Lumbrical muscle enhancement on MRI and its association with rheumatoid arthritis
Objective To investigate the significance of lumbrical muscle enhancement (LME) on magnetic resonance imaging (MRI) in rheumatoid arthritis (RA). Materials and methods Blinded to the diagnoses, contrast-enhanced bilateral hand MRIs of patients with suspected early RA between 2014 and 2019 were revie...
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| Veröffentlicht in: | Skeletal radiology 2023-10, Vol.52 (10), p.1975-1985 |
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| container_end_page | 1985 |
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| container_issue | 10 |
| container_start_page | 1975 |
| container_title | Skeletal radiology |
| container_volume | 52 |
| creator | Akkaya, Zehra Çoruh, Ayşegül Gürsoy Ünal, Sena Hürsoy, Nur Elhan, Atilla Halil Şahin, Gülden |
| description | Objective
To investigate the significance of lumbrical muscle enhancement (LME) on magnetic resonance imaging (MRI) in rheumatoid arthritis (RA).
Materials and methods
Blinded to the diagnoses, contrast-enhanced bilateral hand MRIs of patients with suspected early RA between 2014 and 2019 were reviewed by two observers for the presence and degree (weak/strong) of LME. The presence of other inflammatory findings was also noted. The patients were then stratified into RA (
n
= 41), control (
n
= 31), and other arthritides groups(
n
= 28) based on their final diagnoses in the hospital records within the following 12 months. Categorical variables were compared by chi-square test or Fisher’s exact test. Differences among the groups were evaluated by one-way ANOVA or Kruskal–Wallis tests. When the
p
-value from the Kruskal–Wallis test was statistically significant, multiple comparison test was used to identify group differences. Correlations between LME and flexor tenosynovitis were evaluated by Spearman rank correlation test. The agreement between two observers was assessed by Cohen’s Kappa (
κ
) statistic.
P
-value |
| doi_str_mv | 10.1007/s00256-023-04353-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2808588172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A762137085</galeid><sourcerecordid>A762137085</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-5d66414a93b90f3217894d950cba49a025b20a824508134ba01fb79cd07a25123</originalsourceid><addsrcrecordid>eNp9kVtrFTEUhYMo9lj9Az7IgC--TN25zzyW4qVwpLToc9iTyfSkzCQ1yVD89-Z4qkWREkhg51uLtVmEvKZwQgH0-wzApGqB8RYEl_V-QjZUcNYyquhTsgGuRMu46I7Ii5xvAKjWUj0nR1xT1ivKNuRyuy5D8hbnZlmznV3jwg6DdYsLpYmh-XJ13mAYG19ygzlH67H4Or_zZdeknVsXLNGPDaayS774_JI8m3DO7tX9e0y-ffzw9exzu734dH52um0t73lp5aiUoAJ7PvQwcUZ114uxl2AHFD3WzQYG2DEhoaNcDAh0GnRvR9DIJGX8mLw7-N6m-H11uZjFZ-vmGYOLazasg052HdV79O0_6E1cU6jpKiVrDgVUPVDXODvjwxRLQrs3NadaMcp1NazUyX-oeka3eBuDm3yd_yVgB4FNMefkJnOb_ILph6Fg9j2aQ4-m9mh-9Wigit7cJ16HxY1_JL-LqwA_ALl-hWuXHlZ6xPYnztykoA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2856646016</pqid></control><display><type>article</type><title>Lumbrical muscle enhancement on MRI and its association with rheumatoid arthritis</title><source>SpringerLink Journals - AutoHoldings</source><creator>Akkaya, Zehra ; Çoruh, Ayşegül Gürsoy ; Ünal, Sena ; Hürsoy, Nur ; Elhan, Atilla Halil ; Şahin, Gülden</creator><creatorcontrib>Akkaya, Zehra ; Çoruh, Ayşegül Gürsoy ; Ünal, Sena ; Hürsoy, Nur ; Elhan, Atilla Halil ; Şahin, Gülden</creatorcontrib><description>Objective
To investigate the significance of lumbrical muscle enhancement (LME) on magnetic resonance imaging (MRI) in rheumatoid arthritis (RA).
