Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review
Abstract Objectives To provide an institutional experience with cases diagnosed as carcinoma ex pleomorphic adenoma (CXPA), including the cytologic and histologic findings and clinical follow-up, followed by a comparison to the experience documented in the literature. Methods We identified cases of...
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| Veröffentlicht in: | American journal of clinical pathology 2023-05, Vol.159 (5), p.502-515 |
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| container_title | American journal of clinical pathology |
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| creator | Tondi-Resta, Isabella Hobday, Sara B Gubbiotti, Maria A Jalaly, Jalal B Rassekh, Christopher H Montone, Kathleen T Baloch, Zubair W |
| description | Abstract
Objectives
To provide an institutional experience with cases diagnosed as carcinoma ex pleomorphic adenoma (CXPA), including the cytologic and histologic findings and clinical follow-up, followed by a comparison to the experience documented in the literature.
Methods
We identified cases of CXPA diagnosed at our institution from 2011 to 2021 and reviewed the cytologic and histologic diagnoses, as well as the treatment and clinical outcomes. Additionally, a literature review of the English literature was performed on CXPAs from 2011 to 2021.
Results
Forty-one cases of CXPA were identified, with the majority subclassified as adenocarcinoma, not otherwise specified. Five tumors underwent cytogenetic studies and five underwent molecular studies. To date, 36 patients are alive, 8 of whom experienced locoregional recurrence or distant metastasis.
Conclusions
Our institutional experience was comparable to that reported in the literature. Further studies are required to inquire about the role of molecular profiles of CXPAs in clinical risk assessment. |
| doi_str_mv | 10.1093/ajcp/aqac181 |
| format | Article |
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Objectives
To provide an institutional experience with cases diagnosed as carcinoma ex pleomorphic adenoma (CXPA), including the cytologic and histologic findings and clinical follow-up, followed by a comparison to the experience documented in the literature.
Methods
We identified cases of CXPA diagnosed at our institution from 2011 to 2021 and reviewed the cytologic and histologic diagnoses, as well as the treatment and clinical outcomes. Additionally, a literature review of the English literature was performed on CXPAs from 2011 to 2021.
Results
Forty-one cases of CXPA were identified, with the majority subclassified as adenocarcinoma, not otherwise specified. Five tumors underwent cytogenetic studies and five underwent molecular studies. To date, 36 patients are alive, 8 of whom experienced locoregional recurrence or distant metastasis.
Conclusions
Our institutional experience was comparable to that reported in the literature. Further studies are required to inquire about the role of molecular profiles of CXPAs in clinical risk assessment.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/aqac181</identifier><identifier>PMID: 36921078</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adenocarcinoma ; Adenocarcinoma - pathology ; Adenoma ; Adenoma, Pleomorphic - pathology ; Analysis ; Cancer ; Carcinoma ; Cytogenetics ; Humans ; Literature reviews ; Medical research ; Medicine, Experimental ; Metastases ; Neoplasm Recurrence, Local ; Risk assessment ; Salivary Gland Neoplasms - pathology</subject><ispartof>American journal of clinical pathology, 2023-05, Vol.159 (5), p.502-515</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><rights>COPYRIGHT 2023 Oxford University Press</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-e4d0a4cf778b604779c8a7f2728177560396a7e6725e0585e3be0a5b67188e1f3</citedby><cites>FETCH-LOGICAL-c418t-e4d0a4cf778b604779c8a7f2728177560396a7e6725e0585e3be0a5b67188e1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36921078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tondi-Resta, Isabella</creatorcontrib><creatorcontrib>Hobday, Sara B</creatorcontrib><creatorcontrib>Gubbiotti, Maria A</creatorcontrib><creatorcontrib>Jalaly, Jalal B</creatorcontrib><creatorcontrib>Rassekh, Christopher H</creatorcontrib><creatorcontrib>Montone, Kathleen T</creatorcontrib><creatorcontrib>Baloch, Zubair W</creatorcontrib><title>Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>Abstract
Objectives
To provide an institutional experience with cases diagnosed as carcinoma ex pleomorphic adenoma (CXPA), including the cytologic and histologic findings and clinical follow-up, followed by a comparison to the experience documented in the literature.
Methods
We identified cases of CXPA diagnosed at our institution from 2011 to 2021 and reviewed the cytologic and histologic diagnoses, as well as the treatment and clinical outcomes. Additionally, a literature review of the English literature was performed on CXPAs from 2011 to 2021.
Results
Forty-one cases of CXPA were identified, with the majority subclassified as adenocarcinoma, not otherwise specified. Five tumors underwent cytogenetic studies and five underwent molecular studies. To date, 36 patients are alive, 8 of whom experienced locoregional recurrence or distant metastasis.
