The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study
Background Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moder...
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Veröffentlicht in: | Catheterization and cardiovascular interventions 2023-07, Vol.102 (1), p.159-165 |
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creator | Abraham, Bishoy Farina, Juan M. Fath, Ayman Abdou, Merna Elbanna, Mostafa Suppah, Mustafa Sleem, Mohamed Eldaly, Abdullah Aly, Mohamed Megaly, Michael Agasthi, Pradyumna Chao, Chieh‐Ju Fortuin, David Alsidawi, Said Ayoub, Chadi Alkhouli, Mohamad El Sabbagh, Abdallah Holmes, David Brilakis, Emmanouil S. Arsanjani, Reza |
description | Background
Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited.
Aims
This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI).
Methods
We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality.
Results
The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p |
doi_str_mv | 10.1002/ccd.30676 |
format | Article |
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Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited.
Aims
This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI).
Methods
We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality.
Results
The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p < 0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients.
Conclusion
The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.30676</identifier><identifier>PMID: 37146200</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aortic stenosis ; Aortic Valve Stenosis - complications ; Aortic Valve Stenosis - diagnostic imaging ; Aortic Valve Stenosis - surgery ; Congestive heart failure ; Heart attacks ; Heart Failure - therapy ; Hospital Mortality ; Hospitalization ; Humans ; Ischemia ; moderate arotic stenosis ; Mortality ; Multivariate analysis ; myocardia infarction ; Myocardial infarction ; Myocardial Infarction - diagnosis ; Myocardial Infarction - therapy ; Myocardial ischemia ; Non-ST Elevated Myocardial Infarction - diagnostic imaging ; Non-ST Elevated Myocardial Infarction - therapy ; Patients ; Percutaneous Coronary Intervention - adverse effects ; Retrospective Studies ; ST Elevation Myocardial Infarction - therapy ; Treatment Outcome</subject><ispartof>Catheterization and cardiovascular interventions, 2023-07, Vol.102 (1), p.159-165</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-1fa46329b38a8ce6cd828d67b64bcdf01b4fda4c9bab4b14ef3a974e3411b8343</citedby><cites>FETCH-LOGICAL-c3536-1fa46329b38a8ce6cd828d67b64bcdf01b4fda4c9bab4b14ef3a974e3411b8343</cites><orcidid>0000-0002-0037-0373 ; 0000-0001-7600-4049 ; 0000-0001-9416-9701 ; 0000-0003-3250-1312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.30676$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.30676$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37146200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abraham, Bishoy</creatorcontrib><creatorcontrib>Farina, Juan M.</creatorcontrib><creatorcontrib>Fath, Ayman</creatorcontrib><creatorcontrib>Abdou, Merna</creatorcontrib><creatorcontrib>Elbanna, Mostafa</creatorcontrib><creatorcontrib>Suppah, Mustafa</creatorcontrib><creatorcontrib>Sleem, Mohamed</creatorcontrib><creatorcontrib>Eldaly, Abdullah</creatorcontrib><creatorcontrib>Aly, Mohamed</creatorcontrib><creatorcontrib>Megaly, Michael</creatorcontrib><creatorcontrib>Agasthi, Pradyumna</creatorcontrib><creatorcontrib>Chao, Chieh‐Ju</creatorcontrib><creatorcontrib>Fortuin, David</creatorcontrib><creatorcontrib>Alsidawi, Said</creatorcontrib><creatorcontrib>Ayoub, Chadi</creatorcontrib><creatorcontrib>Alkhouli, Mohamad</creatorcontrib><creatorcontrib>El Sabbagh, Abdallah</creatorcontrib><creatorcontrib>Holmes, David</creatorcontrib><creatorcontrib>Brilakis, Emmanouil S.</creatorcontrib><creatorcontrib>Arsanjani, Reza</creatorcontrib><title>The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study</title><title>Catheterization and cardiovascular interventions</title><addtitle>Catheter Cardiovasc Interv</addtitle><description>Background
Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited.
