The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study

Background Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moder...

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Veröffentlicht in:Catheterization and cardiovascular interventions 2023-07, Vol.102 (1), p.159-165
Hauptverfasser: Abraham, Bishoy, Farina, Juan M., Fath, Ayman, Abdou, Merna, Elbanna, Mostafa, Suppah, Mustafa, Sleem, Mohamed, Eldaly, Abdullah, Aly, Mohamed, Megaly, Michael, Agasthi, Pradyumna, Chao, Chieh‐Ju, Fortuin, David, Alsidawi, Said, Ayoub, Chadi, Alkhouli, Mohamad, El Sabbagh, Abdallah, Holmes, David, Brilakis, Emmanouil S., Arsanjani, Reza
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container_issue 1
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container_title Catheterization and cardiovascular interventions
container_volume 102
creator Abraham, Bishoy
Farina, Juan M.
Fath, Ayman
Abdou, Merna
Elbanna, Mostafa
Suppah, Mustafa
Sleem, Mohamed
Eldaly, Abdullah
Aly, Mohamed
Megaly, Michael
Agasthi, Pradyumna
Chao, Chieh‐Ju
Fortuin, David
Alsidawi, Said
Ayoub, Chadi
Alkhouli, Mohamad
El Sabbagh, Abdallah
Holmes, David
Brilakis, Emmanouil S.
Arsanjani, Reza
description Background Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI). Methods We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality. Results The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p 
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However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI). Methods We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality. Results The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p &lt; 0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients. Conclusion The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.</description><identifier>ISSN: 1522-1946</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.30676</identifier><identifier>PMID: 37146200</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aortic stenosis ; Aortic Valve Stenosis - complications ; Aortic Valve Stenosis - diagnostic imaging ; Aortic Valve Stenosis - surgery ; Congestive heart failure ; Heart attacks ; Heart Failure - therapy ; Hospital Mortality ; Hospitalization ; Humans ; Ischemia ; moderate arotic stenosis ; Mortality ; Multivariate analysis ; myocardia infarction ; Myocardial infarction ; Myocardial Infarction - diagnosis ; Myocardial Infarction - therapy ; Myocardial ischemia ; Non-ST Elevated Myocardial Infarction - diagnostic imaging ; Non-ST Elevated Myocardial Infarction - therapy ; Patients ; Percutaneous Coronary Intervention - adverse effects ; Retrospective Studies ; ST Elevation Myocardial Infarction - therapy ; Treatment Outcome</subject><ispartof>Catheterization and cardiovascular interventions, 2023-07, Vol.102 (1), p.159-165</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-1fa46329b38a8ce6cd828d67b64bcdf01b4fda4c9bab4b14ef3a974e3411b8343</citedby><cites>FETCH-LOGICAL-c3536-1fa46329b38a8ce6cd828d67b64bcdf01b4fda4c9bab4b14ef3a974e3411b8343</cites><orcidid>0000-0002-0037-0373 ; 0000-0001-7600-4049 ; 0000-0001-9416-9701 ; 0000-0003-3250-1312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fccd.30676$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fccd.30676$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37146200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abraham, Bishoy</creatorcontrib><creatorcontrib>Farina, Juan M.</creatorcontrib><creatorcontrib>Fath, Ayman</creatorcontrib><creatorcontrib>Abdou, Merna</creatorcontrib><creatorcontrib>Elbanna, Mostafa</creatorcontrib><creatorcontrib>Suppah, Mustafa</creatorcontrib><creatorcontrib>Sleem, Mohamed</creatorcontrib><creatorcontrib>Eldaly, Abdullah</creatorcontrib><creatorcontrib>Aly, Mohamed</creatorcontrib><creatorcontrib>Megaly, Michael</creatorcontrib><creatorcontrib>Agasthi, Pradyumna</creatorcontrib><creatorcontrib>Chao, Chieh‐Ju</creatorcontrib><creatorcontrib>Fortuin, David</creatorcontrib><creatorcontrib>Alsidawi, Said</creatorcontrib><creatorcontrib>Ayoub, Chadi</creatorcontrib><creatorcontrib>Alkhouli, Mohamad</creatorcontrib><creatorcontrib>El Sabbagh, Abdallah</creatorcontrib><creatorcontrib>Holmes, David</creatorcontrib><creatorcontrib>Brilakis, Emmanouil S.