Conclusions
Our institutional experience was comparable to that reported in the literature. Further studies are required to inquire about the role of molecular profiles of CXPAs in clinical risk assessment.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenoma</subject><subject>Adenoma, Pleomorphic - pathology</subject><subject>Analysis</subject><subject>Cancer</subject><subject>Carcinoma</subject><subject>Cytogenetics</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metastases</subject><subject>Neoplasm Recurrence, Local</subject><subject>Risk assessment</subject><subject>Salivary Gland Neoplasms - pathology</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90UFrFDEUB_BQKnat3nouAz3Ug9MmmWSS6W1ZqhYWFKnn8DbzxmaZSabJTNVvb5ZdFUUkh8Dj917y-BNyxugVo011DVs7XsMjWKbZEVmwRlSlUpwfkwWllJcNU9UJeZHSllLGNRXPyUlVN5xRpRfkfgXROh8GKG6_FR97DEOI44OzxbLFXTndFEtf3Pk0uWmeXPDQZzlidOgtFuDbYu0mjDDNEYtP-OTw60vyrIM-4avDfUo-v729X70v1x_e3a2W69IKpqcSRUtB2E4pvampUKqxGlTHFddMKVnTqqlBYa24RCq1xGqDFOSmVkxrZF11Sl7v544xPM6YJjO4ZLHvwWOYk8nbaqlFo1mmF3_RbZhjXiarRkrOpZDyt_oCPRrnuzBFsLuhZqlkfpbxWmR19Q-VT4uDs8Fj53L9j4Y3-wYbQ0oROzNGN0D8bhg1uxDNLkRzCDHz88Nf582A7S_8M7UMLvcgzOP_R_0Aa0KjOA</recordid><startdate>20230502</startdate><enddate>20230502</enddate><creator>Tondi-Resta, Isabella</creator><creator>Hobday, Sara B</creator><creator>Gubbiotti, Maria A</creator><creator>Jalaly, Jalal B</creator><creator>Rassekh, Christopher H</creator><creator>Montone, Kathleen T</creator><creator>Baloch, Zubair W</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20230502</creationdate><title>Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review</title><author>Tondi-Resta, Isabella ; Hobday, Sara B ; Gubbiotti, Maria A ; Jalaly, Jalal B ; Rassekh, Christopher H ; Montone, Kathleen T ; Baloch, Zubair W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e4d0a4cf778b604779c8a7f2728177560396a7e6725e0585e3be0a5b67188e1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenoma</topic><topic>Adenoma, Pleomorphic - pathology</topic><topic>Analysis</topic><topic>Cancer</topic><topic>Carcinoma</topic><topic>Cytogenetics</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metastases</topic><topic>Neoplasm Recurrence, Local</topic><topic>Risk assessment</topic><topic>Salivary Gland Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tondi-Resta, Isabella</creatorcontrib><creatorcontrib>Hobday, Sara B</creatorcontrib><creatorcontrib>Gubbiotti, Maria A</creatorcontrib><creatorcontrib>Jalaly, Jalal B</creatorcontrib><creatorcontrib>Rassekh, Christopher H</creatorcontrib><creatorcontrib>Montone, Kathleen T</creatorcontrib><creatorcontrib>Baloch, Zubair W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tondi-Resta, Isabella</au><au>Hobday, Sara B</au><au>Gubbiotti, Maria A</au><au>Jalaly, Jalal B</au><au>Rassekh, Christopher H</au><au>Montone, Kathleen T</au><au>Baloch, Zubair W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>2023-05-02</date><risdate>2023</risdate><volume>159</volume><issue>5</issue><spage>502</spage><epage>515</epage><pages>502-515</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>Abstract
Objectives
To provide an institutional experience with cases diagnosed as carcinoma ex pleomorphic adenoma (CXPA), including the cytologic and histologic findings and clinical follow-up, followed by a comparison to the experience documented in the literature.
Methods
We identified cases of CXPA diagnosed at our institution from 2011 to 2021 and reviewed the cytologic and histologic diagnoses, as well as the treatment and clinical outcomes. Additionally, a literature review of the English literature was performed on CXPAs from 2011 to 2021.
Results
Forty-one cases of CXPA were identified, with the majority subclassified as adenocarcinoma, not otherwise specified. Five tumors underwent cytogenetic studies and five underwent molecular studies. To date, 36 patients are alive, 8 of whom experienced locoregional recurrence or distant metastasis.
Conclusions
Our institutional experience was comparable to that reported in the literature. Further studies are required to inquire about the role of molecular profiles of CXPAs in clinical risk assessment.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36921078</pmid><doi>10.1093/ajcp/aqac181</doi><tpages>14</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Current; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma Adenocarcinoma - pathology Adenoma Adenoma, Pleomorphic - pathology Analysis Cancer Carcinoma Cytogenetics Humans Literature reviews Medical research Medicine, Experimental Metastases Neoplasm Recurrence, Local Risk assessment Salivary Gland Neoplasms - pathology |
| title | Carcinoma Ex Pleomorphic Adenomas: An Institutional Experience and Literature Review |
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