Aims
This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI).
Methods
We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality.
Results
The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p < 0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients.
Conclusion
The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.</description><subject>Aortic stenosis</subject><subject>Aortic Valve Stenosis - complications</subject><subject>Aortic Valve Stenosis - diagnostic imaging</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Congestive heart failure</subject><subject>Heart attacks</subject><subject>Heart Failure - therapy</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Ischemia</subject><subject>moderate arotic stenosis</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>myocardia infarction</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial ischemia</subject><subject>Non-ST Elevated Myocardial Infarction - diagnostic imaging</subject><subject>Non-ST Elevated Myocardial Infarction - therapy</subject><subject>Patients</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Retrospective Studies</subject><subject>ST Elevation Myocardial Infarction - therapy</subject><subject>Treatment Outcome</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotl4WvoAE3OiimlszE3dSryC4UXA35HKGpsxMajKj9O2NtroQXJ1w_i8fyY_QESXnlBB2Ya0750QWcguN6ZSxScHk6_bmTJWQI7SX0oIQoiRTu2jECyokI2SM5s9zwL5datvjUOM2OIi6B6xD7L3FqYcuJJ-w77C2Qw7aVbA6Oq-bvKt1tL0P3SW-wu3Q5BvQ9RBxhD6GtIQcvkOWDG51gHZq3SQ43Mx99HJ78zy7nzw-3T3Mrh4nlk-5nNBaC8mZMrzUpQVpXclKJwsjhbGuJtSI2mlhldFGGCqg5loVArig1JRc8H10uvYuY3gbIPVV65OFptEdhCFVrKREUcmmKqMnf9BFGGKXX5cpTtWUM_5Fna0pm7-UItTVMvpWx1VFSfVVf5Xrr77rz-zxxjiYFtwv-dN3Bi7WwIdvYPW_qZrNrtfKT2vCj7k</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Abraham, Bishoy</creator><creator>Farina, Juan M.</creator><creator>Fath, Ayman</creator><creator>Abdou, Merna</creator><creator>Elbanna, Mostafa</creator><creator>Suppah, Mustafa</creator><creator>Sleem, Mohamed</creator><creator>Eldaly, Abdullah</creator><creator>Aly, Mohamed</creator><creator>Megaly, Michael</creator><creator>Agasthi, Pradyumna</creator><creator>Chao, Chieh‐Ju</creator><creator>Fortuin, David</creator><creator>Alsidawi, Said</creator><creator>Ayoub, Chadi</creator><creator>Alkhouli, Mohamad</creator><creator>El Sabbagh, Abdallah</creator><creator>Holmes, David</creator><creator>Brilakis, Emmanouil S.</creator><creator>Arsanjani, Reza</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0037-0373</orcidid><orcidid>https://orcid.org/0000-0001-7600-4049</orcidid><orcidid>https://orcid.org/0000-0001-9416-9701</orcidid><orcidid>https://orcid.org/0000-0003-3250-1312</orcidid></search><sort><creationdate>20230701</creationdate><title>The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study</title><author>Abraham, Bishoy ; Farina, Juan M. ; Fath, Ayman ; Abdou, Merna ; Elbanna, Mostafa ; Suppah, Mustafa ; Sleem, Mohamed ; Eldaly, Abdullah ; Aly, Mohamed ; Megaly, Michael ; Agasthi, Pradyumna ; Chao, Chieh‐Ju ; Fortuin, David ; Alsidawi, Said ; Ayoub, Chadi ; Alkhouli, Mohamad ; El Sabbagh, Abdallah ; Holmes, David ; Brilakis, Emmanouil S. ; Arsanjani, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-1fa46329b38a8ce6cd828d67b64bcdf01b4fda4c9bab4b14ef3a974e3411b8343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aortic stenosis</topic><topic>Aortic Valve Stenosis - complications</topic><topic>Aortic Valve Stenosis - diagnostic imaging</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Congestive heart failure</topic><topic>Heart attacks</topic><topic>Heart Failure - therapy</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Ischemia</topic><topic>moderate arotic stenosis</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>myocardia infarction</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocardial ischemia</topic><topic>Non-ST Elevated Myocardial Infarction - diagnostic imaging</topic><topic>Non-ST Elevated Myocardial Infarction - therapy</topic><topic>Patients</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Retrospective Studies</topic><topic>ST Elevation Myocardial Infarction - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abraham, Bishoy</creatorcontrib><creatorcontrib>Farina, Juan M.