</creatorcontrib><creatorcontrib>Arsanjani, Reza</creatorcontrib><title>The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study</title><title>Catheterization and cardiovascular interventions</title><addtitle>Catheter Cardiovasc Interv</addtitle><description>Background Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI). Methods We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality. Results The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p &lt; 0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients. Conclusion The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.</description><subject>Aortic stenosis</subject><subject>Aortic Valve Stenosis - complications</subject><subject>Aortic Valve Stenosis - diagnostic imaging</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Congestive heart failure</subject><subject>Heart attacks</subject><subject>Heart Failure - therapy</subject><subject>Hospital Mortality</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Ischemia</subject><subject>moderate arotic stenosis</subject><subject>Mortality</subject><subject>Multivariate analysis</subject><subject>myocardia infarction</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial ischemia</subject><subject>Non-ST Elevated Myocardial Infarction - diagnostic imaging</subject><subject>Non-ST Elevated Myocardial Infarction - therapy</subject><subject>Patients</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Retrospective Studies</subject><subject>ST Elevation Myocardial Infarction - therapy</subject><subject>Treatment Outcome</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtKAzEUhoMotl4WvoAE3OiimlszE3dSryC4UXA35HKGpsxMajKj9O2NtroQXJ1w_i8fyY_QESXnlBB2Ya0750QWcguN6ZSxScHk6_bmTJWQI7SX0oIQoiRTu2jECyokI2SM5s9zwL5datvjUOM2OIi6B6xD7L3FqYcuJJ-w77C2Qw7aVbA6Oq-bvKt1tL0P3SW-wu3Q5BvQ9RBxhD6GtIQcvkOWDG51gHZq3SQ43Mx99HJ78zy7nzw-3T3Mrh4nlk-5nNBaC8mZMrzUpQVpXclKJwsjhbGuJtSI2mlhldFGGCqg5loVArig1JRc8H10uvYuY3gbIPVV65OFptEdhCFVrKREUcmmKqMnf9BFGGKXX5cpTtWUM_5Fna0pm7-UItTVMvpWx1VFSfVVf5Xrr77rz-zxxjiYFtwv-dN3Bi7WwIdvYPW_qZrNrtfKT2vCj7k</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Abraham, Bishoy</creator><creator>Farina, Juan M.</creator><creator>Fath, Ayman</creator><creator>Abdou, Merna</creator><creator>Elbanna, Mostafa</creator><creator>Suppah, Mustafa</creator><creator>Sleem, Mohamed</creator><creator>Eldaly, Abdullah</creator><creator>Aly, Mohamed</creator><creator>Megaly, Michael</creator><creator>Agasthi, Pradyumna</creator><creator>Chao, Chieh‐Ju</creator><creator>Fortuin, David</creator><creator>Alsidawi, Said</creator><creator>Ayoub, Chadi</creator><creator>Alkhouli, Mohamad</creator><creator>El Sabbagh, Abdallah</creator><creator>Holmes, David</creator><creator>Brilakis, Emmanouil S.</creator><creator>Arsanjani, Reza</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0037-0373</orcidid><orcidid>https://orcid.org/0000-0001-7600-4049</orcidid><orcidid>https://orcid.org/0000-0001-9416-9701</orcidid><orcidid>https://orcid.org/0000-0003-3250-1312</orcidid></search><sort><creationdate>20230701</creationdate><title>The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study</title><author>Abraham, Bishoy ; Farina, Juan M. ; Fath, Ayman ; Abdou, Merna ; Elbanna, Mostafa ; Suppah, Mustafa ; Sleem, Mohamed ; Eldaly, Abdullah ; Aly, Mohamed ; Megaly, Michael ; Agasthi, Pradyumna ; Chao, Chieh‐Ju ; Fortuin, David ; Alsidawi, Said ; Ayoub, Chadi ; Alkhouli, Mohamad ; El Sabbagh, Abdallah ; Holmes, David ; Brilakis, Emmanouil S. ; Arsanjani, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-1fa46329b38a8ce6cd828d67b64bcdf01b4fda4c9bab4b14ef3a974e3411b8343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aortic stenosis</topic><topic>Aortic Valve Stenosis - complications</topic><topic>Aortic Valve