Materials and methods
Blinded to the diagnoses, contrast-enhanced bilateral hand MRIs of patients with suspected early RA between 2014 and 2019 were reviewed by two observers for the presence and degree (weak/strong) of LME. The presence of other inflammatory findings was also noted. The patients were then stratified into RA (
n
= 41), control (
n
= 31), and other arthritides groups(
n
= 28) based on their final diagnoses in the hospital records within the following 12 months. Categorical variables were compared by chi-square test or Fisher’s exact test. Differences among the groups were evaluated by one-way ANOVA or Kruskal–Wallis tests. When the
p
-value from the Kruskal–Wallis test was statistically significant, multiple comparison test was used to identify group differences. Correlations between LME and flexor tenosynovitis were evaluated by Spearman rank correlation test. The agreement between two observers was assessed by Cohen’s Kappa (
κ
) statistic.
P
-value < 0.05 was considered as statistically significant.
Results
There were 100 patients (88 females) with mean age of 47.2 ± 11.2. There were no significant differences for age or sex between groups (
p
= 0.17,
p
= 0.84, respectively). RA patients showed significantly more frequent (
p
< 0.001) and stronger LME (
p
= 0.001).
There were no correlations between LME and flexor tenosynovitis (
p
> 0.05). Interrater agreement for the degree of LME on right and left sides was substantial (
κ
= 0.74,
κ
= 0.67, respectively).
Conclusion
RA patients demonstrated significantly more frequent and stronger LME with substantial interrater agreement. LME could constitute a subtle radiological clue for early RA.</description><identifier>ISSN: 0364-2348</identifier><identifier>EISSN: 1432-2161</identifier><identifier>DOI: 10.1007/s00256-023-04353-0</identifier><identifier>PMID: 37129612</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Arthritis ; Chi-square test ; Comparative analysis ; Correlation ; Imaging ; Inflammation ; Kruskal-Wallis test ; Magnetic resonance imaging ; Medical records ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Muscles ; Nuclear Medicine ; Observers ; Orthopedics ; Pathology ; Radiology ; Rheumatoid arthritis ; Rheumatoid factor ; Scientific Article ; Statistical analysis ; Tenosynovitis</subject><ispartof>Skeletal radiology, 2023-10, Vol.52 (10), p.1975-1985</ispartof><rights>The Author(s), under exclusive licence to International Skeletal Society (ISS) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to International Skeletal Society (ISS).</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c393t-5d66414a93b90f3217894d950cba49a025b20a824508134ba01fb79cd07a25123</cites><orcidid>0000-0002-6483-3381</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00256-023-04353-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00256-023-04353-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37129612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akkaya, Zehra</creatorcontrib><creatorcontrib>Çoruh, Ayşegül Gürsoy</creatorcontrib><creatorcontrib>Ünal, Sena</creatorcontrib><creatorcontrib>Hürsoy, Nur</creatorcontrib><creatorcontrib>Elhan, Atilla Halil</creatorcontrib><creatorcontrib>Şahin, Gülden</creatorcontrib><title>Lumbrical muscle enhancement on MRI and its association with rheumatoid arthritis</title><title>Skeletal radiology</title><addtitle>Skeletal Radiol</addtitle><addtitle>Skeletal Radiol</addtitle><description>Objective
To investigate the significance of lumbrical muscle enhancement (LME) on magnetic resonance imaging (MRI) in rheumatoid arthritis (RA).
