Pulse Power Generation Chronoamperometry as an Advanced Readout for (Bio)sensors: Application for Noninvasive Diabetes Monitoring
We propose pulse power generation (PPG) amperometry as an advanced readout realized for Prussian blue (PB)-based (bio)sensors. In contrast to the conventional power generation mode, when the current response is generated upon continuous short-circuiting, the suggested pulse regime is fulfilled by p...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2023-05, Vol.95 (19), p.7528-7535 |
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| container_title | Analytical chemistry (Washington) |
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| creator | Komkova, Maria A. Eliseev, Artem A. Kasimovskaya, Valeria S. Poyarkov, Andrei A. Eliseev, Andrei A. Karyakin, Arkady A. |
| description | We propose pulse power generation (PPG) amperometry as an advanced readout realized for Prussian blue (PB)-based (bio)sensors. In contrast to the conventional power generation mode, when the current response is generated upon continuous short-circuiting, the suggested pulse regime is fulfilled by periodic opening and shorting of the circuit. Despite PB being electroactive, the pulse readout is advantageous over conventional steady-state power generation, providing up to a 15-fold increased signal-to-background ratio as well as dramatically improved sensitivity exceeding 10 A·M–1·cm–2 for H2O2 sensors and 3.9 A·M–1·cm–2 for glucose biosensors. Such analytical performance characteristics are, most probably, achieved due to the enrichment of the diffusion layer by analyte mass transfer from the bulk upon opening of the circuit. Due to an improved sensitivity-to-background ratio, reduced flow-rate dependence, and enhanced operational stability, the regime allows reliable monitoring of blood glucose variations through sweat analysis with the on-skin device. |
| doi_str_mv | 10.1021/acs.analchem.2c05746 |
| format | Article |
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In contrast to the conventional power generation mode, when the current response is generated upon continuous short-circuiting, the suggested pulse regime is fulfilled by periodic opening and shorting of the circuit. Despite PB being electroactive, the pulse readout is advantageous over conventional steady-state power generation, providing up to a 15-fold increased signal-to-background ratio as well as dramatically improved sensitivity exceeding 10 A·M–1·cm–2 for H2O2 sensors and 3.9 A·M–1·cm–2 for glucose biosensors. Such analytical performance characteristics are, most probably, achieved due to the enrichment of the diffusion layer by analyte mass transfer from the bulk upon opening of the circuit. Due to an improved sensitivity-to-background ratio, reduced flow-rate dependence, and enhanced operational stability, the regime allows reliable monitoring of blood glucose variations through sweat analysis with the on-skin device.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.2c05746</identifier><identifier>PMID: 37129422</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biosensing Techniques ; Biosensors ; Blood Glucose ; Chemistry ; Circuits ; Diabetes mellitus ; Diabetes Mellitus - diagnosis ; Diffusion layers ; Electric power generation ; Electrical measurement ; Flow stability ; Glucose ; Humans ; Hydrogen Peroxide ; Mass transfer ; Monitoring ; Pigments ; Sensitivity ; Sensors ; State power</subject><ispartof>Analytical chemistry (Washington), 2023-05, Vol.95 (19), p.7528-7535</ispartof><rights>2023 American Chemical Society</rights><rights>Copyright American Chemical Society May 16, 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a325t-f178bed8337531c8e625f100955ae1e252eab52d447dbb0d5d0c25c76a695c4b3</cites><orcidid>0000-0002-9103-9984 ; 0000-0002-3644-9673 ; 0000-0002-2851-6821</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.2c05746$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.2c05746$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56716,56766</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37129422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komkova, Maria A.</creatorcontrib><creatorcontrib>Eliseev, Artem A.</creatorcontrib><creatorcontrib>Kasimovskaya, Valeria S.</creatorcontrib><creatorcontrib>Poyarkov, Andrei A.</creatorcontrib><creatorcontrib>Eliseev, Andrei A.</creatorcontrib><creatorcontrib>Karyakin, Arkady A.