from citrus peels, is an antioxidant that possesses anti-inflammatory and...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-07, Vol.163, p.114795-114795, Article 114795
Hauptverfasser:	Huang, Qin, Tian, Liqun, Zhang, Yi, Qiu, Zhen, Lei, Shaoqing, Xia, Zhong-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Ferroptosis Flavones - pharmacology Flavones - therapeutic use Myocardial Ischemia - drug therapy Myocardial ischemia-reperfusion injury Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Nobiletin Rats Reperfusion Injury - metabolism Susceptibility Type-2 diabetes
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