A new risk score for the assessment of outcomes for Chinese patients with peripartum cardiomyopathy
•A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations.•A risk score that consists of pulmonary arterial hypertension, lower hemoglobin and worse LVEF could help...
Gespeichert in:
| Veröffentlicht in: | Heart & lung 2023-07, Vol.60, p.81-86 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 86 |
|---|---|
| container_issue | |
| container_start_page | 81 |
| container_title | Heart & lung |
| container_volume | 60 |
| creator | Zhang, Ziguan Zheng, Wuyang Chen, Minwei Xie, Qiang Huang, Meirong Li, Weihua Huang, Zhengrong |
| description | •A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations.•A risk score that consists of pulmonary arterial hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.•PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay.
Peripartum cardiomyopathy (PPCM) is a potentially life-threatening complication of pregnancy, but identifying patients at higher risk of this condition remains difficult.
We conducted a study to identify new risk factors associated with PPCM and predictors of poor outcomes.
This retrospective analysis included a total of 44 women with PPCM. As a control group, 79 women who gave birth around the same time as the PPCM patients and who did not have organic disease were included. A multivariate regression analysis was conducted to identify risk factors associated with PPCM and with delayed recovery.
All PPCM patients were discharged within 28 days. In comparison to the control group, PPCM patients had higher rates of preeclampsia (20.4% vs. 1.27%, P |
| doi_str_mv | 10.1016/j.hrtlng.2023.02.021 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2808212473</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0147956323000511</els_id><sourcerecordid>2808212473</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-c99c38d058e52a1734c5685927e7ea0c257fa5323e0bb1fd4d7343f2a57c188d3</originalsourceid><addsrcrecordid>eNp9kE1P3DAQQK2qVdkC_wAhH3vJ1h9x7FwqoRW0lZC40LPldSaNl00cPA5o_z2mSzl2NNIc5s2M5hFywdmaM958262HlPfTn7VgQq6ZKMk_kBVXQldSGPORrBivddWqRp6QL4g7VkI2-jM5kU0rC6NXxF_RCZ5pCvhA0ccEtI-J5gGoQwTEEaZMY0_jkn0cAf-2N0OYAIHOLofSR_oc8kBnSGF2KS8j9S51IY6HWIjhcEY-9W6PcP5WT8nvm-v7zc_q9u7Hr83VbeVrZnLl29ZL0zFlQAnHtay9aoxqhQYNjnmhdO-UFBLYdsv7ru4KInvhlPbcmE6ekq_HvXOKjwtgtmNAD_u9myAuaIVhRnBRa1nQ-oj6FBET9HZOYXTpYDmzr3rtzh712le9lomSvIxdvl1YtiN070P_fBbg-xGA8udTgGTRF0UeupDAZ9vF8P8LL5rJjq4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2808212473</pqid></control><display><type>article</type><title>A new risk score for the assessment of outcomes for Chinese patients with peripartum cardiomyopathy</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Zhang, Ziguan ; Zheng, Wuyang ; Chen, Minwei ; Xie, Qiang ; Huang, Meirong ; Li, Weihua ; Huang, Zhengrong</creator><creatorcontrib>Zhang, Ziguan ; Zheng, Wuyang ; Chen, Minwei ; Xie, Qiang ; Huang, Meirong ; Li, Weihua ; Huang, Zhengrong</creatorcontrib><description>•A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations.•A risk score that consists of pulmonary arterial hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.•PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay.
Peripartum cardiomyopathy (PPCM) is a potentially life-threatening complication of pregnancy, but identifying patients at higher risk of this condition remains difficult.
We conducted a study to identify new risk factors associated with PPCM and predictors of poor outcomes.
This retrospective analysis included a total of 44 women with PPCM. As a control group, 79 women who gave birth around the same time as the PPCM patients and who did not have organic disease were included. A multivariate regression analysis was conducted to identify risk factors associated with PPCM and with delayed recovery.
