Chemoproteomics Reveals the Pan-HER Kinase Inhibitor Neratinib To Target an Arabidopsis Epoxide Hydrolase Related to Phytohormone Signaling

Plant phytohormone pathways are regulated by an intricate network of signaling components and modulators, many of which still remain unknown. Here, we report a forward chemical genetics approach for the identification of functional SA agonists in Arabidopsis thaliana that revealed Neratinib (Ner), a...

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Veröffentlicht in:	ACS chemical biology 2023-05, Vol.18 (5), p.1076-1088
Hauptverfasser:	Ninck, Sabrina, Halder, Vivek, Krahn, Jan H., Beisser, Daniela, Resch, Sarah, Dodds, Isobel, Scholtysik, René, Bormann, Jenny, Sewald, Leonard, Gupta, Mainak D., Heilmann, Geronimo, Bhandari, Deepak D., Morimoto, Kyoko, Buscaill, Pierre, Hause, Bettina, van der Hoorn, Renier A. L., Kaschani, Farnusch, Kaiser, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Arabidopsis - metabolism Arabidopsis Proteins - metabolism Epoxide Hydrolases - metabolism Gene Expression Regulation, Plant Humans Plant Growth Regulators - metabolism Salicylic Acid - metabolism
Online-Zugang:	Volltext
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