Cytoplasmic localization of Mdm2 in cells expressing mutated NPM is mediated by p53

Specific C-terminal nucleophosmin (NPM) mutations are related to the acute myeloid leukaemia and cause mistargeting of mutated NPM (NPMmut) to the cytoplasm. Consequently, multiple NPM-interacting partners, e.g., the tumour suppressor p53, become also mislocalized. We found that ubiquitin ligase Mdm...

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Veröffentlicht in:	The FEBS journal 2023-09, Vol.290 (17), p.4281-4299
Hauptverfasser:	Strachotová, Dita, Holoubek, Aleš, Wolfová, Kateřina, Brodská, Barbora, Heřman, Petr
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Acute myeloid leukemia Cytoplasm Fluorescence Immunoprecipitation Leukemia Localization Lysates MDM2 protein p53 Protein Tumor suppressor genes Ubiquitin Ubiquitin-protein ligase
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