Reconfigurable microfluidics
Lab-on-a-chip devices leverage microfluidic technologies to enable chemical and biological processes at small scales. However, existing microfluidic channel networks are typically designed for the implementation of a single function or a well-defined protocol and do not allow the flexibility and rea...
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| Veröffentlicht in: | Nature reviews. Chemistry 2022-01, Vol.6 (1), p.70-80 |
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| container_title | Nature reviews. Chemistry |
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| creator | Paratore, Federico Bacheva, Vesna Bercovici, Moran Kaigala, Govind V. |
| description | Lab-on-a-chip devices leverage microfluidic technologies to enable chemical and biological processes at small scales. However, existing microfluidic channel networks are typically designed for the implementation of a single function or a well-defined protocol and do not allow the flexibility and real-time experimental decision-making essential to many scientific applications. In this Perspective, we highlight that reconfigurability and programmability of microfluidic platforms can support new functionalities that are beyond the reach of current lab-on-a-chip systems. We describe the ideal fully reconfigurable microfluidic device that can change its shape and function dynamically, which would allow researchers to tune a microscale experiment with the capacity to make real-time decisions. We review existing technologies that can dynamically control microscale flows, suggest additional physical mechanisms that could be leveraged towards the goal of reconfigurable microfluidics and highlight the importance of these efforts for the broad scientific community.
In this Perspective, a vision of a fully reconfigurable microfluidic device that can change its shape and function dynamically is outlined. Reconfigurable microfluidic platforms can enable new functionalities, which have the potential to go beyond the reach of current lab-on-a-chip systems. |
| doi_str_mv | 10.1038/s41570-021-00343-9 |
| format | Article |
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| subjects | 639/166/898 639/638/11 639/638/898 639/766/930 Analytical Chemistry Biochemistry Biological activity Chemistry Chemistry and Materials Science Chemistry/Food Science Decision making Inorganic Chemistry Lab-on-a-chip Microfluidics Organic Chemistry Perspective Physical Chemistry Platforms Real time Reconfiguration |
| title | Reconfigurable microfluidics |
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