All PPCM patients were discharged within 28 days. In comparison to the control group, PPCM patients had higher rates of preeclampsia (20.4% vs. 1.27%, P<0.001), autoimmune disease (27.3% vs. 11.4%, P = 0.018), and cesarean delivery with preterm labor (31.8% vs. 17.7%, P = 0.037). The neonates of PPCM patients had lower birth weight (2.70±0.66 kg vs. 3.21±0.57 kg, P<0.001). PPCM patients had higher levels of C-reactive protein, d-dimer, brain natriuretic peptide (BNP), and serum phosphorus, but lower levels of albumin and serum calcium (all P<0.001). In all patients with PPCM, the left ventricular ejection fraction (LVEF) returned to normal (≥50%) within 28 days after admission. Subjects with early recovery (n = 34) had lower BNP than those with delayed recovery (n = 10) (649.7 ± 526.0 pg/mL vs. 1444.1 ± 1040.8 pg/mL, P = 0.002). Multivariate regression led to a three-point score system to predict PPCM (1 point each for the presence of pericardial effusion, left ventricular dilatation, and d-dimer level ≥0.5 μg/mL). At a cutoff of ≥2, this scoring system predicted delayed recovery with 95.5% sensitivity and 96.1% specificity. The negative predictive value was 97.4% and the positive predictive value was 93.3%. Binary logistic regression indicated that PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay (minimum 14 days).
A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations. Moreover, a risk score that consists of pulmonary hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.</description><identifier>ISSN: 0147-9563</identifier><identifier>ISSN: 1527-3288</identifier><identifier>EISSN: 1527-3288</identifier><identifier>DOI: 10.1016/j.hrtlng.2023.02.021</identifier><identifier>PMID: 36933287</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cardiomyopathies - complications ; Cardiomyopathies - diagnosis ; Cardiomyopathies - epidemiology ; East Asian People ; Female ; Humans ; Hypertension, Pulmonary - complications ; Infant, Newborn ; Outcomes ; Pericardial Effusion - complications ; Peripartum cardiomyopathy ; Peripartum Period ; Pregnancy ; Prognostic factors ; Puerperal Disorders - diagnosis ; Retrospective Studies ; Risk Factors ; Risk score ; Stroke Volume ; Ventricular Function, Left</subject><ispartof>Heart & lung, 2023-07, Vol.60, p.81-86</ispartof><rights>2023 The Authors</rights><rights>Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-c99c38d058e52a1734c5685927e7ea0c257fa5323e0bb1fd4d7343f2a57c188d3</citedby><cites>FETCH-LOGICAL-c408t-c99c38d058e52a1734c5685927e7ea0c257fa5323e0bb1fd4d7343f2a57c188d3</cites><orcidid>0000-0003-3263-4828</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.hrtlng.2023.02.021$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36933287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Ziguan</creatorcontrib><creatorcontrib>Zheng, Wuyang</creatorcontrib><creatorcontrib>Chen, Minwei</creatorcontrib><creatorcontrib>Xie, Qiang</creatorcontrib><creatorcontrib>Huang, Meirong</creatorcontrib><creatorcontrib>Li, Weihua</creatorcontrib><creatorcontrib>Huang, Zhengrong</creatorcontrib><title>A new risk score for the assessment of outcomes for Chinese patients with peripartum cardiomyopathy</title><title>Heart & lung</title><addtitle>Heart Lung</addtitle><description>•A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations.•A risk score that consists of pulmonary arterial hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.•PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay.
Peripartum cardiomyopathy (PPCM) is a potentially life-threatening complication of pregnancy, but identifying patients at higher risk of this condition remains difficult.
We conducted a study to identify new risk factors associated with PPCM and predictors of poor outcomes.
This retrospective analysis included a total of 44 women with PPCM. As a control group, 79 women who gave birth around the same time as the PPCM patients and who did not have organic disease were included. A multivariate regression analysis was conducted to identify risk factors associated with PPCM and with delayed recovery.
All PPCM patients were discharged within 28 days. In comparison to the control group, PPCM patients had higher rates of preeclampsia (20.4% vs. 1.27%, P<0.001), autoimmune disease (27.3% vs. 11.4%, P = 0.018), and cesarean delivery with preterm labor (31.8% vs. 17.7%, P = 0.037). The neonates of PPCM patients had lower birth weight (2.70±0.66 kg vs. 3.21±0.57 kg, P<0.001). PPCM patients had higher levels of C-reactive protein, d-dimer, brain natriuretic peptide (BNP), and serum phosphorus, but lower levels of albumin and serum calcium (all P<0.001). In all patients with PPCM, the left ventricular ejection fraction (LVEF) returned to normal (≥50%) within 28 days after admission. Subjects with early recovery (n = 34) had lower BNP than those with delayed recovery (n = 10) (649.7 ± 526.0 pg/mL vs. 1444.1 ± 1040.8 pg/mL, P = 0.002). Multivariate regression led to a three-point score system to predict PPCM (1 point each for the presence of pericardial effusion, left ventricular dilatation, and d-dimer level ≥0.5 μg/mL). At a cutoff of ≥2, this scoring system predicted delayed recovery with 95.5% sensitivity and 96.1% specificity. The negative predictive value was 97.4% and the positive predictive value was 93.3%. Binary logistic regression indicated that PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay (minimum 14 days).