</creatorcontrib><title>Pulse Power Generation Chronoamperometry as an Advanced Readout for (Bio)sensors: Application for Noninvasive Diabetes Monitoring</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>We propose pulse power generation (PPG) amperometry as an advanced readout realized for Prussian blue (PB)-based (bio)sensors. In contrast to the conventional power generation mode, when the current response is generated upon continuous short-circuiting, the suggested pulse regime is fulfilled by periodic opening and shorting of the circuit. Despite PB being electroactive, the pulse readout is advantageous over conventional steady-state power generation, providing up to a 15-fold increased signal-to-background ratio as well as dramatically improved sensitivity exceeding 10 A·M–1·cm–2 for H2O2 sensors and 3.9 A·M–1·cm–2 for glucose biosensors. Such analytical performance characteristics are, most probably, achieved due to the enrichment of the diffusion layer by analyte mass transfer from the bulk upon opening of the circuit. Due to an improved sensitivity-to-background ratio, reduced flow-rate dependence, and enhanced operational stability, the regime allows reliable monitoring of blood glucose variations through sweat analysis with the on-skin device.</description><subject>Biosensing Techniques</subject><subject>Biosensors</subject><subject>Blood Glucose</subject><subject>Chemistry</subject><subject>Circuits</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - diagnosis</subject><subject>Diffusion layers</subject><subject>Electric power generation</subject><subject>Electrical measurement</subject><subject>Flow stability</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hydrogen Peroxide</subject><subject>Mass transfer</subject><subject>Monitoring</subject><subject>Pigments</subject><subject>Sensitivity</subject><subject>Sensors</subject><subject>State power</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi1ERZeFf1AhS1zKIduxE-eD27JAqdRCheg5mtgT6iqxg50s6rH_nKx22wOHniyNn_cZyy9jJwJWAqQ4Qx1X6LDTt9SvpAZVZPkLthBKQpKXpXzJFgCQJrIAOGavY7wDEAJE_oodp4WQVSblgj1cT10kfu3_UuDn5CjgaL3jm9vgncd-oOB7GsM9x8jR8bXZotNk-E9C46eRtz7w00_Wf4jkog_xI18PQ2f1XrO7_e6ddVuMdkv8s8WGRor8ah6OPlj3-w07anF-w9vDuWQ3X7_82nxLLn-cX2zWlwmmUo1JK4qyIVOmaaFSoUvKpWoFQKUUkiCpJGGjpMmywjQNGGVAS6WLHPNK6axJl-x07x2C_zNRHOveRk1dh478FGtZQqkqyGf9kr3_D73zU5j_ekcJpaqqADFT2Z7SwccYqK2HYHsM97WAeldRPVdUP1ZUHyqaY-8O8qnpyTyFHjuZAdgDu_jT4med_wCHuaGL</recordid><startdate>20230516</startdate><enddate>20230516</enddate><creator>Komkova, Maria A.</creator><creator>Eliseev, Artem A.</creator><creator>Kasimovskaya, Valeria S.</creator><creator>Poyarkov, Andrei A.</creator><creator>Eliseev, Andrei A.</creator><creator>Karyakin, Arkady A.</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9103-9984</orcidid><orcidid>https://orcid.org/0000-0002-3644-9673</orcidid><orcidid>https://orcid.org/0000-0002-2851-6821</orcidid></search><sort><creationdate>20230516</creationdate><title>Pulse Power Generation Chronoamperometry as an Advanced Readout for (Bio)sensors: Application for Noninvasive Diabetes Monitoring</title><author>Komkova, Maria A. ; 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Chem</addtitle><date>2023-05-16</date><risdate>2023</risdate><volume>95</volume><issue>19</issue><spage>7528</spage><epage>7535</epage><pages>7528-7535</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>We propose pulse power generation (PPG) amperometry as an advanced readout realized for Prussian blue (PB)-based (bio)sensors. In contrast to the conventional power generation mode, when the current response is generated upon continuous short-circuiting, the suggested pulse regime is fulfilled by periodic opening and shorting of the circuit. Despite PB being electroactive, the pulse readout is advantageous over conventional steady-state power generation, providing up to a 15-fold increased signal-to-background ratio as well as dramatically improved sensitivity exceeding 10 A·M–1·cm–2 for H2O2 sensors and 3.9 A·M–1·cm–2 for glucose biosensors. Such analytical performance characteristics are, most probably, achieved due to the enrichment of the diffusion layer by analyte mass transfer from the bulk upon opening of the circuit. Due to an improved sensitivity-to-background ratio, reduced flow-rate dependence, and enhanced operational stability, the regime allows reliable monitoring of blood glucose variations through sweat analysis with the on-skin device.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>37129422</pmid><doi>10.1021/acs.analchem.2c05746</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-9103-9984</orcidid><orcidid>https://orcid.org/0000-0002-3644-9673</orcidid><orcidid>https://orcid.org/0000-0002-2851-6821</orcidid></addata></record> |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Biosensing Techniques Biosensors Blood Glucose Chemistry Circuits Diabetes mellitus Diabetes Mellitus - diagnosis Diffusion layers Electric power generation Electrical measurement Flow stability Glucose Humans Hydrogen Peroxide Mass transfer Monitoring Pigments Sensitivity Sensors State power |
| title | Pulse Power Generation Chronoamperometry as an Advanced Readout for (Bio)sensors: Application for Noninvasive Diabetes Monitoring |
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