Forged in iron
Fifty years ago, Kochi reported the iron-catalysed cross-coupling of alkenyl halides and alkyl Grignard reagents. Sparking a cross-coupling revolution, we reflect on the impact of this achievement and the importance of iron in the development of cross-coupling catalysis. In a reaction discovered 50...
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| Veröffentlicht in: | Nature reviews. Chemistry 2021-04, Vol.5 (4), p.223-224 |
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| container_title | Nature reviews. Chemistry |
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| creator | Neate, Peter G. N. Neidig, Michael L. |
| description | Fifty years ago, Kochi reported the iron-catalysed cross-coupling of alkenyl halides and alkyl Grignard reagents. Sparking a cross-coupling revolution, we reflect on the impact of this achievement and the importance of iron in the development of cross-coupling catalysis.
In a reaction discovered 50 years ago, a disarmingly simple iron catalyst was shown to couple alkenyl halides to alkyl Grignard reagents. This finding led to a proliferation of catalytic methodologies that today are an indispensable part of our synthetic toolkit. |
| doi_str_mv | 10.1038/s41570-021-00259-4 |
| format | Article |
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| ispartof | Nature reviews. Chemistry, 2021-04, Vol.5 (4), p.223-224 |
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| language | eng |
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| subjects | 639/638 639/638/77 Analytical Chemistry Biochemistry Carbon Catalysis Chemistry Chemistry and Materials Science Chemistry/Food Science Cross coupling Halides Inorganic Chemistry Iron Ligands News & Views news-and-views Organic Chemistry Physical Chemistry Reagents |
| title | Forged in iron |
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