An extension to a 2-in-1 adaptive design with biomarker subpopulation selection

In a recent article, Jin and Zhang (2022) proposed an adaptive 2-in-1 design which can expand an ongoing Phase 2 trial with multiple treatment or dose arms into a confirmatory Phase 3 trial with the selected arms based on interim data, and proved that the design can preserve the familywise Type I er...

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Veröffentlicht in:	Contemporary clinical trials 2023-06, Vol.129, p.107209-107209, Article 107209
Hauptverfasser:	Jin, Man, Zhang, Pingye
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive 2-in-1 design Biomarker subpopulation Drug Development Humans Research Design Seamless Treatment or dose selection
Online-Zugang:	Volltext
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