Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study
We conducted a two-year inhalation study of butyl methacrylate using F344/DuCrlCrlj rats and B6D2F1/Crl mice. Rats were exposed to 0, 30, 125 and 500 ppm (v/v) and mice were exposed to 0, 8, 30 and 125 ppm (v/v) using whole-body inhalation chambers. Non-neoplastic lesions developed in the nasal cavi...
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| Veröffentlicht in: | Journal of toxicological sciences 2023, Vol.48(5), pp.227-241 |
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| creator | Furukawa, Yusuke Hirai, Shigeyuki Kasai, Tatsuya Senoh, Hideki Takanobu, Kenji Sasaki, Toshiaki Kano, Hirokazu Matsumoto, Michiharu Aiso, Shigetoshi |
| description | We conducted a two-year inhalation study of butyl methacrylate using F344/DuCrlCrlj rats and B6D2F1/Crl mice. Rats were exposed to 0, 30, 125 and 500 ppm (v/v) and mice were exposed to 0, 8, 30 and 125 ppm (v/v) using whole-body inhalation chambers. Non-neoplastic lesions developed in the nasal cavities of both rats and mice, but neoplastic lesions were not found. There was also a positive trend in the incidence of large granular lymphocytic (LGL) leukemia in the spleen of male rats. No changes were observed in female rats. Overall, there is some evidence of carcinogenicity in male rats, but there is no evidence of carcinogenicity in female rats. In male mice, there was a positive trend by Peto’s test in the incidence of hepatocellular adenomas, and the incidence of hepatocellular adenomas and hepatocellular carcinomas combined was significantly increased compared to the controls by Fisher’s exact test in the 30 ppm exposed male group. In female mice, the incidence of hemangiosarcoma in all organs combined showed a positive trend by Peto’s test. Therefore, there is some evidence of carcinogenicity in male mice, and there is equivocal evidence of carcinogenicity in female mice. |
| doi_str_mv | 10.2131/jts.48.227 |
| format | Article |
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Rats were exposed to 0, 30, 125 and 500 ppm (v/v) and mice were exposed to 0, 8, 30 and 125 ppm (v/v) using whole-body inhalation chambers. Non-neoplastic lesions developed in the nasal cavities of both rats and mice, but neoplastic lesions were not found. There was also a positive trend in the incidence of large granular lymphocytic (LGL) leukemia in the spleen of male rats. No changes were observed in female rats. Overall, there is some evidence of carcinogenicity in male rats, but there is no evidence of carcinogenicity in female rats. In male mice, there was a positive trend by Peto’s test in the incidence of hepatocellular adenomas, and the incidence of hepatocellular adenomas and hepatocellular carcinomas combined was significantly increased compared to the controls by Fisher’s exact test in the 30 ppm exposed male group. In female mice, the incidence of hemangiosarcoma in all organs combined showed a positive trend by Peto’s test. Therefore, there is some evidence of carcinogenicity in male mice, and there is equivocal evidence of carcinogenicity in female mice.</description><identifier>ISSN: 0388-1350</identifier><identifier>EISSN: 1880-3989</identifier><identifier>DOI: 10.2131/jts.48.227</identifier><identifier>PMID: 37121738</identifier><language>eng</language><publisher>Japan: The Japanese Society of Toxicology</publisher><subject>2-year whole-body inhalation study ; Adenoma ; Adenoma, Liver Cell ; Animals ; Butyl methacrylate ; Carcinogenicity ; Carcinogenicity Tests ; Carcinogens ; Chronic toxicity ; Exposure ; Female ; Females ; Hepatocellular carcinoma ; Inhalation ; Lesions ; Leukemia ; Liver Neoplasms - pathology ; Male ; Males ; Mice ; Mice, Inbred Strains ; Rats ; Rats, Inbred F344 ; Respiration ; Toxicity ; Tumors</subject><ispartof>The