</creatorcontrib><creatorcontrib>Fath, Ayman</creatorcontrib><creatorcontrib>Abdou, Merna</creatorcontrib><creatorcontrib>Elbanna, Mostafa</creatorcontrib><creatorcontrib>Suppah, Mustafa</creatorcontrib><creatorcontrib>Sleem, Mohamed</creatorcontrib><creatorcontrib>Eldaly, Abdullah</creatorcontrib><creatorcontrib>Aly, Mohamed</creatorcontrib><creatorcontrib>Megaly, Michael</creatorcontrib><creatorcontrib>Agasthi, Pradyumna</creatorcontrib><creatorcontrib>Chao, Chieh‐Ju</creatorcontrib><creatorcontrib>Fortuin, David</creatorcontrib><creatorcontrib>Alsidawi, Said</creatorcontrib><creatorcontrib>Ayoub, Chadi</creatorcontrib><creatorcontrib>Alkhouli, Mohamad</creatorcontrib><creatorcontrib>El Sabbagh, Abdallah</creatorcontrib><creatorcontrib>Holmes, David</creatorcontrib><creatorcontrib>Brilakis, Emmanouil S.</creatorcontrib><creatorcontrib>Arsanjani, Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abraham, Bishoy</au><au>Farina, Juan M.</au><au>Fath, Ayman</au><au>Abdou, Merna</au><au>Elbanna, Mostafa</au><au>Suppah, Mustafa</au><au>Sleem, Mohamed</au><au>Eldaly, Abdullah</au><au>Aly, Mohamed</au><au>Megaly, Michael</au><au>Agasthi, Pradyumna</au><au>Chao, Chieh‐Ju</au><au>Fortuin, David</au><au>Alsidawi, Said</au><au>Ayoub, Chadi</au><au>Alkhouli, Mohamad</au><au>El Sabbagh, Abdallah</au><au>Holmes, David</au><au>Brilakis, Emmanouil S.</au><au>Arsanjani, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Catheter Cardiovasc Interv</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>102</volume><issue>1</issue><spage>159</spage><epage>165</epage><pages>159-165</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Background
Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited.
Aims
This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI).
Methods
We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality.
Results
The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p < 0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients.
Conclusion
The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37146200</pmid><doi>10.1002/ccd.30676</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0037-0373</orcidid><orcidid>https://orcid.org/0000-0001-7600-4049</orcidid><orcidid>https://orcid.org/0000-0001-9416-9701</orcidid><orcidid>https://orcid.org/0000-0003-3250-1312</orcidid></addata></record> |
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subjects | Aortic stenosis Aortic Valve Stenosis - complications Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - surgery Congestive heart failure Heart attacks Heart Failure - therapy Hospital Mortality Hospitalization Humans Ischemia moderate arotic stenosis Mortality Multivariate analysis myocardia infarction Myocardial infarction Myocardial Infarction - diagnosis Myocardial Infarction - therapy Myocardial ischemia Non-ST Elevated Myocardial Infarction - diagnostic imaging Non-ST Elevated Myocardial Infarction - therapy Patients Percutaneous Coronary Intervention - adverse effects Retrospective Studies ST Elevation Myocardial Infarction - therapy Treatment Outcome |
title | The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study |
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