Synthesis, characterization and potential applications for oxidized agarose
The knowledge of agarose (AG) oxidation using periodate as oxidizer has not been systematically explored. This paper synthesized oxidized agarose (OAG) using solid-sate and solution reaction methods; the reaction mechanism and the properties of OAG samples were systematically evaluated. Chemical str...
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Veröffentlicht in: | International journal of biological macromolecules 2023-07, Vol.242 (Pt 1), p.124643-124643, Article 124643 |
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creator | Li, Chengpeng Li, Xianzhu Gu, Qixiang Xie, Lici Cai, Ying Liao, Lusheng |
description | The knowledge of agarose (AG) oxidation using periodate as oxidizer has not been systematically explored. This paper synthesized oxidized agarose (OAG) using solid-sate and solution reaction methods; the reaction mechanism and the properties of OAG samples were systematically evaluated. Chemical structure analysis disclosed that the aldehyde group and carboxyl group contents in all OAG samples are extremely low. Meanwhile, crystallinity, dynamic viscosity and molecular weight of OAG samples is lower than that of the original AG. Reaction temperature, time and sodium periodate dosage are inversely proportional to the decline of the gelling temperature (Tg) and melting temperature (Tm); and the Tg and Tm for the OAG sample obtained are even 19 °C and 22 °C lower than that of the original AG. The as-synthesized OAG samples all possess excellent cytocompatibility and blood compatibility; and can promote the proliferation and migration of fibroblast cells. Last but not least, the gel strength, hardness, cohesiveness, springiness and chewiness of the OAG gel can be effectively regulated via oxidation reaction. In conclusions, both solid and solution oxidation can regulate the physical properties of OAG and enlarge its potential applications in wound dressing, tissue engineering and food areas.
Properties for oxidized agarose. [Display omitted]
•Oxidation at high temperature leads to low aldehyde content for OAG.•Both solid and solution oxidation can decrease the crystallinity of oxidized agarose (OAG).•Both solid and solution oxidation can decrease the molecular weight of OAG. |
doi_str_mv | 10.1016/j.ijbiomac.2023.124643 |
format | Article |
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Properties for oxidized agarose. [Display omitted]
•Oxidation at high temperature leads to low aldehyde content for OAG.•Both solid and solution oxidation can decrease the crystallinity of oxidized agarose (OAG).•Both solid and solution oxidation can decrease the molecular weight of OAG.</description><identifier>ISSN: 0141-8130</identifier><identifier>EISSN: 1879-0003</identifier><identifier>DOI: 10.1016/j.ijbiomac.2023.124643</identifier><identifier>PMID: 37119904</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Agarose ; Cytocompatibility ; Gelling temperature ; Gels - chemistry ; Oxidation-Reduction ; Sepharose - chemistry ; Temperature ; Viscosity</subject><ispartof>International journal of biological macromolecules, 2023-07, Vol.242 (Pt 1), p.124643-124643, Article 124643</ispartof><rights>2023 Elsevier B.V.</rights><rights>Copyright © 2023 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c315t-42adc9c99c4ed61f2ddd03fad5dfb562bcc6e5b013e25c9cfef504923918319b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijbiomac.2023.124643$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37119904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Chengpeng</creatorcontrib><creatorcontrib>Li, Xianzhu</creatorcontrib><creatorcontrib>Gu, Qixiang</creatorcontrib><creatorcontrib>Xie, Lici</creatorcontrib><creatorcontrib>Cai, Ying</creatorcontrib><creatorcontrib>Liao, Lusheng</creatorcontrib><title>Synthesis, characterization and potential applications for oxidized agarose</title><title>International journal of biological macromolecules</title><addtitle>Int J Biol Macromol</addtitle><description>The knowledge of agarose (AG) oxidation using periodate as oxidizer has not been systematically explored. This paper synthesized oxidized agarose (OAG) using solid-sate and solution reaction methods; the reaction mechanism and the properties of OAG samples were systematically evaluated. Chemical structure analysis disclosed that the aldehyde group and carboxyl group contents in all OAG samples are extremely low. Meanwhile, crystallinity, dynamic viscosity and molecular weight of OAG samples is lower than that of the original AG. Reaction temperature, time and sodium periodate dosage are inversely proportional to the decline of the gelling temperature (Tg) and melting temperature (Tm); and the Tg and Tm for the OAG sample obtained are even 19 °C and 22 °C lower than that of the original AG. The as-synthesized OAG samples all possess excellent cytocompatibility and blood compatibility; and can promote the proliferation and migration of fibroblast cells. Last but not least, the gel strength, hardness, cohesiveness, springiness and chewiness of the OAG gel can be effectively regulated via oxidation reaction. In conclusions, both solid and solution oxidation can regulate the physical properties of OAG and enlarge its potential applications in wound dressing, tissue engineering and food areas.