Journal of Toxicological Sciences, 2023, Vol.48(5), pp.227-241</ispartof><rights>2023 The Japanese Society of Toxicology</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c538t-75bb05dc38b7be15b5af8f4922947ae65d3fe9f1010cf1dd14412d0e7233f5603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37121738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furukawa, Yusuke</creatorcontrib><creatorcontrib>Hirai, Shigeyuki</creatorcontrib><creatorcontrib>Kasai, Tatsuya</creatorcontrib><creatorcontrib>Senoh, Hideki</creatorcontrib><creatorcontrib>Takanobu, Kenji</creatorcontrib><creatorcontrib>Sasaki, Toshiaki</creatorcontrib><creatorcontrib>Kano, Hirokazu</creatorcontrib><creatorcontrib>Matsumoto, Michiharu</creatorcontrib><creatorcontrib>Aiso, Shigetoshi</creatorcontrib><title>Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study</title><title>Journal of toxicological sciences</title><addtitle>J Toxicol Sci</addtitle><description>We conducted a two-year inhalation study of butyl methacrylate using F344/DuCrlCrlj rats and B6D2F1/Crl mice. Rats were exposed to 0, 30, 125 and 500 ppm (v/v) and mice were exposed to 0, 8, 30 and 125 ppm (v/v) using whole-body inhalation chambers. Non-neoplastic lesions developed in the nasal cavities of both rats and mice, but neoplastic lesions were not found. There was also a positive trend in the incidence of large granular lymphocytic (LGL) leukemia in the spleen of male rats. No changes were observed in female rats. Overall, there is some evidence of carcinogenicity in male rats, but there is no evidence of carcinogenicity in female rats. In male mice, there was a positive trend by Peto’s test in the incidence of hepatocellular adenomas, and the incidence of hepatocellular adenomas and hepatocellular carcinomas combined was significantly increased compared to the controls by Fisher’s exact test in the 30 ppm exposed male group. In female mice, the incidence of hemangiosarcoma in all organs combined showed a positive trend by Peto’s test. Therefore, there is some evidence of carcinogenicity in male mice, and there is equivocal evidence of carcinogenicity in female mice.</description><subject>2-year whole-body inhalation study</subject><subject>Adenoma</subject><subject>Adenoma, Liver Cell</subject><subject>Animals</subject><subject>Butyl methacrylate</subject><subject>Carcinogenicity</subject><subject>Carcinogenicity Tests</subject><subject>Carcinogens</subject><subject>Chronic toxicity</subject><subject>Exposure</subject><subject>Female</subject><subject>Females</subject><subject>Hepatocellular carcinoma</subject><subject>Inhalation</subject><subject>Lesions</subject><subject>Leukemia</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Males</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Respiration</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>0388-1350</issn><issn>1880-3989</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1P5CAYB3CycbOOLxc_gCHxsjHpyEux9ODBTFbdZJK9rGdC6YND0xYFGu23F51xDp4I8Hv-gedB6IySJaOcXnUpLku5ZKz6gRZUSlLwWtYHaEG4lAXlghyioxg7QlhFRPkLHfKKMlpxuUDdSgfjRv8EozMuzViPLTab4PMWJ_-2PfQWN1OaezxA2mgT5l4nwG7EQaf4WTI4A7jJ5Ti9-mIGHfL1Rmfn_Ihjmtr5BP20uo9wuluP0ePdn_-rh2L97_7v6nZdGMFlKirRNES0hsumaoCKRmgrbVkzVpeVhmvRcgu1pYQSY2nb0rKkrCVQMc6tuCb8GP3e5j4H_zJBTGpw0UDf6xH8FBWTRDIq8vczvfhGOz-FMb8uKyZytzgts7rcKhN8jAGseg5u0GFWlKiPCag8AVVKlSeQ8fkucmoGaPf0q-UZ3GxBF5N-gj3QITnTw1eW2AXuz81GBwUjfwdpm5hB</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Furukawa, Yusuke</creator><creator>Hirai, Shigeyuki</creator><creator>Kasai, Tatsuya</creator><creator>Senoh, Hideki</creator><creator>Takanobu, Kenji</creator><creator>Sasaki, Toshiaki</creator><creator>Kano, Hirokazu</creator><creator>Matsumoto, Michiharu</creator><creator>Aiso, Shigetoshi</creator><general>The Japanese Society of