Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal

Remote tumors disrupt the bone marrow (BM) ecosystem (BME), eliciting the overproduction of BM-derived immunosuppressive cells. However, the underlying mechanisms remain poorly understood. Herein, we characterized breast and lung cancer-induced BME shifts pre- and post-tumor removal. Remote tumors p...

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Veröffentlicht in:	Cell stem cell 2023-05, Vol.30 (5), p.648-664.e8
Hauptverfasser:	Hao, Xiaoxin, Shen, Yichao, Chen, Nan, Zhang, Weijie, Valverde, Elizabeth, Wu, Ling, Chan, Hilda L., Xu, Zhan, Yu, Liqun, Gao, Yang, Bado, Igor, Michie, Laura Natalee, Rivas, Charlotte Helena, Dominguez, Luis Becerra, Aguirre, Sergio, Pingel, Bradley C., Wu, Yi-Hsuan, Liu, Fengshuo, Ding, Yunfeng, Edwards, David G., Liu, Jun, Alexander, Angela, Ueno, Naoto T., Hsueh, Po-Ren, Tu, Chih-Yen, Liu, Liang-Chih, Chen, Shu-Hsia, Hung, Mien-Chie, Lim, Bora, Zhang, Xiang H.-F.
Format:	Artikel
Sprache:	eng
Schlagworte:	bone marrow niches cancer Ecosystem hematopoiesis Hematopoietic Stem Cells hematopoietic stem/progenitor cells High-Temperature Requirement A Serine Peptidase 1 - pharmacology Humans Immunosuppression Therapy immunotherapies Matrix Metalloproteinase 13 - pharmacology MDSCs Myelopoiesis Neoplasms - pathology osteoprogenitor scRNA-seq systemic immunosuppression
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