Materials and methods
Blinded to the diagnoses, contrast-enhanced bilateral hand MRIs of patients with suspected early RA between 2014 and 2019 were reviewed by two observers for the presence and degree (weak/strong) of LME. The presence of other inflammatory findings was also noted. The patients were then stratified into RA (
n
= 41), control (
n
= 31), and other arthritides groups(
n
= 28) based on their final diagnoses in the hospital records within the following 12 months. Categorical variables were compared by chi-square test or Fisher’s exact test. Differences among the groups were evaluated by one-way ANOVA or Kruskal–Wallis tests. When the
p
-value from the Kruskal–Wallis test was statistically significant, multiple comparison test was used to identify group differences. Correlations between LME and flexor tenosynovitis were evaluated by Spearman rank correlation test. The agreement between two observers was assessed by Cohen’s Kappa (
κ
) statistic.
P
-value < 0.05 was considered as statistically significant.
Results
There were 100 patients (88 females) with mean age of 47.2 ± 11.2. There were no significant differences for age or sex between groups (
p
= 0.17,
p
= 0.84, respectively). RA patients showed significantly more frequent (
p
< 0.001) and stronger LME (
p
= 0.001).
There were no correlations between LME and flexor tenosynovitis (
p
> 0.05). Interrater agreement for the degree of LME on right and left sides was substantial (
κ
= 0.74,
κ
= 0.67, respectively).
Conclusion
RA patients demonstrated significantly more frequent and stronger LME with substantial interrater agreement. LME could constitute a subtle radiological clue for early RA.</description><subject>Arthritis</subject><subject>Chi-square test</subject><subject>Comparative analysis</subject><subject>Correlation</subject><subject>Imaging</subject><subject>Inflammation</subject><subject>Kruskal-Wallis test</subject><subject>Magnetic resonance imaging</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Muscles</subject><subject>Nuclear Medicine</subject><subject>Observers</subject><subject>Orthopedics</subject><subject>Pathology</subject><subject>Radiology</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Scientific Article</subject><subject>Statistical analysis</subject><subject>Tenosynovitis</subject><issn>0364-2348</issn><issn>1432-2161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kVtrFTEUhYMo9lj9Az7IgC--TN25zzyW4qVwpLToc9iTyfSkzCQ1yVD89-Z4qkWREkhg51uLtVmEvKZwQgH0-wzApGqB8RYEl_V-QjZUcNYyquhTsgGuRMu46I7Ii5xvAKjWUj0nR1xT1ivKNuRyuy5D8hbnZlmznV3jwg6DdYsLpYmh-XJ13mAYG19ygzlH67H4Or_zZdeknVsXLNGPDaayS774_JI8m3DO7tX9e0y-ffzw9exzu734dH52um0t73lp5aiUoAJ7PvQwcUZ114uxl2AHFD3WzQYG2DEhoaNcDAh0GnRvR9DIJGX8mLw7-N6m-H11uZjFZ-vmGYOLazasg052HdV79O0_6E1cU6jpKiVrDgVUPVDXODvjwxRLQrs3NadaMcp1NazUyX-oeka3eBuDm3yd_yVgB4FNMefkJnOb_ILph6Fg9j2aQ4-m9mh-9Wigit7cJ16HxY1_JL-LqwA_ALl-hWuXHlZ6xPYnztykoA</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Akkaya, Zehra</creator><creator>Çoruh, Ayşegül Gürsoy</creator><creator>Ünal, Sena</creator><creator>Hürsoy, Nur</creator><creator>Elhan, Atilla Halil</creator><creator>Şahin, Gülden</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6483-3381</orcidid></search><sort><creationdate>20231001</creationdate><title>Lumbrical muscle enhancement on MRI and its association with rheumatoid arthritis</title><author>Akkaya, Zehra ; Çoruh, Ayşegül Gürsoy ; Ünal, Sena ; Hürsoy, Nur ; Elhan, Atilla Halil ; Şahin, Gülden</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-5d66414a93b90f3217894d950cba49a025b20a824508134ba01fb79cd07a25123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Arthritis</topic><topic>Chi-square test</topic><topic>Comparative analysis</topic><topic>Correlation</topic><topic>Imaging</topic><topic>Inflammation</topic><topic>Kruskal-Wallis test</topic><topic>Magnetic resonance imaging</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Muscles</topic><topic>Nuclear