Toxicology</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20230101</creationdate><title>Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study</title><author>Furukawa, Yusuke ; Hirai, Shigeyuki ; Kasai, Tatsuya ; Senoh, Hideki ; Takanobu, Kenji ; Sasaki, Toshiaki ; Kano, Hirokazu ; Matsumoto, Michiharu ; Aiso, Shigetoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-75bb05dc38b7be15b5af8f4922947ae65d3fe9f1010cf1dd14412d0e7233f5603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>2-year whole-body inhalation study</topic><topic>Adenoma</topic><topic>Adenoma, Liver Cell</topic><topic>Animals</topic><topic>Butyl methacrylate</topic><topic>Carcinogenicity</topic><topic>Carcinogenicity Tests</topic><topic>Carcinogens</topic><topic>Chronic toxicity</topic><topic>Exposure</topic><topic>Female</topic><topic>Females</topic><topic>Hepatocellular carcinoma</topic><topic>Inhalation</topic><topic>Lesions</topic><topic>Leukemia</topic><topic>Liver Neoplasms - pathology</topic><topic>Male</topic><topic>Males</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Respiration</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>Furukawa, Yusuke</creatorcontrib><creatorcontrib>Hirai, Shigeyuki</creatorcontrib><creatorcontrib>Kasai, Tatsuya</creatorcontrib><creatorcontrib>Senoh, Hideki</creatorcontrib><creatorcontrib>Takanobu, Kenji</creatorcontrib><creatorcontrib>Sasaki, Toshiaki</creatorcontrib><creatorcontrib>Kano, Hirokazu</creatorcontrib><creatorcontrib>Matsumoto, Michiharu</creatorcontrib><creatorcontrib>Aiso, Shigetoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of toxicological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furukawa, Yusuke</au><au>Hirai, Shigeyuki</au><au>Kasai, Tatsuya</au><au>Senoh, Hideki</au><au>Takanobu, Kenji</au><au>Sasaki, Toshiaki</au><au>Kano, Hirokazu</au><au>Matsumoto, Michiharu</au><au>Aiso, Shigetoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study</atitle><jtitle>Journal of toxicological sciences</jtitle><addtitle>J Toxicol Sci</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>48</volume><issue>5</issue><spage>227</spage><epage>241</epage><pages>227-241</pages><issn>0388-1350</issn><eissn>1880-3989</eissn><abstract>We conducted a two-year inhalation study of butyl methacrylate using F344/DuCrlCrlj rats and B6D2F1/Crl mice. Rats were exposed to 0, 30, 125 and 500 ppm (v/v) and mice were exposed to 0, 8, 30 and 125 ppm (v/v) using whole-body inhalation chambers. Non-neoplastic lesions developed in the nasal cavities of both rats and mice, but neoplastic lesions were not found. There was also a positive trend in the incidence of large granular lymphocytic (LGL) leukemia in the spleen of male rats. No changes were observed in female rats. Overall, there is some evidence of carcinogenicity in male rats, but there is no evidence of carcinogenicity in female rats. In male mice, there was a positive trend by Peto’s test in the incidence of hepatocellular adenomas, and the incidence of hepatocellular adenomas and hepatocellular carcinomas combined was significantly increased compared to the controls by Fisher’s exact test in the 30 ppm exposed male group. In female mice, the incidence of hemangiosarcoma in all organs combined showed a positive trend by Peto’s test. 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| subjects | 2-year whole-body inhalation study Adenoma Adenoma, Liver Cell Animals Butyl methacrylate Carcinogenicity Carcinogenicity Tests Carcinogens Chronic toxicity Exposure Female Females Hepatocellular carcinoma Inhalation Lesions Leukemia Liver Neoplasms - pathology Male Males Mice Mice, Inbred Strains Rats Rats, Inbred F344 Respiration Toxicity Tumors |
| title | Carcinogenicity and chronic toxicity of butyl methacrylate in rats and mice by a two-year inhalation study |
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