Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway

Psychiatric and cognitive impairment has been observed in premenopausal women with a hormonal disorder called polycystic ovary syndrome (PCOS). This study aimed to explore the possibility of combining pharmacological agents: Carvedilol and Clomiphene citrate, with antiestrogenic, antioxidant and ant...

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Veröffentlicht in:	Life sciences (1973) 2023-07, Vol.324, p.121737-121737, Article 121737
Hauptverfasser:	Akintoye, Olabode Oluwadare, Ajibare, Ayodeji Johnson, Oriyomi, Isaac Adeola, Olofinbiyi, Babatunde Ajayi, Yusuf, Grace Oyiza, Afuye, Damilola Christanah, Babalola, Temitope Kabirat, Faturoti, Oluwadamilola Esther, Oludipe, Seun, Owoyele, Victor Bamidele
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Animals Carvedilol Carvedilol - pharmacology Carvedilol - therapeutic use Catalase Clomiphene Clomiphene - pharmacology Clomiphene - therapeutic use Cognition Esterases Female Fertility Agents, Female - pharmacology Fertility Agents, Female - therapeutic use Humans Infertility, Female - drug therapy Letrozole - pharmacology Neurobehaviour NF-E2-Related Factor 2 NF-kappa B - drug effects NF-kappa B - metabolism Ovulation Induction PCOS Phenotype Polycystic Ovary Syndrome - metabolism Rats
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