Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact?
Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached r...
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| Veröffentlicht in: | American journal of physiology. Lung cellular and molecular physiology 2023-07, Vol.325 (1), p.L9-L16 |
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| container_title | American journal of physiology. Lung cellular and molecular physiology |
| container_volume | 325 |
| creator | Lilien, Thijs A van Meenen, David M P Schultz, Marcus J Bos, Lieuwe D J Bem, Reinout A |
| description | Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). Here, we suggest that in current clinical practice in the setting of ARDS HILI may actually be of less importance than other ventilator-related factors. |
| doi_str_mv | 10.1152/ajplung.00443.2022 |
| format | Article |
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Lung cellular and molecular physiology</jtitle><addtitle>Am J Physiol Lung Cell Mol Physiol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>325</volume><issue>1</issue><spage>L9</spage><epage>L16</epage><pages>L9-L16</pages><issn>1040-0605</issn><eissn>1522-1504</eissn><abstract>Over the past decade, the interest in oxygen toxicity has led to various observational studies and randomized clinical trials in critically ill patients, assessing the association with outcomes and the potential benefit of restrictive oxygenation targets. Yet to date, no consensus has been reached regarding the clinical impact of hyperoxia and hyperoxemia. In this perspective article, we explore the experimental and clinical evidence on hyperoxia-induced lung injury (HILI) and assess its relative impact in current critical care practice, specifically in patients who require oxygen therapy due to acute respiratory distress syndrome (ARDS). 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| fulltext | fulltext |
| identifier | ISSN: 1040-0605 |
| ispartof | American journal of physiology. Lung cellular and molecular physiology, 2023-07, Vol.325 (1), p.L9-L16 |
| issn | 1040-0605 1522-1504 |
| language | eng |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Clinical trials Humans Hyperoxia Hyperoxia - complications Lung Injury Lungs Oxygen Oxygenation Respiration, Artificial - adverse effects Respiratory distress syndrome Respiratory Distress Syndrome - etiology Toxicity |
| title | Hyperoxia-induced lung injury in acute respiratory distress syndrome: what is its relative impact? |
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