Dual enzyme-like Co–FeSe2 nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy
Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency of a single nanozyme is limited by the complexity of the tumor microenvironment (hy...
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Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2023-05, Vol.11 (19), p.4274-4286 |
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container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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creator | Zhang, Jingge Enna Ha Li, Danyang He, Shuqing Wang, Luyang Kuang, Shaolong Hu, Junqing |
description | Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency of a single nanozyme is limited by the complexity of the tumor microenvironment (hypoxia, GSH overexpression, etc.). In order to overcome these problems, we designed flower-like Co-doped FeSe2 (Co–FeSe2) nanozymes by a simple wet chemistry method. Co–FeSe2 nanozymes not only exhibit high POD and OXD-mimicking activities for facile kinetics, but also effectively consume over-expressed glutathione (GSH), inhibiting the consumption of generated ROS and destroying the metabolic balance of the tumor microenvironment. These catalytic reactions trigger cell death through apoptosis and ferroptosis dual pathways. More importantly, under the NIR II laser irradiation, the catalytic activities of Co–FeSe2 nanozymes are boosted, confirming the photothermal and catalytic synergistic tumor therapy. This study takes advantage of self-cascading engineering that offers new ideas for designing efficient redox nanozymes and promoting their clinical translation. |
doi_str_mv | 10.1039/d3tb00220a |
format | Article |
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However, the catalytic efficiency of a single nanozyme is limited by the complexity of the tumor microenvironment (hypoxia, GSH overexpression, etc.). In order to overcome these problems, we designed flower-like Co-doped FeSe2 (Co–FeSe2) nanozymes by a simple wet chemistry method. Co–FeSe2 nanozymes not only exhibit high POD and OXD-mimicking activities for facile kinetics, but also effectively consume over-expressed glutathione (GSH), inhibiting the consumption of generated ROS and destroying the metabolic balance of the tumor microenvironment. These catalytic reactions trigger cell death through apoptosis and ferroptosis dual pathways. More importantly, under the NIR II laser irradiation, the catalytic activities of Co–FeSe2 nanozymes are boosted, confirming the photothermal and catalytic synergistic tumor therapy. This study takes advantage of self-cascading engineering that offers new ideas for designing efficient redox nanozymes and promoting their clinical translation.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d3tb00220a</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Apoptosis ; Cancer therapies ; Cell death ; Ferroptosis ; Glutathione ; Hypoxia ; Irradiation ; Metabolism ; Reactive oxygen species ; Therapy ; Tumor cells ; Tumor microenvironment ; Tumors</subject><ispartof>Journal of materials chemistry. 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B, Materials for biology and medicine</title><description>Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency of a single nanozyme is limited by the complexity of the tumor microenvironment (hypoxia, GSH overexpression, etc.). In order to overcome these problems, we designed flower-like Co-doped FeSe2 (Co–FeSe2) nanozymes by a simple wet chemistry method. Co–FeSe2 nanozymes not only exhibit high POD and OXD-mimicking activities for facile kinetics, but also effectively consume over-expressed glutathione (GSH), inhibiting the consumption of generated ROS and destroying the metabolic balance of the tumor microenvironment. These catalytic reactions trigger cell death through apoptosis and ferroptosis dual pathways. More importantly, under the NIR II laser irradiation, the catalytic activities of Co–FeSe2 nanozymes are boosted, confirming the photothermal and catalytic synergistic tumor therapy. This study takes advantage of self-cascading engineering that offers new ideas for designing efficient redox nanozymes and promoting their clinical translation.