A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations. Moreover, a risk score that consists of pulmonary hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.</description><subject>Cardiomyopathies - complications</subject><subject>Cardiomyopathies - diagnosis</subject><subject>Cardiomyopathies - epidemiology</subject><subject>East Asian People</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Infant, Newborn</subject><subject>Outcomes</subject><subject>Pericardial Effusion - complications</subject><subject>Peripartum cardiomyopathy</subject><subject>Peripartum Period</subject><subject>Pregnancy</subject><subject>Prognostic factors</subject><subject>Puerperal Disorders - diagnosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Risk score</subject><subject>Stroke Volume</subject><subject>Ventricular Function, Left</subject><issn>0147-9563</issn><issn>1527-3288</issn><issn>1527-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQQK2qVdkC_wAhH3vJ1h9x7FwqoRW0lZC40LPldSaNl00cPA5o_z2mSzl2NNIc5s2M5hFywdmaM958262HlPfTn7VgQq6ZKMk_kBVXQldSGPORrBivddWqRp6QL4g7VkI2-jM5kU0rC6NXxF_RCZ5pCvhA0ccEtI-J5gGoQwTEEaZMY0_jkn0cAf-2N0OYAIHOLofSR_oc8kBnSGF2KS8j9S51IY6HWIjhcEY-9W6PcP5WT8nvm-v7zc_q9u7Hr83VbeVrZnLl29ZL0zFlQAnHtay9aoxqhQYNjnmhdO-UFBLYdsv7ru4KInvhlPbcmE6ekq_HvXOKjwtgtmNAD_u9myAuaIVhRnBRa1nQ-oj6FBET9HZOYXTpYDmzr3rtzh712le9lomSvIxdvl1YtiN070P_fBbg-xGA8udTgGTRF0UeupDAZ9vF8P8LL5rJjq4</recordid><startdate>202307</startdate><enddate>202307</enddate><creator>Zhang, Ziguan</creator><creator>Zheng, Wuyang</creator><creator>Chen, Minwei</creator><creator>Xie, Qiang</creator><creator>Huang, Meirong</creator><creator>Li, Weihua</creator><creator>Huang, Zhengrong</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3263-4828</orcidid></search><sort><creationdate>202307</creationdate><title>A new risk score for the assessment of outcomes for Chinese patients with peripartum cardiomyopathy</title><author>Zhang, Ziguan ; Zheng, Wuyang ; Chen, Minwei ; Xie, Qiang ; Huang, Meirong ; Li, Weihua ; Huang, Zhengrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-c99c38d058e52a1734c5685927e7ea0c257fa5323e0bb1fd4d7343f2a57c188d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiomyopathies - complications</topic><topic>Cardiomyopathies - diagnosis</topic><topic>Cardiomyopathies - epidemiology</topic><topic>East Asian People</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Infant, Newborn</topic><topic>Outcomes</topic><topic>Pericardial Effusion - complications</topic><topic>Peripartum cardiomyopathy</topic><topic>Peripartum Period</topic><topic>Pregnancy</topic><topic>Prognostic factors</topic><topic>Puerperal Disorders - diagnosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Risk score</topic><topic>Stroke Volume</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Ziguan</creatorcontrib><creatorcontrib>Zheng, Wuyang</creatorcontrib><creatorcontrib>Chen, Minwei</creatorcontrib><creatorcontrib>Xie, Qiang</creatorcontrib><creatorcontrib>Huang, Meirong</creatorcontrib><creatorcontrib>Li, Weihua</creatorcontrib><creatorcontrib>Huang, Zhengrong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart & lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Ziguan</au><au>Zheng, Wuyang</au><au>Chen, Minwei</au><au>Xie, Qiang</au><au>Huang, Meirong</au><au>Li, Weihua</au><au>Huang, Zhengrong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new risk score for the assessment of outcomes for Chinese patients with peripartum cardiomyopathy</atitle><jtitle>Heart & lung</jtitle><addtitle>Heart Lung</addtitle><date>2023-07</date><risdate>2023</risdate><volume>60</volume><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>0147-9563</issn><issn>1527-3288</issn><eissn>1527-3288</eissn><abstract>•A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations.•A risk score that consists of pulmonary arterial hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.•PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay.
