Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism is a critical factor that affects the occurrence and development of DCM. Additionally, the upregulatio...

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Veröffentlicht in:	Phytotherapy research 2023-08, Vol.37 (8), p.3543-3558
Hauptverfasser:	Wu, Shun, Lu, Dingchun, Gajendran, Babu, Hu, Qilan, Zhang, Jian, Wang, Shengquan, Han, Minzhen, Xu, Yini, Shen, Xiangchun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Aquatic plants Cardiomyocytes Cardiomyopathy Cardiovascular diseases Cell death Congestive heart failure Cytology Diabetes Diabetes mellitus diabetic cardiomyopathy Endoplasmic reticulum endoplasmic reticulum stress Gene expression Herbal medicine Metabolism mRNA Proteins Rhizomes siRNA SIRT1 SIRT1 protein tanshinone IIA Tanshinones Transfection
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