A Reagentless Biosensing Assembly Based on Quantum Dot-Donor Förster Resonance Energy Transfer

A Reagentless Biosensing Assembly Based on Quantum Dot-Donor Förster Resonance Energy Transfer

On the surface of a quantum dot (QD), maltose‐binding protein (MBP, white and yellow in Figure) labeled with a cyanine dye (red) self‐assembles, resulting in F?rster resonance energy transfer between the acceptor dye and the QD donor. Upon binding maltose, MBP undergoes a conformational change (whit...

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Veröffentlicht in:Advanced materials (Weinheim) 2005-10, Vol.17 (20), p.2450-2455
Hauptverfasser: Medintz, I. L., Clapp, A. R., Melinger, J. S., Deschamps, J. R., Mattoussi, H.
Format: Artikel
Sprache:eng
Schlagworte:
Biosensors
core-shell
Dyes
Energy transfer
inorganic
Nanoparticles
Nanoparticles, inorganic
Quantum dots
Quantum dots, core–shell
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Zusammenfassung:On the surface of a quantum dot (QD), maltose‐binding protein (MBP, white and yellow in Figure) labeled with a cyanine dye (red) self‐assembles, resulting in F?rster resonance energy transfer between the acceptor dye and the QD donor. Upon binding maltose, MBP undergoes a conformational change (white ⇌ yellow), causing concentration‐dependent photoluminescence changes.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200500722