</description><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cell death</subject><subject>Ferroptosis</subject><subject>Glutathione</subject><subject>Hypoxia</subject><subject>Irradiation</subject><subject>Metabolism</subject><subject>Reactive oxygen species</subject><subject>Therapy</subject><subject>Tumor cells</subject><subject>Tumor microenvironment</subject><subject>Tumors</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdjs9Kw0AYxBdRsNRefIIFL16i-y_J5ijVtgFRsAreypfdLzZ1m9TshhJPvoNv6JMYUDw4lxmYH8MQcsrZBWcyu7QyFIwJweCAjASLWZTGXB_-ZfZ8TCbeb9ggzRMt1Yj46w4cxfq932Lkqlek0-br43OGSxS0hropXbPH1tN9FdZ0vlxQiy8tWAhVU1MDOygqV4Welk1L7_IHmucR1muoDdqhDuD6UBkauu3QhzW2sOtPyFEJzuPk18fkaXbzOF1Et_fzfHp1G-0ET0JU6EIrzhOJgqNMBZe6VKB4hllhMgsqthIAGbcFWmYyEWvkkKSGl2BAgRyT85_dXdu8dejDalt5g85BjU3nV0KzLFY8zdiAnv1DN03X1sO7geJKMpFoLr8B89JspQ</recordid><startdate>20230517</startdate><enddate>20230517</enddate><creator>Zhang, Jingge</creator><creator>Enna Ha</creator><creator>Li, Danyang</creator><creator>He, Shuqing</creator><creator>Wang, Luyang</creator><creator>Kuang, Shaolong</creator><creator>Hu, Junqing</creator><general>Royal Society of Chemistry</general><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20230517</creationdate><title>Dual enzyme-like Co–FeSe2 nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy</title><author>Zhang, Jingge ; Enna Ha ; Li, Danyang ; He, Shuqing ; Wang, Luyang ; Kuang, Shaolong ; Hu, Junqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p216t-b8b841163e21e372138f4a419e9bc9da45d3aae01dbed0c9258e1a67c1faca4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cell death</topic><topic>Ferroptosis</topic><topic>Glutathione</topic><topic>Hypoxia</topic><topic>Irradiation</topic><topic>Metabolism</topic><topic>Reactive oxygen species</topic><topic>Therapy</topic><topic>Tumor cells</topic><topic>Tumor microenvironment</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Jingge</creatorcontrib><creatorcontrib>Enna Ha</creatorcontrib><creatorcontrib>Li, Danyang</creatorcontrib><creatorcontrib>He, Shuqing</creatorcontrib><creatorcontrib>Wang, Luyang</creatorcontrib><creatorcontrib>Kuang, Shaolong</creatorcontrib><creatorcontrib>Hu, Junqing</creatorcontrib><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Jingge</au><au>Enna Ha</au><au>Li, Danyang</au><au>He, Shuqing</au><au>Wang, Luyang</au><au>Kuang, Shaolong</au><au>Hu, Junqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dual enzyme-like Co–FeSe2 nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><date>2023-05-17</date><risdate>2023</risdate><volume>11</volume><issue>19</issue><spage>4274</spage><epage>4286</epage><pages>4274-4286</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Nanozymes mediated catalytic therapy can produce toxic reactive oxygen species (ROS) and destroy the metabolic balance of tumor cells, providing a new direction for cancer treatment. However, the catalytic efficiency of a single nanozyme is limited by the complexity of the tumor microenvironment (hypoxia, GSH overexpression, etc.). In order to overcome these problems, we designed flower-like Co-doped FeSe2 (Co–FeSe2) nanozymes by a simple wet chemistry method. Co–FeSe2 nanozymes not only exhibit high POD and OXD-mimicking activities for facile kinetics, but also effectively consume over-expressed glutathione (GSH), inhibiting the consumption of generated ROS and destroying the metabolic balance of the tumor microenvironment. These catalytic reactions trigger cell death through apoptosis and ferroptosis dual pathways. More importantly, under the NIR II laser irradiation, the catalytic activities of Co–FeSe2 nanozymes are boosted, confirming the photothermal and catalytic synergistic tumor therapy. This study takes advantage of self-cascading engineering that offers new ideas for designing efficient redox nanozymes and promoting their clinical translation.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/d3tb00220a</doi><tpages>13</tpages></addata></record> |
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subjects | Apoptosis Cancer therapies Cell death Ferroptosis Glutathione Hypoxia Irradiation Metabolism Reactive oxygen species Therapy Tumor cells Tumor microenvironment Tumors |
title | Dual enzyme-like Co–FeSe2 nanoflowers with GSH degradation capability for NIR II-enhanced catalytic tumor therapy |
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