Properties for oxidized agarose. [Display omitted]
•Oxidation at high temperature leads to low aldehyde content for OAG.•Both solid and solution oxidation can decrease the crystallinity of oxidized agarose (OAG).•Both solid and solution oxidation can decrease the molecular weight of OAG.</description><subject>Agarose</subject><subject>Cytocompatibility</subject><subject>Gelling temperature</subject><subject>Gels - chemistry</subject><subject>Oxidation-Reduction</subject><subject>Sepharose - chemistry</subject><subject>Temperature</subject><subject>Viscosity</subject><issn>0141-8130</issn><issn>1879-0003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAQgC0EoqXwF6qMDCT47CSNN1DFS1RiAGbLsS_UVRoHO0W0v56UtqxMJ9199_oIGQNNgEJ-vUjsorRuqXTCKOMJsDRP-REZQjERMaWUH5MhhRTiAjgdkLMQFn02z6A4JQM-ARCCpkPy_LpuujkGG64iPVde6Q693ajOuiZSjYla12HTWVVHqm1rq38rIaqcj9y3NXaDJlIfyruA5-SkUnXAi30ckff7u7fpYzx7eXia3s5izSHr4pQpo4UWQqdocqiYMYbySpnMVGWWs1LrHLOSAkeW9WCFVUZTwbiAgoMo-Yhc7ua23n2uMHRyaYPGulYNulWQrKATQQXQvEfzHar7A4PHSrbeLpVfS6ByK1Iu5EGk3IqUO5F943i_Y1Uu0fy1Hcz1wM0OwP7TL4teBm2x0WisR91J4-x_O34Ayb-JIg</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Li, Chengpeng</creator><creator>Li, Xianzhu</creator><creator>Gu, Qixiang</creator><creator>Xie, Lici</creator><creator>Cai, Ying</creator><creator>Liao, Lusheng</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230701</creationdate><title>Synthesis, characterization and potential applications for oxidized agarose</title><author>Li, Chengpeng ; Li, Xianzhu ; Gu, Qixiang ; Xie, Lici ; Cai, Ying ; Liao, Lusheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c315t-42adc9c99c4ed61f2ddd03fad5dfb562bcc6e5b013e25c9cfef504923918319b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Agarose</topic><topic>Cytocompatibility</topic><topic>Gelling temperature</topic><topic>Gels - chemistry</topic><topic>Oxidation-Reduction</topic><topic>Sepharose - chemistry</topic><topic>Temperature</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Chengpeng</creatorcontrib><creatorcontrib>Li, Xianzhu</creatorcontrib><creatorcontrib>Gu, Qixiang</creatorcontrib><creatorcontrib>Xie, Lici</creatorcontrib><creatorcontrib>Cai, Ying</creatorcontrib><creatorcontrib>Liao, Lusheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of biological macromolecules</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Chengpeng</au><au>Li, Xianzhu</au><au>Gu, Qixiang</au><au>Xie, Lici</au><au>Cai, Ying</au><au>Liao, Lusheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, characterization and potential applications for oxidized agarose</atitle><jtitle>International journal of biological macromolecules</jtitle><addtitle>Int J Biol Macromol</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>242</volume><issue>Pt 1</issue><spage>124643</spage><epage>124643</epage><pages>124643-124643</pages><artnum>124643</artnum><issn>0141-8130</issn><eissn>1879-0003</eissn><abstract>The knowledge of agarose (AG) oxidation using periodate as oxidizer has not been systematically explored. This paper synthesized oxidized agarose (OAG) using solid-sate and solution reaction methods; the reaction mechanism and the properties of OAG samples were systematically evaluated. Chemical structure analysis disclosed that the aldehyde group and carboxyl group contents in all OAG samples are extremely low. Meanwhile, crystallinity, dynamic viscosity and molecular weight of OAG samples is lower than that of the original AG. Reaction temperature, time and sodium periodate dosage are inversely proportional to the decline of the gelling temperature (Tg) and melting temperature (Tm); and the Tg and Tm for the OAG sample obtained are even 19 °C and 22 °C lower than that of the original AG. The as-synthesized OAG samples all possess excellent cytocompatibility and blood compatibility; and can promote the proliferation and migration of fibroblast cells. Last but not least, the gel strength, hardness, cohesiveness, springiness and chewiness of the OAG gel can be effectively regulated via oxidation reaction. In conclusions, both solid and solution oxidation can regulate the physical properties of OAG and enlarge its potential applications in wound dressing, tissue engineering and food areas.
Properties for oxidized agarose. [Display omitted]
•Oxidation at high temperature leads to low aldehyde content for OAG.•Both solid and solution oxidation can decrease the crystallinity of oxidized agarose (OAG).•Both solid and solution oxidation can decrease the molecular weight of OAG.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37119904</pmid><doi>10.1016/j.ijbiomac.2023.124643</doi><tpages>1</tpages></addata></record> |
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subjects | Agarose Cytocompatibility Gelling temperature Gels - chemistry Oxidation-Reduction Sepharose - chemistry Temperature Viscosity |
title | Synthesis, characterization and potential applications for oxidized agarose |
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