Danggui Buxue decoction ameliorates mitochondrial biogenesis and cognitive deficits through upregulating histone H4 lysine 12 acetylation in APP/PS1 mice

Danggui Buxue decoction (DBD) is a classic herbal decoction consisting of Astragali Radix (AR) and Angelica Sinensis Radix (ASR) with a 5:1 wt ratio, which can supplement ‘blood’ and ‘qi’ (vital energy) for the treatment of clinical diseases. According to Traditional Chinese Medicine (TCM) theory, d...

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Veröffentlicht in:	Journal of ethnopharmacology 2023-09, Vol.313, p.116554-116554, Article 116554
Hauptverfasser:	Chai, Gao-shang, Gong, Juan, Wu, Jia-jun, Ma, Rui-kun, Zhu, Jun, Jia, Dong-dong, Zhang, Yu-qi, Zhai, Xiao-run, Sun, Hong-xu, Nie, Yun juan, Zhao, Peng, Xu, Yi-liang, Yu, Hai tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Alzheimer Disease - drug therapy Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases Amyloid β Animals Aspartic Acid Endopeptidases - metabolism Aspartic Acid Endopeptidases - therapeutic use Cognition Danggui Buxue decoction Disease Models, Animal Histone acetylation Histones - metabolism Lysine - metabolism Lysine - therapeutic use Mice Mice, Transgenic Mitochondrial biogenesis Neurodegenerative Diseases Organelle Biogenesis Protein Processing, Post-Translational Traditional Chinese medicine
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