Clusterin Neutralizes the Inflammatory and Cytotoxic Properties of Extracellular Histones in Sepsis

Extracellular histones, released into the surrounding environment during extensive cell death, promote inflammation and cell death, and these deleterious roles have been well documented in sepsis. Clusterin (CLU) is a ubiquitous extracellular protein that chaperones misfolded proteins and promotes t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	American journal of respiratory and critical care medicine 2023-07, Vol.208 (2), p.176-187
Hauptverfasser:	Augusto, Jean-François, Beauvillain, Céline, Poli, Caroline, Paolini, Léa, Tournier, Isabelle, Pignon, Pascale, Blanchard, Simon, Preisser, Laurence, Soleti, Raffaella, Delépine, Chloé, Monnier, Marine, Douchet, Isabelle, Asfar, Pierre, Beloncle, François, Guisset, Olivier, Prével, Renaud, Mercat, Alain, Vinatier, Emeline, Goret, Julien, Subra, Jean-François, Couez, Dominique, Wilson, Mark R, Blanco, Patrick, Jeannin, Pascale, Delneste, Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents Autophagy Cell Death Clusterin - metabolism Cytokines Cytotoxicity Histones - metabolism Inflammation Mice Pathogenesis Sepsis Sepsis - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!