Stenosis - diagnostic imaging</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Congestive heart failure</topic><topic>Heart attacks</topic><topic>Heart Failure - therapy</topic><topic>Hospital Mortality</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Ischemia</topic><topic>moderate arotic stenosis</topic><topic>Mortality</topic><topic>Multivariate analysis</topic><topic>myocardia infarction</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocardial ischemia</topic><topic>Non-ST Elevated Myocardial Infarction - diagnostic imaging</topic><topic>Non-ST Elevated Myocardial Infarction - therapy</topic><topic>Patients</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Retrospective Studies</topic><topic>ST Elevation Myocardial Infarction - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abraham, Bishoy</creatorcontrib><creatorcontrib>Farina, Juan M.</creatorcontrib><creatorcontrib>Fath, Ayman</creatorcontrib><creatorcontrib>Abdou, Merna</creatorcontrib><creatorcontrib>Elbanna, Mostafa</creatorcontrib><creatorcontrib>Suppah, Mustafa</creatorcontrib><creatorcontrib>Sleem, Mohamed</creatorcontrib><creatorcontrib>Eldaly, Abdullah</creatorcontrib><creatorcontrib>Aly, Mohamed</creatorcontrib><creatorcontrib>Megaly, Michael</creatorcontrib><creatorcontrib>Agasthi, Pradyumna</creatorcontrib><creatorcontrib>Chao, Chieh‐Ju</creatorcontrib><creatorcontrib>Fortuin, David</creatorcontrib><creatorcontrib>Alsidawi, Said</creatorcontrib><creatorcontrib>Ayoub, Chadi</creatorcontrib><creatorcontrib>Alkhouli, Mohamad</creatorcontrib><creatorcontrib>El Sabbagh, Abdallah</creatorcontrib><creatorcontrib>Holmes, David</creatorcontrib><creatorcontrib>Brilakis, Emmanouil S.</creatorcontrib><creatorcontrib>Arsanjani, Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abraham, Bishoy</au><au>Farina, Juan M.</au><au>Fath, Ayman</au><au>Abdou, Merna</au><au>Elbanna, Mostafa</au><au>Suppah, Mustafa</au><au>Sleem, Mohamed</au><au>Eldaly, Abdullah</au><au>Aly, Mohamed</au><au>Megaly, Michael</au><au>Agasthi, Pradyumna</au><au>Chao, Chieh‐Ju</au><au>Fortuin, David</au><au>Alsidawi, Said</au><au>Ayoub, Chadi</au><au>Alkhouli, Mohamad</au><au>El Sabbagh, Abdallah</au><au>Holmes, David</au><au>Brilakis, Emmanouil S.</au><au>Arsanjani, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Catheter Cardiovasc Interv</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>102</volume><issue>1</issue><spage>159</spage><epage>165</epage><pages>159-165</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><abstract>Background Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI). Methods We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality. Results The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p &lt; 0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients. Conclusion The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37146200</pmid><doi>10.1002/ccd.30676</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0037-0373</orcidid><orcidid>https://orcid.org/0000-0001-7600-4049</orcidid><orcidid>https://orcid.org/0000-0001-9416-9701</orcidid><orcidid>https://orcid.org/0000-0003-3250-1312</orcidid></addata></record>
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subjects Aortic stenosis
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - diagnostic imaging
Aortic Valve Stenosis - surgery
Congestive heart failure
Heart attacks
Heart Failure - therapy
Hospital Mortality
Hospitalization
Humans
Ischemia
moderate arotic stenosis
Mortality
Multivariate analysis
myocardia infarction
Myocardial infarction
Myocardial Infarction - diagnosis
Myocardial Infarction - therapy
Myocardial ischemia
Non-ST Elevated Myocardial Infarction - diagnostic imaging
Non-ST Elevated Myocardial Infarction - therapy
Patients
Percutaneous Coronary Intervention - adverse effects
Retrospective Studies
ST Elevation Myocardial Infarction - therapy
Treatment Outcome
title The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study
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