Peripartum cardiomyopathy (PPCM) is a potentially life-threatening complication of pregnancy, but identifying patients at higher risk of this condition remains difficult.
We conducted a study to identify new risk factors associated with PPCM and predictors of poor outcomes.
This retrospective analysis included a total of 44 women with PPCM. As a control group, 79 women who gave birth around the same time as the PPCM patients and who did not have organic disease were included. A multivariate regression analysis was conducted to identify risk factors associated with PPCM and with delayed recovery.
All PPCM patients were discharged within 28 days. In comparison to the control group, PPCM patients had higher rates of preeclampsia (20.4% vs. 1.27%, P<0.001), autoimmune disease (27.3% vs. 11.4%, P = 0.018), and cesarean delivery with preterm labor (31.8% vs. 17.7%, P = 0.037). The neonates of PPCM patients had lower birth weight (2.70±0.66 kg vs. 3.21±0.57 kg, P<0.001). PPCM patients had higher levels of C-reactive protein, d-dimer, brain natriuretic peptide (BNP), and serum phosphorus, but lower levels of albumin and serum calcium (all P<0.001). In all patients with PPCM, the left ventricular ejection fraction (LVEF) returned to normal (≥50%) within 28 days after admission. Subjects with early recovery (n = 34) had lower BNP than those with delayed recovery (n = 10) (649.7 ± 526.0 pg/mL vs. 1444.1 ± 1040.8 pg/mL, P = 0.002). Multivariate regression led to a three-point score system to predict PPCM (1 point each for the presence of pericardial effusion, left ventricular dilatation, and d-dimer level ≥0.5 μg/mL). At a cutoff of ≥2, this scoring system predicted delayed recovery with 95.5% sensitivity and 96.1% specificity. The negative predictive value was 97.4% and the positive predictive value was 93.3%. Binary logistic regression indicated that PPCM patients with pulmonary hypertension, lower hemoglobin, or worse LVEF tended to require longer hospital stay (minimum 14 days).
A risk score that consists of pericardial effusion, left ventricular dilatation, and d-dimer level ≥ 0.5 μg/mL could help streamline the diagnosis of PPCM prior to confirmatory investigations. Moreover, a risk score that consists of pulmonary hypertension, lower hemoglobin and worse LVEF could help to predict poor outcomes in PPCM patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>36933287</pmid><doi>10.1016/j.hrtlng.2023.02.021</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-3263-4828</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-9563 |
| ispartof | Heart & lung, 2023-07, Vol.60, p.81-86 |
| issn | 0147-9563 1527-3288 1527-3288 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2808212473 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Cardiomyopathies - complications Cardiomyopathies - diagnosis Cardiomyopathies - epidemiology East Asian People Female Humans Hypertension, Pulmonary - complications Infant, Newborn Outcomes Pericardial Effusion - complications Peripartum cardiomyopathy Peripartum Period Pregnancy Prognostic factors Puerperal Disorders - diagnosis Retrospective Studies Risk Factors Risk score Stroke Volume Ventricular Function, Left |
| title | A new risk score for the assessment of outcomes for Chinese patients with peripartum cardiomyopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T00%3A53%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20new%20risk%20score%20for%20the%20assessment%20of%20outcomes%20for%20Chinese%20patients%20with%20peripartum%20cardiomyopathy&rft.jtitle=Heart%20&%20lung&rft.au=Zhang,%20Ziguan&rft.date=2023-07&rft.volume=60&rft.spage=81&rft.epage=86&rft.pages=81-86&rft.issn=0147-9563&rft.eissn=1527-3288&rft_id=info:doi/10.1016/j.hrtlng.2023.02.021&rft_dat=%3Cproquest_cross%3E2808212473%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2808212473&rft_id=info:pmid/36933287&rft_els_id=S0147956323000511&rfr_iscdi=true |