Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling

Liver fibrosis is a key global health care burden. Sclareol, isolated from Salvia sclarea, possesses various biological activities. Its effect on liver fibrosis remains unknown. This study was proposed to evaluate the antifibrotic activity of sclareol (SCL) and explore its underlying mechanisms. Sti...

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Veröffentlicht in:	Phytotherapy research 2023-09, Vol.37 (9), p.3898-3912
Hauptverfasser:	Ge, Mao-Xu, Niu, Wei-Xiao, Bao, Yun-Yang, Lu, Zhen-Ning, He, Hong-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Bile ducts Biological effects Carbon tetrachloride Fibrosis Global health In vivo methods and tests Injury prevention Liver Phosphorylation Public health Stat3 protein Stellate cells SUMO protein
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