Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer
Intestinal‐type gastric cancer arises in a field of precancerous metaplastic lineages. Two types of metaplastic glands are found in the stomachs of humans with the characteristics of pyloric metaplasia or intestinal metaplasia. While spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages...
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| Veröffentlicht in: | The Journal of pathology 2023-06, Vol.260 (2), p.109-111 |
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| container_title | The Journal of pathology |
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| creator | Goldenring, James R |
| description | Intestinal‐type gastric cancer arises in a field of precancerous metaplastic lineages. Two types of metaplastic glands are found in the stomachs of humans with the characteristics of pyloric metaplasia or intestinal metaplasia. While spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages have been identified in both pyloric metaplasia and incomplete intestinal metaplasia, it has been unclear whether SPEM lineages or intestinal lineages can give rise to dysplasia and cancer. A recent article published in The Journal of Pathology describes a patient with evidence of an activating Kras(G12D) mutation in SPEM that is propagated into adenomatous and cancerous lesions which manifest further oncogenic mutations. This case therefore supports the concept that SPEM lineages can serve as a direct precursor for dysplasia and intestinal‐type gastric cancer. © 2023 The Pathological Society of Great Britain and Ireland. |
| doi_str_mv | 10.1002/path.6089 |
| format | Article |
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This case therefore supports the concept that SPEM lineages can serve as a direct precursor for dysplasia and intestinal‐type gastric cancer. © 2023 The Pathological Society of Great Britain and Ireland.</description><subject>Cell Lineage</subject><subject>Dysplasia</subject><subject>Gastric cancer</subject><subject>Gastric Mucosa - pathology</subject><subject>Humans</subject><subject>intestinal metaplasia</subject><subject>Intestine</subject><subject>Metaplasia</subject><subject>Metaplasia - pathology</subject><subject>Mutation</subject><subject>Peptides - metabolism</subject><subject>pyloric metaplasia</subject><subject>Spasmolytic polypeptide</subject><subject>SPEM</subject><subject>Stomach Neoplasms - pathology</subject><issn>0022-3417</issn><issn>1096-9896</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtK7TAUhoMour0MfIFDwIkOqkmapOlQNl4OKArquKTpak-kl5h0o3vmI_iMPonp2epAcLL-wfr4WetDaJ-SY0oIO3F6_HcsicrX0IySXCa5yuU6msUdS1JOsy20HcIjISTPhdhEW2lGuVBSzFBz53TohnY5WoNdTAdutBW8v77Bi_MQgu0b3MGoXauD1fjw7vbs-ggbaFvc2h50AwEb3eMScJyDt42NUeNGh9HH0rgz4HfRRq3bAHufuYMezs_u55fJ1c3F3_npVWJSpfKEE8mFzCojs6xONakyVlY1KEZZ_IOXqibGiKoCIkqZ1ZlkHBRQwXNOKRMm3UGHq17nh6cFhLHobJiO1T0Mi1AwFQVRzpmM6MEP9HFY-D5eN1GMEyUkjdTRijJ-CMFDXThvO-2XBSXFZL-Y7BeT_cj--WxclB1U3-SX7gicrIBn28Ly96bi9vT-8n_lB4e0jyk</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Goldenring, James R</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7833-2940</orcidid></search><sort><creationdate>202306</creationdate><title>Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer</title><author>Goldenring, James R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3889-4064567dc677f3a0d72bdfe82123414b8f0cc5dde05b67f7624e8e154941125c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cell Lineage</topic><topic>Dysplasia</topic><topic>Gastric cancer</topic><topic>Gastric Mucosa - pathology</topic><topic>Humans</topic><topic>intestinal metaplasia</topic><topic>Intestine</topic><topic>Metaplasia</topic><topic>Metaplasia - pathology</topic><topic>Mutation</topic><topic>Peptides - metabolism</topic><topic>pyloric metaplasia</topic><topic>Spasmolytic polypeptide</topic><topic>SPEM</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldenring, James R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldenring, James R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J Pathol</addtitle><date>2023-06</date><risdate>2023</risdate><volume>260</volume><issue>2</issue><spage>109</spage><epage>111</epage><pages>109-111</pages><issn>0022-3417</issn><issn>1096-9896</issn><eissn>1096-9896</eissn><abstract>Intestinal‐type gastric cancer arises in a field of precancerous metaplastic lineages. 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| ispartof | The Journal of pathology, 2023-06, Vol.260 (2), p.109-111 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Cell Lineage Dysplasia Gastric cancer Gastric Mucosa - pathology Humans intestinal metaplasia Intestine Metaplasia Metaplasia - pathology Mutation Peptides - metabolism pyloric metaplasia Spasmolytic polypeptide SPEM Stomach Neoplasms - pathology |
| title | Spasmolytic polypeptide‐expressing metaplasia (SPEM) cell lineages can be an origin of gastric cancer |
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