The myo-inositol biosynthesis rate-limiting enzyme ISYNA1 suppresses the stemness of ovarian cancer via Notch1 pathway

Cancer stem cells (CSCs) play a central role in ovarian cancer (OC), understanding regulatory mechanisms governing their stemness is critical. Here, we report ISYNA1, the rate-limiting enzyme in myo-inositol biosynthesis, as a suppressor of OC regulating cancer stemness. We identified ISYNA1 as a di...

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Veröffentlicht in:	Cellular signalling 2023-07, Vol.107, p.110688-110688, Article 110688
Hauptverfasser:	Yang, Lingling, Yang, Muyao, Cui, Chenxi, Long, Xingtao, Li, Yunzhe, Dai, Weili, Lang, Tingyuan, Zhou, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer stemness Cell Line, Tumor Cell Proliferation - genetics Female Humans Inositol - metabolism ISYNA1 Myo-inositol Neoplastic Stem Cells - metabolism Notch1 Ovarian cancer Ovarian Neoplasms - pathology Receptor, Notch1 - metabolism Signal Transduction
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