Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice
Patient-derived xenograft (PDX) mouse models are useful for deepening our understanding of the biology of malignant lymphoma; however, factors associated with the success of the PDX lymphoma model are largely unknown. We retrospectively analyzed the characteristics of 66 xenotransplantations from 65...
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| Veröffentlicht in: | International journal of hematology 2023-08, Vol.118 (2), p.221-230 |
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| creator | Sahashi, Satomi Shimada, Kazuyuki Takagi, Yusuke Aoki, Tomohiro Kunou, Shunsuke Sakamoto, Akihiko Murase, Atsushi Furukawa, Katsuya Kagaya, Yusuke Yamaga, Yusuke Takai, Mika Tokuyama, Kiyonobu Shimada, Satoko Nakamura, Shigeo Kiyoi, Hitoshi |
| description | Patient-derived xenograft (PDX) mouse models are useful for deepening our understanding of the biology of malignant lymphoma; however, factors associated with the success of the PDX lymphoma model are largely unknown. We retrospectively analyzed the characteristics of 66 xenotransplantations from 65 patients. In all, 43 (65%) specimens were obtained from patients aged > 60 years, and 42 (64%) specimens were obtained at diagnosis. Specimens were obtained from patients with the following diseases: diffuse large B-cell lymphoma (n = 30), intravascular large B-cell lymphoma (n = 12), follicular lymphoma (n = 8), peripheral T-cell lymphoma (n = 7), mantle cell lymphoma (n = 2), and other (n = 7). The specimens were sourced mainly from bone marrow (n = 31, 47%) and extranodal tumors (n = 13, 20%). Engraftment was successful in 33/66 (50%) xenotransplantations. The median age of patients who provided successful specimens was significantly higher than that for unsuccessful specimens (p = 0.013). Specimens with a high proportion of tumor cells in the graft and those obtained from patients with relapsed/refractory disease showed higher tendencies toward successful engraftment. Taken together, these data suggest that tumor cells with a highly malignant potential might have a high likelihood of engraftment. |
| doi_str_mv | 10.1007/s12185-023-03604-z |
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We retrospectively analyzed the characteristics of 66 xenotransplantations from 65 patients. In all, 43 (65%) specimens were obtained from patients aged > 60 years, and 42 (64%) specimens were obtained at diagnosis. Specimens were obtained from patients with the following diseases: diffuse large B-cell lymphoma (n = 30), intravascular large B-cell lymphoma (n = 12), follicular lymphoma (n = 8), peripheral T-cell lymphoma (n = 7), mantle cell lymphoma (n = 2), and other (n = 7). The specimens were sourced mainly from bone marrow (n = 31, 47%) and extranodal tumors (n = 13, 20%). Engraftment was successful in 33/66 (50%) xenotransplantations. The median age of patients who provided successful specimens was significantly higher than that for unsuccessful specimens (p = 0.013). Specimens with a high proportion of tumor cells in the graft and those obtained from patients with relapsed/refractory disease showed higher tendencies toward successful engraftment. Taken together, these data suggest that tumor cells with a highly malignant potential might have a high likelihood of engraftment.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-023-03604-z</identifier><identifier>PMID: 37129802</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Animal models ; B-cell lymphoma ; Bone marrow ; Bone tumors ; Hematology ; Lymphocytes B ; Lymphocytes T ; Lymphoma ; Mantle cell lymphoma ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Patients ; T-cell lymphoma ; Tumor cells ; Tumors ; Xenografts ; Xenotransplantation</subject><ispartof>International journal of hematology, 2023-08, Vol.118 (2), p.221-230</ispartof><rights>Japanese Society of Hematology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. 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| subjects | Animal models B-cell lymphoma Bone marrow Bone tumors Hematology Lymphocytes B Lymphocytes T Lymphoma Mantle cell lymphoma Medicine Medicine & Public Health Oncology Original Article Patients T-cell lymphoma Tumor cells Tumors Xenografts Xenotransplantation |
| title | Clinicopathological characteristics associated with the engraftment of patient lymphoma cells in NOG mice |
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