Medicine</topic><topic>Observers</topic><topic>Orthopedics</topic><topic>Pathology</topic><topic>Radiology</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Scientific Article</topic><topic>Statistical analysis</topic><topic>Tenosynovitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akkaya, Zehra</creatorcontrib><creatorcontrib>Çoruh, Ayşegül Gürsoy</creatorcontrib><creatorcontrib>Ünal, Sena</creatorcontrib><creatorcontrib>Hürsoy, Nur</creatorcontrib><creatorcontrib>Elhan, Atilla Halil</creatorcontrib><creatorcontrib>Şahin, Gülden</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Skeletal radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akkaya, Zehra</au><au>Çoruh, Ayşegül Gürsoy</au><au>Ünal, Sena</au><au>Hürsoy, Nur</au><au>Elhan, Atilla Halil</au><au>Şahin, Gülden</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lumbrical muscle enhancement on MRI and its association with rheumatoid arthritis</atitle><jtitle>Skeletal radiology</jtitle><stitle>Skeletal Radiol</stitle><addtitle>Skeletal Radiol</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>52</volume><issue>10</issue><spage>1975</spage><epage>1985</epage><pages>1975-1985</pages><issn>0364-2348</issn><eissn>1432-2161</eissn><abstract>Objective
To investigate the significance of lumbrical muscle enhancement (LME) on magnetic resonance imaging (MRI) in rheumatoid arthritis (RA).
Materials and methods
Blinded to the diagnoses, contrast-enhanced bilateral hand MRIs of patients with suspected early RA between 2014 and 2019 were reviewed by two observers for the presence and degree (weak/strong) of LME. The presence of other inflammatory findings was also noted. The patients were then stratified into RA (
n
= 41), control (
n
= 31), and other arthritides groups(
n
= 28) based on their final diagnoses in the hospital records within the following 12 months. Categorical variables were compared by chi-square test or Fisher’s exact test. Differences among the groups were evaluated by one-way ANOVA or Kruskal–Wallis tests. When the
p
-value from the Kruskal–Wallis test was statistically significant, multiple comparison test was used to identify group differences. Correlations between LME and flexor tenosynovitis were evaluated by Spearman rank correlation test. The agreement between two observers was assessed by Cohen’s Kappa (
κ
) statistic.
P
-value < 0.05 was considered as statistically significant.
Results
There were 100 patients (88 females) with mean age of 47.2 ± 11.2. There were no significant differences for age or sex between groups (
p
= 0.17,
p
= 0.84, respectively). RA patients showed significantly more frequent (
p
< 0.001) and stronger LME (
p
= 0.001).
There were no correlations between LME and flexor tenosynovitis (
p
> 0.05). Interrater agreement for the degree of LME on right and left sides was substantial (
κ
= 0.74,
κ
= 0.67, respectively).
Conclusion
RA patients demonstrated significantly more frequent and stronger LME with substantial interrater agreement. LME could constitute a subtle radiological clue for early RA.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37129612</pmid><doi>10.1007/s00256-023-04353-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6483-3381</orcidid></addata></record> |
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| ispartof | Skeletal radiology, 2023-10, Vol.52 (10), p.1975-1985 |
| issn | 0364-2348 1432-2161 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2808588172 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Arthritis Chi-square test Comparative analysis Correlation Imaging Inflammation Kruskal-Wallis test Magnetic resonance imaging Medical records Medical research Medicine Medicine & Public Health Medicine, Experimental Muscles Nuclear Medicine Observers Orthopedics Pathology Radiology Rheumatoid arthritis Rheumatoid factor Scientific Article Statistical analysis Tenosynovitis |
| title | Lumbrical muscle enhancement on MRI and its association with rheumatoid arthritis |
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