Conjugation of amino-containing drugs to polysaccharides by tosylation: amphotericin B–arabinogalactan conjugates

The coupling of amphotericin-B (AmB), a water-insoluble antifungal and antileishmanial agent, to arabinogalactan (AG) via tosylate or mesylate derivatives was investigated as a method for the conjugation of amino-containing drugs to polysaccharides. In the first step, AG was reacted with tosyl- or m...

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Veröffentlicht in:	Biomaterials 2004-07, Vol.25 (15), p.3049-3057
Hauptverfasser:	Ehrenfreund-Kleinman, Tirsta, Golenser, Jacob, Domb, Abraham J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - administration & dosage Amino Acids - chemistry Amino Acids - toxicity Amphotericin B - administration & dosage Amphotericin B - chemistry Amphotericin B - toxicity Amphotericin-B Animals Antifungal Agents - administration & dosage Antifungal Agents - chemistry Antifungal Agents - toxicity Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - chemistry Antiprotozoal Agents - toxicity Arabinogalactan Candida albicans Candida albicans - drug effects Dose-Response Relationship, Drug Drug Delivery Systems - methods Drug Evaluation Drug Stability Galactans - administration & dosage Galactans - chemistry Galactans - toxicity Hemolysis - drug effects Humans Leishmania major Leishmania major - drug effects Male Mesylate Mice Mice, Inbred BALB C Molecular Conformation Pharmaceutical Vehicles Polysaccharides - administration & dosage Polysaccharides - chemistry Polysaccharides - toxicity Sheep Solubility Survival Tosylate Water - chemistry Water-soluble conjugate
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