Consequences of incorporating thiaproline and its oxidized derivatives into collagen triple helices

(2R)‐4‐thiaproline (Thp) is an analog of proline, replacing Cγ in the pyrrolidine ring with sulfur. Its thiazolidine ring easily interconverts between endo and exo puckers due to a small energy barrier, which leads to destabilize polyproline helices. Collagen, composed of three polyproline II helice...

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Veröffentlicht in:	Protein science 2023-06, Vol.32 (6), p.e4650-n/a
Hauptverfasser:	Hsu, Tsai‐Ling, Horng, Jia‐Cherng
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomaterials Biomedical materials Biomimetics Calorimetry Circular dichroism Collagen Collagen - chemical synthesis Collagen - chemistry collagen‐mimetic peptide Conformation Destabilization Dichroism Differential scanning calorimetry Dioxides Helices Hydroxyproline Kinetics Oxidation Peptides Polyproline Proline Protein Stability Pyrrolidine ring pucker Sulfur Thermodynamics thiaproline Thiazolidines - chemistry triple helix
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